A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation [PDF]
, 2016 We previously described diaryl trifluorothiazoline compound 1a (hereafter referred to as fluorizoline) as a first-in-class small molecule that induces p53-independent apoptosis in a wide range of tumor cell lines.
Albericio Palomera, Fernando +15 more
core +1 more source
The Prohibitins: emerging roles in diverse functions [PDF]
Journal of Cellular and Molecular Medicine, 2006 The prohibitins, Phb1 and Phb2 are highly conserved proteins in eukaryotic cells that are present in multiple cellular compartments. Initial investigations focused on the role of Phb1 as an inhibitor of cell proliferation hence the original name prohibitin.
Mishra, Suresh +2 more
openaire +2 more sources
Skp2 and Skp2B team up against Rb and p53. [PDF]
, 2011 The Skp2 locus encodes two proteins, Skp2 and Skp2B. The role of Skp2 in the ubiquitin-dependent degradation of key regulators of the retinoblastoma protein pathway has been well established.
Doris Germain
core +1 more source
Unveiling the potential of prohibitin in cancer [PDF]
Cancer Letters, 2015 Recently, research has shed new light on the role of Prohibitin (PHB) in cancer pathogenesis across an array of cancer types. Important mechanisms for PHB have been unveiled in several cancers, especially with regard to the androgen independent state of prostate cancer (PC) and oestrogen dependent breast cancer.
Koushyar, Sarah +2 more
openaire +2 more sources
Translocator Protein-Mediated Stabilization of Mitochondrial Architecture during Inflammation Stress in Colonic Cells. [PDF]
, 2015 International audienceChronic inflammation of the gastrointestinal tract increasing the risk of cancer has been described to be linked to the high expression of the mitochondrial translocator protein (18 kDa; TSPO).
Benoist, Jean-François +9 more
core +6 more sources
PLoS Genetics, 2012 Fusion and fission of mitochondria maintain the functional integrity of mitochondria and protect against neurodegeneration, but how mitochondrial dysfunctions trigger neuronal loss remains ill-defined.
Carsten Merkwirth +7 more
doaj +1 more source
FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity. [PDF]
PLoS ONE, 2015 The clinical use of doxorubicin for the treatment of cancer is limited by its cardiotoxicity. Flavaglines are natural products that have both potent anticancer and cardioprotective properties.
Rehana Qureshi +7 more
doaj +1 more source
Role of ERLINs in the Control of Cell Fate through Lipid Rafts
Cells, 2021 ER lipid raft-associated protein 1 (ERLIN1) and 2 (ERLIN2) are 40 kDa transmembrane glycoproteins belonging to the family of prohibitins, containing a PHB domain.
Valeria Manganelli +9 more
doaj +1 more source
Intramolecular Cyclization of N-phenyl N'(2-chloroethyl)ureas leads to Active N-phenyl-4,5-dihydrooxazol-2-amines Alkylating β-Tubulin Glu198 and Prohibitin Asp40 [PDF]
, 2011 International audienceThe cyclization of anticancer drugs into active intermediates has been reported mainly for DNA alkylating molecules including nitrosoureas.
Bouchon, Bernadette +10 more
core +4 more sources
Prohibitin (PHB) roles in granulosa cell physiology [PDF]
Cell and Tissue Research, 2015 Ovarian granulosa cells (GC) play an important role in the growth and development of the follicle in the process known as folliculogenesis. In the present review, we focus on recent developments in prohibitin (PHB) research in relation to GC physiological functions.
Indrajit, Chowdhury +2 more
openaire +2 more sources