Results 21 to 30 of about 2,442 (188)
Prohibitins in infection: potential therapeutic targets. [PDF]
Future MicrobiolProhibitins (PHBs) are members of a highly conserved family of proteins, including prohibitin1 and prohibitin2. These proteins are predominantly localized in mitochondria, the nucleus, and cell membranes, where they play critical roles in mitochondrial biogenesis, apoptosis, immune regulation, and other biological processes.
Chen N +11 more
europepmc +3 more sources
Mitophagy: Permitted by Prohibitin [PDF]
Current Biology, 2017 Autophagic responses specific for damaged or superfluous mitochondria are crucial for the maintenance of cellular and organismal homeostasis. Recent data demonstrate that components of the inner mitochondrial membrane that are unmasked upon outer membrane permeabilization facilitate the autophagic destruction of the organelle.
Lorenzo, Galluzzi +2 more
openaire +2 more sources
Mitochondrial prohibitin complex regulates fungal virulence via ATG24-assisted mitophagy
Communications Biology, 2022 Prohibitins recruit ChATG24 into the mitochondria to modulate mitophagy, thereby affecting the virulence of Colletotrichum higginsianum.
Yaqin Yan +9 more
doaj +1 more source
Ras-Raf Signaling Needs Prohibitin [PDF]
Cell Cycle, 2005 Prohibitin has been connected to diverse cellular functions including cell cycle control, senescence, apoptosis and stabilization of mitochondrial proteins. By employing a loss of function approach using siRNAs we have demonstrated an unexpected role of PHB in the activation of Raf/MEK/ERK pathway by active Ras and in modulating epithelial cell ...
Rajalingam, K., Rudel, T.
openaire +3 more sources
Development of prohibitin ligands against osteoporosis
European Journal of Medicinal Chemistry, 2021 Current therapeutic approaches to osteoporosis display some potential adverse effects and a limited efficacy on non-vertebral fracture reduction. Some sulfonylamidines targeting the scaffold proteins prohibitins-1 and 2 (PHB1/2) have been showed to inhibit the formation of osteoclasts in charge of bone resorption. Herein, we report the development of a
Tabti, Redouane +6 more
openaire +5 more sources
The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication. [PDF]
PLoS ONE, 2015 Apolipoprotein L9b (Apol9b) is an interferon-stimulated gene (ISG) that has antiviral activity and is weakly expressed in primary mouse neurons as compared to other cell types.
Marguerite Kreit +3 more
doaj +1 more source
Proteomic analysis of the rat ovary following chronic low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [PDF]
, 2009 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitously distributed endocrine-disrupting chemical and reproductive toxicant. In order to elucidate low-dose TCDD-mediated effects on reproductive or endocrine functions, female Sprague-Dawley rats were
Chen, X. +8 more
core +7 more sources
Redox Biology, 2021 Background: Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are linked to several mitochondrial alterations. Cigarette smoke (CS) alters the structure and function of mitochondria.
Krishna Prahlad Maremanda +2 more
doaj +1 more source
Involvement of prohibitin 1 and prohibitin 2 upregulation in cBSA-induced podocyte cytotoxicity
Journal of Food and Drug Analysis, 2020 Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults, when not effectively treated. The aim of this study was to discover new targets for the diagnosis and treatment of MN. A reliable mouse model of MN was used by the administration of cationic bovine serum albumin (cBSA).
Heng-Hsiung Wu +3 more
openaire +2 more sources
Prohibitins are required for cancer cell proliferation and adhesion.
PLoS ONE, 2010 Prohibitin 1 (PHB1) is a highly conserved protein that together with its homologue prohibitin 2 (PHB2) mainly localizes to the inner mitochondrial membrane.
Claudia Sievers +3 more
doaj +1 more source