Results 61 to 70 of about 2,450 (184)
Prohibitin (PHB) roles in granulosa cell physiology [PDF]
Cell and Tissue Research, 2015 Ovarian granulosa cells (GC) play an important role in the growth and development of the follicle in the process known as folliculogenesis. In the present review, we focus on recent developments in prohibitin (PHB) research in relation to GC physiological functions.
Indrajit, Chowdhury +2 more
openaire +2 more sources
Structure-function analysis of human stomatin: A mutation study. [PDF]
PLoS ONE, 2017 Stomatin is an ancient, widely expressed, oligomeric, monotopic membrane protein that is associated with cholesterol-rich membranes/lipid rafts. It is part of the SPFH superfamily including stomatin-like proteins, prohibitins, flotillin/reggie proteins ...
Stefanie Rungaldier +5 more
doaj +1 more source
Characterization and functional analysis of the proteins Prohibitin 1 and 2 in Trypanosoma cruzi.
PLoS Neglected Tropical Diseases, 2021 BackgroundChagas disease is the third most important neglected tropical disease. There is no vaccine available, and only two drugs are generally prescribed for the treatment, both of which with a wide range of side effects. Our study of T.
Ana K Ibarrola-Vannucci +8 more
doaj +1 more source
Intramolecular Cyclization of N-phenyl N'(2-chloroethyl)ureas leads to Active N-phenyl-4,5-dihydrooxazol-2-amines Alkylating β-Tubulin Glu198 and Prohibitin Asp40 [PDF]
, 2011 International audienceThe cyclization of anticancer drugs into active intermediates has been reported mainly for DNA alkylating molecules including nitrosoureas.
Bouchon, Bernadette +10 more
core +4 more sources
Renal Failure, 2013 Prohibitin (PHB), a ubiquitous protein, plays a number of different molecular functions, and it is mainly located on the inner mitochondrial membrane and nuclei.
Tian-Biao, Zhou, Yuan-Han, Qin
openaire +2 more sources
Prohibitin 1 in liver injury and cancer
Experimental Biology and Medicine, 2020 Prohibitin 1 is an evolutionary conserved and ubiquitously expressed protein that exerts different biological functions depending on its subcellular localization. The role of prohibitin 1 in liver cancer is controversial as it can be pro- or anti-tumorigenic.
Lucía Barbier-Torres, Shelly C Lu
openaire +5 more sources
Advanced Science, EarlyView.The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang +9 more
wiley +1 more source
Structural and functional comparisons of retroviral envelope protein C-terminal domains: Still much to learn [PDF]
, 2014 Retroviruses are a family of viruses that cause a broad range of pathologies in animals and humans, from the apparently harmless, long-term genomic insertion of endogenous retroviruses, to tumors induced by the oncogenic retroviruses and acquired ...
Kuhlmann, AS +2 more
core +2 more sources
Advanced Science, EarlyView.Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu +7 more
wiley +1 more source
Cellular Signalling, 2011 Prohibitin 2 (PHB2) is an evolutionarily conserved and ubiquitously expressed multifunctional protein which is present in various cellular compartments including the nucleus. However, mechanisms underlying various functions of PHB2 are not fully explored yet.
Sun, Luguo +7 more
openaire +2 more sources