Results 21 to 30 of about 39,389 (304)

Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. [PDF]

Cell Metab, 2014
Pirinen E, Cantó C, Jo YS, Morato L, Zhang H, Menzies KJ, Williams EG, Mouchiroud L, Moullan N, Hagberg C, Li W, Timmers S, Imhof R, Verbeek J, Pujol A, van Loon B, Viscomi C, Zeviani M, Schrauwen P, Sauve AA, Schoonjans K, Auwerx J.   +21 more
europepmc   +2 more sources

Correction for Brady et al., "Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity". [PDF]

Microbiol Mol Biol Rev, 2019
Brady PN, Goel A, Johnson MA.
europepmc   +3 more sources

Characterization of an Aedes ADP-Ribosylation Protein Domain and Role of Post-Translational Modification during Chikungunya Virus Infection

Pathogens, 2023
Poly ADP-ribose polymerases (PARPs) catalyze ADP-ribosylation, a subclass of post-translational modification (PTM). Mono-ADP-ribose (MAR) moieties bind to target molecules such as proteins and nucleic acids, and are added as part of the process which ...
Ramesh Kumar, Divya Mehta, Debasis Nayak, Sujatha Sunil   +3 more
doaj   +1 more source

Selective monitoring of the protein-free ADP-ribose released by ADP-ribosylation reversal enzymes.

PLoS ONE, 2021
ADP-ribosylation is a key post-translational modification that regulates a wide variety of cellular stress responses. The ADP-ribosylation cycle is maintained by writers and erasers.
Samuel Kasson, Nuwani Dharmapriya, In-Kwon Kim   +2 more
doaj   +1 more source

Poly(ADP-Ribose) Polymerase Inhibitors [PDF]

Journal of Thoracic Oncology, 2010
This session not only described several poly(ADP-ribose) polymerase (PARP) inhibitors but also included talks on the science of nuclear excision repair, an oxidized glutathione, and a heat shock protein (HSP) 90 inhibitor. SUMMARY OF PRESENTATIONS Science of Nuclear Excision Repair Dr.
Garon, Edward B., Dubinett, Steven M.
openaire   +2 more sources

Protein poly(ADP-ribosyl)ation regulates arabidopsis immune gene expression and defense responses. [PDF]

PLoS Genetics, 2015
Perception of microbe-associated molecular patterns (MAMPs) elicits transcriptional reprogramming in hosts and activates defense to pathogen attacks. The molecular mechanisms underlying plant pattern-triggered immunity remain elusive.
Baomin Feng, Chenglong Liu, Marcos V V de Oliveira, Aline C Intorne, Bo Li, Kevin Babilonia, Gonçalo A de Souza Filho, Libo Shan, Ping He   +8 more
doaj   +1 more source

Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones

Nature Communications, 2022
Poly(ADP-ribose)-polymerases (PARPs) are a cornerstone of the DNA damage response that promote DNA repair by modifying target proteins with ADP-ribose.
Julien Brustel, Tetsuya Muramoto, Kazuki Fumimoto, Jessica Ellins, Catherine J. Pears, Nicholas D. Lakin   +5 more
doaj   +1 more source

Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

Nature Reviews Drug Discovery, 2005
P. Jagtap, C. Szabó
exaly   +2 more sources

Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase. [PDF]

PLoS ONE, 2009
The formation of ADP-ribose polymers on target proteins by poly(ADP-ribose) polymerases serves a variety of cell signaling functions. In addition, extensive activation of poly(ADP-ribose) polymerase-1 (PARP-1) is a dominant cause of cell death in ...
David M Burns, Weihai Ying, Tiina M Kauppinen, Keqing Zhu, Raymond A Swanson   +4 more
doaj   +1 more source

The Critical Role of PARPs in Regulating Innate Immune Responses

Frontiers in Immunology, 2021
Poly (adenosine diphosphate-ribose) polymerases (PARPs) are a family of proteins responsible for transferring ADP-ribose groups to target proteins to initiate the ADP-ribosylation, a highly conserved and fundamental post-translational modification in all
Huifang Zhu, Yan-Dong Tang, Guoqing Zhan, Chenhe Su, Chunfu Zheng   +4 more
doaj   +1 more source