Results 81 to 90 of about 2,450 (184)

Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Characterized by its capacity to induce organ failure, sepsis constitutes a life‐threatening pathological state with high incidence and mortality rates. Current treatments primarily focus on antimicrobial therapy and organ support, lacking direct interventions targeting the restoration of cellular or organelle function.
Xiangxin Liao, Yixun Wang, Zhaohui Zhang, Xingguang Qu, Gaosheng Zhou, Laurent L′homme   +5 more
wiley   +1 more source

“Prohibitin”g CRAF/MAPK Activation with Rocaglamides

Chemistry & Biology, 2012
Interaction with prohibitin (PHB) is required for full activation of CRAF kinase, the central member of the highly conserved RAS-CRAF-MAPK pathway. In this issue of Chemistry & Biology, Polier et al. show that the natural anti-tumor compounds rocaglamides target the CRAF-PHB interaction to disrupt the MAPK pathway leading to proliferation block in ...
Rajalingam, Krishnaraj, Rudel, Thomas
openaire   +2 more sources

Prohibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegans. [PDF]

PLoS ONE, 2014
Lifespan regulation by mitochondrial proteins has been well described, however, the mechanism of this regulation is not fully understood. Amongst the mitochondrial proteins profoundly affecting ageing are prohibitins (PHB-1 and PHB-2).
Roxani Gatsi, Bettina Schulze, María Jesús Rodríguez-Palero, Blanca Hernando-Rodríguez, Ralf Baumeister, Marta Artal-Sanz   +5 more
doaj   +1 more source

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 23: Suitability of taxonomic units notified to EFSA until September 2025

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The qualified presumption of safety (QPS) process was developed to provide a harmonised safety assessment approach to support EFSA Scientific Panels and Units. The QPS approach assesses the taxonomic identity, body of relevant knowledge and safety of microorganisms intentionally added to the food and feed chain.
EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Marianne Chemaly, Pier Sandro Cocconcelli, Pablo Salvador Fernández Escámez, Miguel Prieto Maradona, Amparo Querol, Lolke Sijtsma, Juan Evaristo Suarez, Ingvar Sundh, Fulvio Barizzone, Justine Dastouet, Nadya Doyle, Sandra Correia, Lieve Herman   +28 more
wiley   +1 more source

Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region

iScience, 2019
Summary: The coiled-coil motif mediates subunit oligomerization and scaffolding and underlies several fundamental biologic processes. Prohibitins (PHBs), mitochondrial inner membrane proteins involved in mitochondrial homeostasis and signal transduction,
Takahiro Yoshinaka, Hidetaka Kosako, Takuma Yoshizumi, Ryo Furukawa, Yu Hirano, Osamu Kuge, Taro Tamada, Takumi Koshiba   +7 more
doaj   +1 more source

Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility? [PDF]

, 2012
Prohibitin (PHB) is a highly conserved major sperm mitochondrial membrane protein whose absence in somatic cells is associated with mitochondrial membrane depolarization and increased generation of reactive oxygen species (ROS).
Chen, GW, Chen, H, Martin-DeLeon, PA, O, WS, Ou, JX, Shi, HJ, Wang, MJ, Wu, JP   +7 more
core   +1 more source

Mitochondrial Ca uptake correlates with the severity of the symptoms in autosomal dominant optic atrophy. [PDF]

, 2015
The most frequent form of hereditary blindness, autosomal dominant optic atrophy (ADOA), is caused by the mutation of the mitochondrial protein Opa1 and the ensuing degeneration of retinal ganglion cells.
Alavi, Alexander, Amati-Bonneau, Amutha, András Spät, Anikó Rajki, Arnoult, Baughman, Belenguer, Bernardi, Bernardi, Bette, Chevrollier, Cipolat, Dayanithi, De Stefani, Delettre, Delettre, Duchen, Erika Maka, Frey, Frezza, Fülöp, Fülöp, Gilkerson, Griparic, Griparic, Hoffman, Hudson, Ishihara, Kjer, Kushnareva, Lenaers, Leruez, Liesa, Lodi, Loncar, László Fülöp, Marchi, Merkwirth, Mária Judit Molnár, Olichon, Olichon, Palmer, Patron, Pendin, Perotti, Piquereau, Russo, Satoh, Schaaf, Schoenmakers, Scorrano, Sesaki, Song, Spät, Votruba, Williams, Wong, Yamaguchi, Yu-Wai-Man, Zanna, Zoratti   +62 more
core   +1 more source

Selective Lipolysis by Photoactivation of Chaperone‐Mediated Autophagy Using Adipocyte Membrane‐Coated Nanoparticle in Hydrogel

Advanced Materials, Volume 37, Issue 49, December 10, 2025.
Adipocyte membrane‐coated nanoparticles loaded with rosiglitazone in hydrogel offer an alternative approach to conventional obesity treatments. This system selectively targets adipocytes, inducing lipolysis by activating chaperone‐mediated autophagy through mild photothermal stimulation.
Jaehyun Choi, Junho Byun, Dongyoon Kim, Qiaoyun Li, Dongun Jin, Yeong‐jin Choi, Ho Sang Jung, Jaiwoo Lee, Yu‐Kyoung Oh   +8 more
wiley   +1 more source

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Silencing a prohibitin alters plant development and senescence [PDF]

The Plant Journal, 2005
SummaryProhibitins, highly conserved mitochondrial proteins, have been shown to play important roles in cell cycling and senescence in animals and yeast. Sequences with high similarity to prohibitins have been identified in a number of plant species, but their function has not yet been demonstrated. The deduced amino acid sequences of PhPHB1 and PhPHB2,
Jen-Chih, Chen, Cai-Zhong, Jiang, Michael S, Reid   +2 more
openaire   +2 more sources