Results 21 to 30 of about 2,450 (184)
Antioxidants, 2023 Recent studies have shown that FMS-like receptor tyrosine kinase 3 (Flt3) has a beneficial effect on cardiac maladaptive remodeling. However, the role and mechanism of Flt3 in mitochondrial dynamic imbalance under cardiac stress remains poorly understood.
Kaina Zhang +6 more
doaj +1 more source
Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases
Frontiers in Genetics, 2021 A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins
Misa Belser +2 more
doaj +1 more source
Mitophagy: Permitted by Prohibitin [PDF]
Current Biology, 2017 Autophagic responses specific for damaged or superfluous mitochondria are crucial for the maintenance of cellular and organismal homeostasis. Recent data demonstrate that components of the inner mitochondrial membrane that are unmasked upon outer membrane permeabilization facilitate the autophagic destruction of the organelle.
Lorenzo, Galluzzi +2 more
openaire +2 more sources
Ras-Raf Signaling Needs Prohibitin [PDF]
Cell Cycle, 2005 Prohibitin has been connected to diverse cellular functions including cell cycle control, senescence, apoptosis and stabilization of mitochondrial proteins. By employing a loss of function approach using siRNAs we have demonstrated an unexpected role of PHB in the activation of Raf/MEK/ERK pathway by active Ras and in modulating epithelial cell ...
Rajalingam, K., Rudel, T.
openaire +3 more sources
Development of prohibitin ligands against osteoporosis
European Journal of Medicinal Chemistry, 2021 Current therapeutic approaches to osteoporosis display some potential adverse effects and a limited efficacy on non-vertebral fracture reduction. Some sulfonylamidines targeting the scaffold proteins prohibitins-1 and 2 (PHB1/2) have been showed to inhibit the formation of osteoclasts in charge of bone resorption. Herein, we report the development of a
Tabti, Redouane +6 more
openaire +5 more sources
The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication. [PDF]
PLoS ONE, 2015 Apolipoprotein L9b (Apol9b) is an interferon-stimulated gene (ISG) that has antiviral activity and is weakly expressed in primary mouse neurons as compared to other cell types.
Marguerite Kreit +3 more
doaj +1 more source
Redox Biology, 2021 Background: Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are linked to several mitochondrial alterations. Cigarette smoke (CS) alters the structure and function of mitochondria.
Krishna Prahlad Maremanda +2 more
doaj +1 more source
Proteomic analysis of the rat ovary following chronic low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [PDF]
, 2009 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitously distributed endocrine-disrupting chemical and reproductive toxicant. In order to elucidate low-dose TCDD-mediated effects on reproductive or endocrine functions, female Sprague-Dawley rats were
Chen, X. +8 more
core +7 more sources
Involvement of prohibitin 1 and prohibitin 2 upregulation in cBSA-induced podocyte cytotoxicity
Journal of Food and Drug Analysis, 2020 Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults, when not effectively treated. The aim of this study was to discover new targets for the diagnosis and treatment of MN. A reliable mouse model of MN was used by the administration of cationic bovine serum albumin (cBSA).
Heng-Hsiung Wu +3 more
openaire +2 more sources
Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins
iScience, 2023 Summary: 5′-Adenosine monophosphate-activated protein kinase (AMPK) is a potential therapeutic target for various medical conditions. We here identify a small-molecule compound (RX-375) that activates AMPK and inhibits fatty acid synthesis in cultured ...
Shuhei Kanagaki +16 more
doaj +1 more source