Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer [PDF]
Cells, 2023 Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Amanda Qi +5 more
doaj +2 more sources
The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax [PDF]
Haematologica, 2017 Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia ...
Ana M. Cosialls +12 more
doaj +3 more sources
Targeting Prohibitins to Inhibit Melanoma Growth and Overcome Resistance to Targeted Therapies [PDF]
Cells, 2023 Despite important advances in the treatment of metastatic melanoma with the development of MAPK-targeted agents and immune checkpoint inhibitors, the majority of patients either do not respond to therapies or develop acquired resistance.
Ahmad Najem +7 more
doaj +2 more sources
Prohibitions in the meta-inflammatory response: a review [PDF]
Frontiers in Molecular BiosciencesProhibitins are the central regulatory element of cellular homeostasis, especially by modulating the response at different levels: Nucleus, mitochondria and membranes.
Natalia Todosenko +5 more
doaj +2 more sources
Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance [PDF]
Microbiology SpectrumThe SPFH (stomatin, prohibitin, flotillin, and HflK/HflC) protein superfamily is conserved across all domains of life. Fungal SPFH proteins are required for respiration, stress adaptation, and membrane scaffolding. In the yeast Candida albicans, stomatin-
Hyunjeong Kim +7 more
doaj +2 more sources
Comparative effects of antimalarial drugs on oxidative phosphorylation, mitochondrial dynamics and mitophagy in Plasmodium berghei-infected mice [PDF]
Toxicology ReportsMitochondria occupy prominent position in cell metabolism. Information on changes in host mitochondrial capacity in electron transport system, dynamics and mitophagy in mice infected with resistant Plasmodium berghei and thereafter treated with some ...
John Oludele Olanlokun +5 more
doaj +2 more sources
Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids [PDF]
Frontiers in Immunology, 2023 Background and aimsIgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder.
Remco Kersten +6 more
doaj +2 more sources
Mitochondrial damage and IL-1β production in monocytes caused by Neospora caninum infection are mediated by dense granule protein 7 and prohibitins [PDF]
Frontiers in ImmunologyIntroductionThe intracellular proliferation of Neospora caninum tachyzoites and the host immune response against infection are key steps in the pathogenesis of neosporosis. However, the molecules responsible for the activation of the inflammasome induced
Yu Chen +10 more
doaj +2 more sources
The prohibitin ligand IN44 decreases Porphyromonas gingivalis mediated inflammation [PDF]
BMC Oral HealthBackground Periodontitis is an inflammatory disease causing destruction of periodontal tissues. Controlling inflammation is crucial for periodontitis treatment. Prohibitins (PHBs) are emerging targets in the treatment of inflammatory diseases.
Céline Stutz +8 more
doaj +2 more sources
The SPFH complex HflK-HflC regulates aerobic respiration in bacteria. [PDF]
PLoS BiologyThe bacterial HflK-HflC membrane complex is a member of the highly conserved family of SPFH proteins, which are present in all domains of life and include eukaryotic stomatins, flotillins, and prohibitins.
María Isabel Pérez-López +7 more
doaj +2 more sources