Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer [PDF]
Cells, 2023 Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Amanda Qi +5 more
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The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax [PDF]
Haematologica, 2017 Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia ...
Ana M. Cosialls +12 more
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Targeting Prohibitins to Inhibit Melanoma Growth and Overcome Resistance to Targeted Therapies [PDF]
Cells, 2023 Despite important advances in the treatment of metastatic melanoma with the development of MAPK-targeted agents and immune checkpoint inhibitors, the majority of patients either do not respond to therapies or develop acquired resistance.
Ahmad Najem +7 more
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Prohibitions in the meta-inflammatory response: a review [PDF]
Frontiers in Molecular BiosciencesProhibitins are the central regulatory element of cellular homeostasis, especially by modulating the response at different levels: Nucleus, mitochondria and membranes.
Natalia Todosenko +5 more
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Mitochondrial prohibitin complex regulates fungal virulence via ATG24-assisted mitophagy [PDF]
Communications Biology, 2022 Prohibitins recruit ChATG24 into the mitochondria to modulate mitophagy, thereby affecting the virulence of Colletotrichum higginsianum.
Yaqin Yan +9 more
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Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance [PDF]
Microbiology SpectrumThe SPFH (stomatin, prohibitin, flotillin, and HflK/HflC) protein superfamily is conserved across all domains of life. Fungal SPFH proteins are required for respiration, stress adaptation, and membrane scaffolding. In the yeast Candida albicans, stomatin-
Hyunjeong Kim +7 more
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Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids [PDF]
Frontiers in Immunology, 2023 Background and aimsIgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder.
Remco Kersten +6 more
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Comparative effects of antimalarial drugs on oxidative phosphorylation, mitochondrial dynamics and mitophagy in Plasmodium berghei-infected mice [PDF]
Toxicology ReportsMitochondria occupy prominent position in cell metabolism. Information on changes in host mitochondrial capacity in electron transport system, dynamics and mitophagy in mice infected with resistant Plasmodium berghei and thereafter treated with some ...
John Oludele Olanlokun +5 more
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Prohibitins are required for cancer cell proliferation and adhesion. [PDF]
PLoS ONE, 2010 Prohibitin 1 (PHB1) is a highly conserved protein that together with its homologue prohibitin 2 (PHB2) mainly localizes to the inner mitochondrial membrane.
Claudia Sievers +3 more
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The prohibitin ligand IN44 decreases Porphyromonas gingivalis mediated inflammation [PDF]
BMC Oral HealthBackground Periodontitis is an inflammatory disease causing destruction of periodontal tissues. Controlling inflammation is crucial for periodontitis treatment. Prohibitins (PHBs) are emerging targets in the treatment of inflammatory diseases.
Céline Stutz +8 more
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