Results 71 to 80 of about 7,139 (201)
Advanced Science, Volume 13, Issue 9, 13 February 2026.SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li +14 more
wiley +1 more source
Evolutionary conservation of intrinsically unstructured regions in slit-diaphragm proteins.
PLoS ONE, 2021 Vertebrate kidneys contribute to homeostasis by regulating electrolyte, acid-base balance, removing toxic metabolites from blood, and preventing protein loss into the urine.
Sandeep K N Mulukala +3 more
doaj +1 more source
Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach
Frontiers in Medicine, 2018 Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms associated with significant losses of protein in the urine.
Samuel Mon-Wei Yu +4 more
doaj +1 more source
Identification and characterization of novel glomerulus-associated genes and proteins [PDF]
, 2010 The kidney is responsible for sieving the circulating blood to eliminate water-soluble waste products and potentially toxic substances from the body. The filtration step occurs in specialized filtration units called glomeruli.
Xiao, Zhijie
core
Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling [PDF]
, 2003 Mutations of NPHS1 or NPHS2, the genes encoding nephrin and podocin, as well as the targeted disruption of CD2-associated protein (CD2AP), lead to heavy proteinuria, suggesting that all three proteins are essential for the integrity of glomerular ...
Benzing, Thomas +12 more
core +3 more sources
Journal of Cellular Physiology, Volume 241, Issue 1, January 2026.Abstract Preservation of the insulin‐sensitive glomerular podocyte is imperative for normal kidney function. The protein tyrosine phosphatases (PTPs), protein tyrosine phosphatase 1B (PTP1B), T‐cell protein tyrosine phosphatase (TCPTP), and Src homology phosphatase 2 (SHP2) are established regulators of insulin signaling in vivo and implicated in renal
Grace LeBleu +6 more
wiley +1 more source
Clinical and epidemiological assessment of steroid-resistant nephrotic syndrome associated with the NPHS2 R229Q variant [PDF]
, 2009 Mutations of NPHS2, encoding podocin, are the main cause of autosomal recessive steroid-resistant nephrotic syndrome (NS) presenting in childhood.
Machuca, Eduardo +9 more
core +1 more source
PLoS ONE, 2019 There are controversies whether Minimal Change Disease (MCD) and Focal and Segmental Glomerulosclerosis (FSGS) are distinct glomerular lesions or different manifestations within the same spectrum of diseases.
Lívia Helena de Morais Pereira +10 more
doaj +1 more source
Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.A simplified, co‐culture‐free protocol for kidney organoids that generate segmented nephrons, including collecting ducts, has been developed. Early low‐dose RA with FGF9 induces balanced anterior–posterior IM patterning and dual UE/MM lineage commitment. BMP7 enhances nephron progenitor maturation.
Jung Hwa Lim +13 more
wiley +1 more source
Resistance to doxorubicin‐induced proteinuria and proteolytic activation of ENaC in 129S2/SvPas mice
Physiological Reports, Volume 13, Issue 23, December 2025.Abstract Doxorubicin treatment of mice represents a convenient model to study the effects of proteinuria on proteolytic processing of the epithelial Na+ channel (ENaC) and urinary Na+ and fluid handling. Prior studies have shown enhanced ENaC γ subunit proteolysis and Na+ and fluid retention in 129S1/SvImJ mice treated with doxorubicin.
Evan C. Ray +7 more
wiley +1 more source