Results 11 to 20 of about 2,442 (188)

Prohibitin and mitochondrial biology [PDF]

Trends in Endocrinology & Metabolism, 2009
8 pages, 2 figures.--PMID: 19733482 [PubMed]Prohibitins are ubiquitous, evolutionarily conserved proteins that are mainly localized in mitochondria. The mitochondrial prohibitin complex comprises two subunits, PHB1 and PHB2.
Artal-Sanz, Marta, Tavernarakis, Nektarios   +1 more
core   +6 more sources

Prohibitins in neurodegeneration and mitochondrial homeostasis

Frontiers in Aging, 2022
The incidence of age-related neurodegenerative disorders has risen with the increase of life expectancy. Unfortunately, the diagnosis of such disorders is in most cases only possible when the neurodegeneration status is already advanced, and symptoms are
Jesus Fernandez-Abascal, Jesus Fernandez-Abascal, Marta Artal-Sanz, Marta Artal-Sanz   +3 more
doaj   +5 more sources

OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase

Cell Reports
Summary: Mitochondrial proteins are transported and sorted to the matrix or inner mitochondrial membrane by the presequence translocase TIM23. In yeast, this essential and highly conserved machinery is composed of the core subunits Tim23 and Tim17.
Praveenraj Elancheliyan, Klaudia K. Maruszczak, Remigiusz Adam Serwa, Till Stephan, Ahmet Sadik Gulgec, Mayra A. Borrero-Landazabal, Sonia Ngati, Aleksandra Gosk, Stefan Jakobs, Michal Wasilewski, Agnieszka Chacinska   +10 more
doaj   +2 more sources

The mitochondrial complexome of Medicago truncatula [PDF]

Frontiers in Plant Science, 2013
Legumes (Fabaceae, Leguminosae) are unique in their ability to carry out an elaborate endosymbiotic nitrogen fixation process with rhizobia proteobacteria.
Leonard Muriithi Kiirika, Christof eBehrens, Hans-Peter eBraun, Frank eColditz   +3 more
doaj   +4 more sources

mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage [PDF]

Cell Communication and Signaling
Introduction Cardiac mitochondrial function is intricately regulated by various processes, ultimately impacting metabolic performance. Additionally, protein turnover is crucial for sustained metabolic homeostasis in cardiomyocytes.
Hugo E. Verdejo, Valentina Parra, Andrea del Campo, Cesar Vasquez-Trincado, Damian Gatica, Camila Lopez-Crisosto, Jovan Kuzmicic, Leslye Venegas-Zamora, Ursula Zuñiga-Cuevas, Mayarling F. Troncoso, Rodrigo Troncoso, Beverly A. Rothermel, Mario Chiong, E. Dale Abel, Sergio Lavandero   +14 more
doaj   +2 more sources

Functions of J-domain proteins in mitochondrial protein biogenesis. [PDF]

Protein Sci
Abstract Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...
Tiku V, Bossenz G, Kirstein J, Becker T.
europepmc   +2 more sources

Prohibitins [PDF]

Current Biology, 2017
Tatsuta and Langer introduce prohibitins, membrane scaffolding proteins found predominantly in mitochondria.
Tatsuta, T., Langer, T.
openaire   +3 more sources

In situ architecture of the human prohibitin complex. [PDF]

Nat Cell Biol
AbstractProhibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, apoptosis, lifespan regulation and many others1, 2.
Lange F, Ratz M, Dohrke JN, Le Vasseur M, Wenzel D, Ilgen P, Riedel D, Jakobs S.   +7 more
europepmc   +7 more sources

Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling

Antioxidants, 2023
Recent studies have shown that FMS-like receptor tyrosine kinase 3 (Flt3) has a beneficial effect on cardiac maladaptive remodeling. However, the role and mechanism of Flt3 in mitochondrial dynamic imbalance under cardiac stress remains poorly understood.
Kaina Zhang, Yeqing Zheng, Gaowa Bao, Wenzhuo Ma, Bing Han, Hongwen Shi, Zhenghang Zhao   +6 more
doaj   +1 more source

Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases

Frontiers in Genetics, 2021
A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins
Misa Belser, David W. Walker, David W. Walker   +2 more
doaj   +1 more source