Results 71 to 80 of about 7,104 (202)

Evolutionary conservation of intrinsically unstructured regions in slit-diaphragm proteins.

PLoS ONE, 2021
Vertebrate kidneys contribute to homeostasis by regulating electrolyte, acid-base balance, removing toxic metabolites from blood, and preventing protein loss into the urine.
Sandeep K N Mulukala, Vaishnavi Kambhampati, Abrar H Qadri, Anil K Pasupulati   +3 more
doaj   +1 more source

Maternal Ethanol Exposure Impairs the Kidney of Offspring by Alteration of Podocyte Proteins Genes Expression and Fibrosis

Journal of Kerman University of Medical Sciences, 2022
Background: This study examined the effect of prenatal and early postnatal ethanol exposure on the structural, functional, and molecular alterations of rat’s offspring kidney on postnatal days 21 and 90.
Farideh Nezami Majd, Alireza Shirpoor, Ali Taghizadeh Afshari , Fatemeh Kheradmand , Roya Naderi , Masoumeh Pourjabali, Yousef Rasmi   +6 more
doaj   +1 more source

Identification and characterization of novel glomerulus-associated genes and proteins [PDF]

, 2010
The kidney is responsible for sieving the circulating blood to eliminate water-soluble waste products and potentially toxic substances from the body. The filtration step occurs in specialized filtration units called glomeruli.
Xiao, Zhijie
core  

Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure [PDF]

, 2016
Pharmacological blockade of the N-and L-type calcium channel lessens renal injury in kidney disease patients. The significance of specific blockade of α1 subunit of N-type calcium channel, Cav2.2, in diabetic nephropathy, however, remains to be clarified.
Fujikura, Junji, Imamaki, Hirotaka, Ishii, Akira, Kasahara, Masato, Kuwabara, Takashige, Kuwahara, Koichiro, Mori, Kiyoshi, Mori, Yasuo, Mukoyama, Masashi, Naito, Masaki, Nakao, Kazuwa, Numata, Tomohiro, Ohno, Shoko, Saleem, Moin, Yanagita, Motoko, Yokoi, Hideki   +15 more
core   +4 more sources

Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes

Journal of Cellular Physiology, Volume 241, Issue 1, January 2026.
Abstract Preservation of the insulin‐sensitive glomerular podocyte is imperative for normal kidney function. The protein tyrosine phosphatases (PTPs), protein tyrosine phosphatase 1B (PTP1B), T‐cell protein tyrosine phosphatase (TCPTP), and Src homology phosphatase 2 (SHP2) are established regulators of insulin signaling in vivo and implicated in renal
Grace LeBleu, Ming‐Fo Hsu, Yoshihiro Ito, Suh‐Yuen Liang, Kwan‐Liu Ma, Tzu‐Ching Meng, Fawaz G. Haj   +6 more
wiley   +1 more source

A zebrafish model of conditional targeted podocyte ablation and regeneration [PDF]

, 2014
Podocytes are specialized cells that contribute critically to the normal structure and function of the glomerular filtration barrier. Their depletion plays an important role in the pathogenesis of glomerulosclerosis.
Davidson, Alan J, Huang, Hong Dong, Huang, Jianmin, Lu, Hua A J, Mckee, Mary, Xiang, Alice   +5 more
core   +1 more source

Induction of Nephron–Ductal Dual Lineages via Early Retinoic Acid Signaling Establishes a Platform for Fully Patterned Kidney Organoids

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
A simplified, co‐culture‐free protocol for kidney organoids that generate segmented nephrons, including collecting ducts, has been developed. Early low‐dose RA with FGF9 induces balanced anterior–posterior IM patterning and dual UE/MM lineage commitment. BMP7 enhances nephron progenitor maturation.
Jung Hwa Lim, Seeun Kim, Dong Hyun Lee, Dae Hun Kim, Hye Bin Lee, Ye Seul Son, Mi‐Young Son, Soo Jin Oh, Ji‐Yoon Lee, Mi‐Ok Lee, Hyun Soo Cho, Dae‐Soo Kim, Cho‐Rok Jung, Hyun Mi Kang   +13 more
wiley   +1 more source

Rapamycin Ameliorates Proteinuria and Restores Nephrin and Podocin Expression in Experimental Membranous Nephropathy [PDF]

Clinical and Developmental Immunology, 2013
Objective. Recent studies have shown a beneficial effect of rapamycin in passive and active Heymann Nephritis (HN). However, the mechanisms underlying this beneficial effect have not been elucidated.Methods. Passive Heymann Nephritis (PHN) was induced by a single intravenous infusion of anti-Fx1 in 12 Sprague-Dawley male rats.
Stratakis, S., Stylianou, K., Petrakis, I., Mavroeidi, V., Poulidaki, R., Petra, C., Moisiadis, D., Stratigis, S., Vardaki, E., Nakopoulou, L., Daphnis, E.   +10 more
openaire   +4 more sources

Resistance to doxorubicin‐induced proteinuria and proteolytic activation of ENaC in 129S2/SvPas mice

Physiological Reports, Volume 13, Issue 23, December 2025.
Abstract Doxorubicin treatment of mice represents a convenient model to study the effects of proteinuria on proteolytic processing of the epithelial Na+ channel (ENaC) and urinary Na+ and fluid handling. Prior studies have shown enhanced ENaC γ subunit proteolysis and Na+ and fluid retention in 129S1/SvImJ mice treated with doxorubicin.
Evan C. Ray, Ivy Liu, Niloofar Momenzadeh, Kennedy Szekely, Allison L. Marciszyn, Tracey Lam, Andrew J. Nickerson, Thomas R. Kleyman   +7 more
wiley   +1 more source

槲皮素对糖尿病大鼠肾脏足细胞nephrin和podocin表达的影响

Zhongguo shiyan zhenduanxue, 2019
目的探讨槲皮素对糖尿病大鼠肾脏足细胞nephrin和podocin表达的影响。方法采用腹腔注射链脲佐菌素(STZ)方法构建糖尿病大鼠模型,分为正常对照组、糖尿病模型组、槲皮素给药组。12周后测定肾脏指数、血肌酐、尿素水平及24h尿中总蛋白、白蛋白、肌酐、尿素水平;Western blot方法检测肾皮质nephrin和podocin的蛋白表达。结果槲皮素给药组肾脏指数、血肌酐和尿素水平低于糖尿病模型组;槲皮素给药组尿中总蛋白、白蛋白水平明显低于糖尿病组,尿中肌酐、尿素水平高于糖尿病组 ...
靳英丽, 屈智慧, 杨盼盼, 袁渤雨, 陈丽波   +4 more
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