Results 71 to 80 of about 2,442 (188)

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

CaMK IV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription

Cellular Signalling, 2011
Prohibitin 2 (PHB2) is an evolutionarily conserved and ubiquitously expressed multifunctional protein which is present in various cellular compartments including the nucleus. However, mechanisms underlying various functions of PHB2 are not fully explored yet.
Sun, Luguo, Cao, Xia, Liu, Bin, Huang, Honglan, Wang, Xu, Sui, Liyan, Yin, Weimin, Ma, Kewei   +7 more
openaire   +2 more sources

Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Barth syndrome (BTHS) is a rare X‐linked mitochondrial disorder caused by mutations in the TAFAZZIN gene, which disrupts cardiolipin (CL) remodelling and mitochondrial function. While cardiac manifestations of BTHS are well characterized in male patients, the mechanisms underlying skeletal muscle weakness and fatigability are poorly
Catalina Matias, Paige L. Snider, Elizabeth A. Sierra Potchanant, Joshua R. Huot, Rahul Raghav, Michael T. Chin, Simon J. Conway, Jeffrey J. Brault   +7 more
wiley   +1 more source

Skp2B attenuates p53 function by inhibiting prohibitin [PDF]

EMBO reports, 2010
The F‐box protein Skp2 and its isoform Skp2B are both overexpressed in breast cancers. Skp2 alters the activity of p53 by inhibiting its interaction with p300 and by promoting p300 degradation. Here, we report that Skp2B also attenuates the activity of p53; however, this effect is independent of p300, suggesting that another mechanism might be involved.
Harish, Chander, Max, Halpern, Lois, Resnick-Silverman, James J, Manfredi, Doris, Germain   +4 more
openaire   +2 more sources

Role of prohibitins for proteolysis in yeast and murine mitochondria [PDF]

, 2006
Prohibitins, Phb1 and Phb2, are evolutionary conserved proteins with diverse cellular localization and different functions. In yeast, prohibitins form a high molecular weight complex in the inner mitochondrial membrane which physically interacts with the
Metodiev, Metodi Dimitrov
core  

The complexities of respiratory chain biogenesis and maintenance in yeast mitochondria

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial oxidative phosphorylation is the most efficient way of energy conversion for eukaryotic cells. It is executed by a series of high‐molecular weight enzyme complexes in the inner mitochondrial membrane that were acquired during endosymbiosis at the root of eukaryotic evolution.
Andreas Carlström, Carmela Vazquez‐Calvo, Martin Ott   +2 more
wiley   +1 more source

Prohibitin 1 modulates mitochondrial function of Stat3 [PDF]

Cellular Signalling, 2014
Mitochondrial dysfunction in intestinal epithelial cells (IEC) is thought to precede the onset of inflammatory bowel diseases (IBD). Expression of Prohibitin 1 (PHB), a mitochondrial protein required for optimal electron transport chain (ETC) activity, is decreased in mucosal biopsies during active and inactive IBD.
Jie, Han, Chunhua, Yu, Rhonda F, Souza, Arianne L, Theiss   +3 more
openaire   +2 more sources

Mitochondrial and chloroplast stress responses are modulated in distinct touch and chemical inhibition phases [PDF]

, 2016
Previous studies have identified a range of transcription factors that modulate retrograde regulation of mitochondrial and chloroplast functions in Arabidopsis (Arabidopsis thaliana).
De Clercq, Inge, Ivanova, Aneta, Law, Simon R, Millar, A Harvey, Van Aken, Olivier, Van Breusegem, Frank, Whelan, James   +6 more
core   +2 more sources

Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants

Advanced Science, Volume 13, Issue 14, 9 March 2026.
In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao, Yanbin Li, Shengqi Zhang, Yilin He, Zhiqi Liu, Juan Wang, Jingmin Hua, Jinyu Chen, Junru Zhong, Huan Zhong, Yiji Xia, Yong Cui, Liwen Jiang   +12 more
wiley   +1 more source

Mitochondrial Ca uptake correlates with the severity of the symptoms in autosomal dominant optic atrophy. [PDF]

, 2015
The most frequent form of hereditary blindness, autosomal dominant optic atrophy (ADOA), is caused by the mutation of the mitochondrial protein Opa1 and the ensuing degeneration of retinal ganglion cells.
Alavi, Alexander, Amati-Bonneau, Amutha, András Spät, Anikó Rajki, Arnoult, Baughman, Belenguer, Bernardi, Bernardi, Bette, Chevrollier, Cipolat, Dayanithi, De Stefani, Delettre, Delettre, Duchen, Erika Maka, Frey, Frezza, Fülöp, Fülöp, Gilkerson, Griparic, Griparic, Hoffman, Hudson, Ishihara, Kjer, Kushnareva, Lenaers, Leruez, Liesa, Lodi, Loncar, László Fülöp, Marchi, Merkwirth, Mária Judit Molnár, Olichon, Olichon, Palmer, Patron, Pendin, Perotti, Piquereau, Russo, Satoh, Schaaf, Schoenmakers, Scorrano, Sesaki, Song, Spät, Votruba, Williams, Wong, Yamaguchi, Yu-Wai-Man, Zanna, Zoratti   +62 more
core   +1 more source