Results 91 to 100 of about 15,233 (264)

It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]

, 2016
The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core   +2 more sources

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation. [PDF]

, 2019
Nicotinamide adenine dinucleotide (NAD+)-dependent ADP-ribosylation plays important roles in physiology and pathophysiology. It has been challenging to study this key type of enzymatic post-translational modification in particular for protein poly-ADP ...
Chen, Jingwen, Cheng, Qinqin, Dai, Zhefu, Evdokimov, Nikolai M, Lam, Albert T, Louie, Stan G, Lu, Yanran, Pei, Hua, Zhang, Xiao-Nan, Zhang, Yong   +9 more
core   +1 more source

Drugging the Cancers Addicted to DNA Repair [PDF]

, 2017
Defects in DNA repair can result in oncogenic genomic instability. Cancers occurring from DNA repair defects were once thought to be limited to rare inherited mutations (such as BRCA1 or 2).
Hromas, Robert, Jones, Dennie, Lee, Suk-Hee, Nickoloff, Jac A., Williamson, Elizabeth A.   +4 more
core   +1 more source

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

The Ser/Thr protein kinase FonKin4-poly(ADP-ribose) polymerase FonPARP1 phosphorylation cascade is required for the pathogenicity of watermelon fusarium wilt fungus Fusarium oxysporum f. sp. niveum

Frontiers in Microbiology
Poly(ADP-ribosyl)ation (PARylation), catalyzed by poly(ADP-ribose) polymerases (PARPs) and hydrolyzed by poly(ADP-ribose) glycohydrolase (PARG), is a kind of post-translational protein modification that is involved in various cellular processes in fungi,
Jiajing Wang, Jiajing Wang, Yizhou Gao, Yizhou Gao, Xiaohui Xiong, Xiaohui Xiong, Yuqing Yan, Yuqing Yan, Jiajun Lou, Jiajun Lou, Muhammad Noman, Dayong Li, Dayong Li, Fengming Song, Fengming Song, Fengming Song   +15 more
doaj   +1 more source

Functions of PARylation in DNA Damage Repair Pathways

Genomics, Proteomics & Bioinformatics, 2016
Protein poly ADP-ribosylation (PARylation) is a widespread post-translational modification at DNA lesions, which is catalyzed by poly(ADP-ribose) polymerases (PARPs).
Huiting Wei, Xiaochun Yu
doaj   +1 more source

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis [PDF]

, 2018
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease. Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly leading to death within ~ 2–5 years of symptomatic onset. There is no cure, and
A Chiarugi, A Chiarugi, A Sonnenblick, AA Fatokun, AC Elden, AE Renton, AK Leung, B Luscher, B Nefussy, BA Gibson, C Benkler, C Cosi, C Culmsee, C Hewitt, C Vance, CR Calabrese, D Petrov, DR Rosen, DR Thal, E Bentmann, E Kiskinis, E Turunc Bayrakdar, EM Park, EV Hobson, F Geser, F Moroni, G Kim, GE Abdelkarim, GM Shah, Group AS, Group AS, H Braak, H Braak, H Farmer, H Kawamitsu, H Sawada, H Yokoyama, HE Bryant, HJ Kim, HT Chung, IG McKeith, IR Mackenzie, J Brettschneider, J Mojsilovic-Petrovic, J Mojsilovic-Petrovic, J Rosenfeld, J Sreedharan, J Zhang, JC Morris, JD Rothstein, JD Rothstein, JD Rothstein, JP Taylor, JS Bae, K Takahashi, K Uryu, K Zhang, KW Caldecott, L Lehtio, L Liu-Yesucevitz, L Mariotti, L McGurk, L Van Den Bosch, LA Becker, LP Rowland, M Altmeyer, M Citarelli, M DeJesus-Hernandez, M Endres, M Endres, M Hasegawa, M Isabelle, M Naumann, M Neumann, M Neumann, M Neumann, MA Farg, MJ Finelli, MO Hottiger, NA Berger, NL Kedersha, O Hardiman, O Spreux-Varoquaux, OA Andreassen, P Anderson, PJ Shaw, PL Oliver, R Gupte, R Krishnakumar, RH Tan, S Hanai, S Martire, S Martire, S Saxena, SA Andrabi, SB Gibson, SC Ling, SH Kaufmann, SH Kim, SH Kim, SH Koh, SL Rulten, SS Mirra, T Haikarainen, TJ Kwiatkowski Jr, TM Kauppinen, V Schreiber, VL Dawson, X Luo, Y Wang, YH Chung, YR Li, ZY Abd Elmageed   +112 more
core   +2 more sources

Targeting dePARylation for cancer therapy

Cell & Bioscience, 2020
Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects ...
Muzaffer Ahmad Kassab, Lily L. Yu, Xiaochun Yu   +2 more
doaj   +1 more source

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy [PDF]

, 2013
Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents.
Alagoz, Boyd, Breslin, Caldecott, Chen, Chiang, Ciccia, Dalhus, Das, Demple, Dungey, El-Khamisy, Fu, Godon, Hecht, Hegde, Hudson, Interthal, Interthal, Kato, Katyal, Kummar, Lebedeva, Lindahl, Lindahl, Liu, Loeb, Luo, Madhusudan, Meisenberg, Meryem Alagoz, Mohammed, Morland, Murai, Murai, Nilsen, Owen S. Wells, Pommier, Pourquier, Povirk, Ray Chaudhuri, Rydberg, Sherif F. El-Khamisy, Strom, Sultana, Takashima, Wilson, Xanthoudakis, Yang, Zeng, Zhou   +50 more
core   +1 more source