Translation inhibition by rocaglates is independent of eIF4E phosphorylation status [PDF]
, 2016 Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have ...
Cencic, Regina +4 more
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Prohibitin-1 Transgenic Mice Revealed an Important Role of Prohibitin in Testicular Steroidogenesis
Journal of the Endocrine Society, 2021 Abstract Testosterone, the male sex hormone, plays an important role in the sexual development and fertility. Consequently, its deficiency causes infertility, obesity, osteoporosis and cardiovascular diseases. Leydig cells (LCs) are the testicular interstitial cells responsible for the biosynthesis of testosterone in response to ...
Bassi, Geetika, Mishra, Suresh
openaire +1 more source
Combined flow cytometry and high-throughput image analysis for the study of essential genes in Caenorhabditis elegans [PDF]
, 2018 Background: Advances in automated image-based microscopy platforms coupled with high-throughput liquid workflows have facilitated the design of large-scale screens utilising multicellular model organisms such as Caenorhabditis elegans to identify genetic
Artal Sanz, Marta +10 more
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Mitochondrial Quality Control Mechanisms and the PHB (Prohibitin) Complex
Cells, 2018 Mitochondrial functions are essential for life, critical for development, maintenance of stem cells, adaptation to physiological changes, responses to stress, and aging.
Blanca Hernando-Rodríguez +1 more
doaj +1 more source
Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion [PDF]
, 2009 Mitochondrial fusion requires the coordinated fusion of the outer and inner membranes. Three large GTPases—OPA1 and the mitofusins Mfn1 and Mfn2—are essential for the fusion of mammalian mitochondria.
David C. Chan +5 more
core +2 more sources
The function of prohibitins in mitochondria and the clinical potentials
Cancer Cell International, 2022 Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways.
Linda Oyang +14 more
doaj +1 more source
Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g [PDF]
, 2009 Crista junctions (CJs) are important for mitochondrial organization and function, but the molecular basis of their formation and architecture is obscure.
Al-Amoudi +77 more
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Prohibitins: A Critical Role in Mitochondrial Functions and Implication in Diseases
Cells, 2019 Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed, and are present in the nucleus, cytosol, and mitochondria.
Anna Signorile +3 more
doaj +1 more source
Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs [PDF]
, 2018 Rocaglamide has been reported to sensitize several cell types to TRAIL-induced apoptosis. In recent years, advances in synthetic techniques have led to generation of novel rocaglamide analogs.
Brown, Lauren E. +5 more
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The Role of Prohibitin-2 in Diseases
Frontiers in Bioscience-Landmark, 2023 Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis. Recently, there has been growing interest in the biological function of PHB2.
Fang Liu +3 more
openaire +3 more sources