Results 41 to 50 of about 2,450 (184)
Downregulation of lung mitochondrial prohibitin in COPD [PDF]
Respiratory Medicine, 2012 Prohibitins (PHB1 and PHB2) are versatile proteins located at the inner mitochondrial membrane, maintaining normal mitochondrial function and morphology. They interact with the NADH dehydrogenase protein complex, which is essential for oxidoreductase activity within cells. However, their expression in lung epithelium, especially in smokers and patients
Soulitzis, Nikolaos +6 more
openaire +2 more sources
The Identification of Prohibitin in the Rat Heart Mitochondria in Heart Failure
Biomedicines, 2021 Mitochondria are considered the main organelles in the cell. They play an important role in both normal and abnormal heart function. There is a supramolecular organization between the complexes of the respiratory chain (supercomplexes (SCs)), which are ...
Yulia Baburina +5 more
doaj +1 more source
Life without complex I: proteome analyses of an Arabidopsis mutant lacking the mitochondrial NADH dehydrogenase complex [PDF]
, 2016 The mitochondrial NADH dehydrogenase complex (complex I) is of particular importance for the respiratory chain in mitochondria. It is the major electron entry site for the mitochondrial electron transport chain (mETC) and therefore of great significance ...
Braun, Hans-Peter +4 more
core +2 more sources
Disruption of Mitochondrial Dynamics and Integrity Drives Divergent Metabolic Flexibility and Resilience in Podocytes. [PDF]
FASEB JWe investigated two models of mitochondrial dysfunction in podocytes, using two cell culture models: podocytes isolated from mice with Oma1 deletion (Oma1del) and mouse podocytes modified with an inducible knockdown of PHB2 (Phb2kd). OMA1 deficiency induced a glycolytic shift, enhanced glutamine anaplerosis, and sustained energy homeostasis after ...
Özel C +13 more
europepmc +2 more sources
The role of prohibitin in cell signaling [PDF]
The FEBS Journal, 2010 Prohibitin‐1 (PHB, also known as PHB1), a member of the Band‐7 family of proteins, is highly conserved evolutionarily, widely expressed, and present in different cellular compartments. Genetic studies with different organism models have provided strong evidence for an important biological role of PHB in mitochondrial function, cell proliferation, and ...
Suresh, Mishra +2 more
openaire +2 more sources
Mitochondrial Band-7 family proteins: scaffolds for respiratory chain assembly?
Frontiers in Plant Science, 2014 The band-7 protein family comprises a diverse set of membrane-bound proteins characterised by the presence of a conserved domain. The exact function of this band-7 domain remains elusive, but examples from animal and bacterial stomatin-type proteins ...
Bernadette eGehl, Lee James Sweetlove
doaj +1 more source
Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells. [PDF]
PLoS ONE, 2012 Increase in mitochondrial biogenesis has been shown to accompany brown and white adipose cell differentiation. Prohibitins (PHBs), comprised of two evolutionarily conserved proteins, prohibitin-1 (PHB1) and prohibitin-2 (PHB2), are present in a high ...
Dong Liu +9 more
doaj +1 more source
Inhibitors of Pyruvate Carboxylase [PDF]
, 2010 This review aims to discuss the varied types of inhibitors of biotin-dependent carboxylases, with an emphasis on the inhibitors of pyruvate carboxylase.
Attwood, Paul V. +2 more
core +2 more sources
Parasites & Vectors, 2018 Background Leishmaniasis, a disease caused by parasites of the genus Leishmania, infects roughly 12 million people worldwide, with about two million new cases per year. Prohibitins (PHBs) are highly conserved proteins belonging to the stomatin-prohibitin
Teresa Cruz-Bustos +4 more
doaj +1 more source
Biological and Cellular Functions of the Microdomain-Associated FWL/CNR Protein Family in Plants
Plants, 2020 Membrane microdomains/nanodomains are sub-compartments of the plasma membrane enriched in sphingolipids and characterized by their unique protein composition.
Sandra Thibivilliers +2 more
doaj +1 more source