Results 11 to 20 of about 2,450 (184)

Prohibitin and mitochondrial biology [PDF]

Trends in Endocrinology & Metabolism, 2009
8 pages, 2 figures.--PMID: 19733482 [PubMed]Prohibitins are ubiquitous, evolutionarily conserved proteins that are mainly localized in mitochondria. The mitochondrial prohibitin complex comprises two subunits, PHB1 and PHB2.
Artal-Sanz, Marta, Tavernarakis, Nektarios   +1 more
core   +6 more sources

Prohibitins in neurodegeneration and mitochondrial homeostasis

Frontiers in Aging, 2022
The incidence of age-related neurodegenerative disorders has risen with the increase of life expectancy. Unfortunately, the diagnosis of such disorders is in most cases only possible when the neurodegeneration status is already advanced, and symptoms are
Jesus Fernandez-Abascal, Jesus Fernandez-Abascal, Marta Artal-Sanz, Marta Artal-Sanz   +3 more
doaj   +5 more sources

Mitochondrial damage and IL-1β production in monocytes caused by Neospora caninum infection are mediated by dense granule protein 7 and prohibitins [PDF]

Frontiers in Immunology
IntroductionThe intracellular proliferation of Neospora caninum tachyzoites and the host immune response against infection are key steps in the pathogenesis of neosporosis. However, the molecules responsible for the activation of the inflammasome induced
Yu Chen, Naomi Shimoda, Coh-ichi Nihei, Ryuichi Sawa, Yuko Takahashi, Mitsuhiro Nishigori, Shu Nakamura, Jingwei Liu, Takumi Koshiba, Nanako Ushio-Watanabe, Yoshifumi Nishikawa   +10 more
doaj   +2 more sources

The SPFH complex HflK-HflC regulates aerobic respiration in bacteria. [PDF]

PLoS Biology
The bacterial HflK-HflC membrane complex is a member of the highly conserved family of SPFH proteins, which are present in all domains of life and include eukaryotic stomatins, flotillins, and prohibitins.
María Isabel Pérez-López, Paul Lubrano, Georgia Angelidou, Sarah Hoch, Timo Glatter, Nicole Paczia, Hannes Link, Victor Sourjik   +7 more
doaj   +2 more sources

OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase

Cell Reports
Summary: Mitochondrial proteins are transported and sorted to the matrix or inner mitochondrial membrane by the presequence translocase TIM23. In yeast, this essential and highly conserved machinery is composed of the core subunits Tim23 and Tim17.
Praveenraj Elancheliyan, Klaudia K. Maruszczak, Remigiusz Adam Serwa, Till Stephan, Ahmet Sadik Gulgec, Mayra A. Borrero-Landazabal, Sonia Ngati, Aleksandra Gosk, Stefan Jakobs, Michal Wasilewski, Agnieszka Chacinska   +10 more
doaj   +2 more sources

The mitochondrial complexome of Medicago truncatula [PDF]

Frontiers in Plant Science, 2013
Legumes (Fabaceae, Leguminosae) are unique in their ability to carry out an elaborate endosymbiotic nitrogen fixation process with rhizobia proteobacteria.
Leonard Muriithi Kiirika, Christof eBehrens, Hans-Peter eBraun, Frank eColditz   +3 more
doaj   +4 more sources

mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage [PDF]

Cell Communication and Signaling
Introduction Cardiac mitochondrial function is intricately regulated by various processes, ultimately impacting metabolic performance. Additionally, protein turnover is crucial for sustained metabolic homeostasis in cardiomyocytes.
Hugo E. Verdejo, Valentina Parra, Andrea del Campo, Cesar Vasquez-Trincado, Damian Gatica, Camila Lopez-Crisosto, Jovan Kuzmicic, Leslye Venegas-Zamora, Ursula Zuñiga-Cuevas, Mayarling F. Troncoso, Rodrigo Troncoso, Beverly A. Rothermel, Mario Chiong, E. Dale Abel, Sergio Lavandero   +14 more
doaj   +2 more sources

Prohibitins in infection: potential therapeutic targets. [PDF]

Future Microbiol
Prohibitins (PHBs) are members of a highly conserved family of proteins, including prohibitin1 and prohibitin2. These proteins are predominantly localized in mitochondria, the nucleus, and cell membranes, where they play critical roles in mitochondrial biogenesis, apoptosis, immune regulation, and other biological processes.
Chen N, Liu X, Wang L, Yu H, Liu F, Yuan M, Wang Q, Zhang T, Zhou X, Wang H, Ji Z, Shen H.   +11 more
europepmc   +3 more sources

Prohibitins [PDF]

Current Biology, 2017
Tatsuta and Langer introduce prohibitins, membrane scaffolding proteins found predominantly in mitochondria.
Tatsuta, T., Langer, T.
openaire   +3 more sources

In situ architecture of the human prohibitin complex. [PDF]

Nat Cell Biol
AbstractProhibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, apoptosis, lifespan regulation and many others1, 2.
Lange F, Ratz M, Dohrke JN, Le Vasseur M, Wenzel D, Ilgen P, Riedel D, Jakobs S.   +7 more
europepmc   +7 more sources