Results 71 to 80 of about 2,450 (184)
A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. [PDF]
, 2011 To broadly explore mitochondrial structure and function as well as the communication of mitochondria with other cellular pathways, we constructed a quantitative, high-density genetic interaction map (the MITO-MAP) in Saccharomyces cerevisiae.
Cassidy-Stone, Ann +9 more
core +2 more sources
Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse
Experimental Physiology, EarlyView.Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Skp2B attenuates p53 function by inhibiting prohibitin [PDF]
EMBO reports, 2010 The F‐box protein Skp2 and its isoform Skp2B are both overexpressed in breast cancers. Skp2 alters the activity of p53 by inhibiting its interaction with p300 and by promoting p300 degradation. Here, we report that Skp2B also attenuates the activity of p53; however, this effect is independent of p300, suggesting that another mechanism might be involved.
Harish, Chander +4 more
openaire +2 more sources
The alternative Medicago truncatula defense proteome of ROS - defective transgenic roots during early microbial infection [PDF]
, 2014 ROP-type GTPases of plants function as molecular switches within elementary signal transduction pathways such as the regulation of ROS synthesis via activation of NADPH oxidases (RBOH-respiratory burst oxidase homolog in plants).
Colditz, Frank +2 more
core +7 more sources
Role of prohibitins for proteolysis in yeast and murine mitochondria [PDF]
, 2006 Prohibitins, Phb1 and Phb2, are evolutionary conserved proteins with diverse cellular localization and different functions. In yeast, prohibitins form a high molecular weight complex in the inner mitochondrial membrane which physically interacts with the
Metodiev, Metodi Dimitrov
core
From isolation to insights: mitochondrial complex I in the diatom Phaeodactylum tricornutum
The Plant Journal, Volume 125, Issue 3, February 2026.SUMMARY Diatoms are among the most ecologically successful microalgae, contributing significantly to marine primary production and global carbon cycling. Their distinctive metabolic architecture, shaped by a complex evolutionary history involving secondary endosymbiosis, includes a highly compartmentalized cell organization and unique metabolic ...
Federico Berdun +7 more
wiley +1 more source
Prohibitin 1 modulates mitochondrial function of Stat3 [PDF]
Cellular Signalling, 2014 Mitochondrial dysfunction in intestinal epithelial cells (IEC) is thought to precede the onset of inflammatory bowel diseases (IBD). Expression of Prohibitin 1 (PHB), a mitochondrial protein required for optimal electron transport chain (ETC) activity, is decreased in mucosal biopsies during active and inactive IBD.
Jie, Han +3 more
openaire +2 more sources
A Rare NPHS2 Mutation (E130K) in Hereditary Steroid‐Resistant Nephrotic Syndrome: A Case Report
Case Reports in Nephrology, Volume 2026, Issue 1, 2026.Hereditary steroid‐resistant nephrotic syndrome (HSRNS) due to mutations in the NPHS2 gene (encoding podocin) is a rare genetic condition that typically presents in childhood. We report a case of a 2‐year‐and‐8‐month‐old male, the seventh child of consanguineous parents, who presented with recurrent fever, febrile tonic‐clonic seizures, and periorbital
Ramzi Hmedan Mujahed +7 more
wiley +1 more source
Mitochondrial and chloroplast stress responses are modulated in distinct touch and chemical inhibition phases [PDF]
, 2016 Previous studies have identified a range of transcription factors that modulate retrograde regulation of mitochondrial and chloroplast functions in Arabidopsis (Arabidopsis thaliana).
De Clercq, Inge +6 more
core +2 more sources