Results 81 to 90 of about 2,442 (188)
Advanced Science, Volume 13, Issue 16, 18 March 2026.Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao +3 more
wiley +1 more source
“Prohibitin”g CRAF/MAPK Activation with Rocaglamides
Chemistry & Biology, 2012 Interaction with prohibitin (PHB) is required for full activation of CRAF kinase, the central member of the highly conserved RAS-CRAF-MAPK pathway. In this issue of Chemistry & Biology, Polier et al. show that the natural anti-tumor compounds rocaglamides target the CRAF-PHB interaction to disrupt the MAPK pathway leading to proliferation block in ...
Rajalingam, Krishnaraj, Rudel, Thomas
openaire +2 more sources
Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility? [PDF]
, 2012 Prohibitin (PHB) is a highly conserved major sperm mitochondrial membrane protein whose absence in somatic cells is associated with mitochondrial membrane depolarization and increased generation of reactive oxygen species (ROS).
Chen, GW +7 more
core +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Prohibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegans. [PDF]
PLoS ONE, 2014 Lifespan regulation by mitochondrial proteins has been well described, however, the mechanism of this regulation is not fully understood. Amongst the mitochondrial proteins profoundly affecting ageing are prohibitins (PHB-1 and PHB-2).
Roxani Gatsi +5 more
doaj +1 more source
Alms1 KO Rat: A New Model of Cardiometabolic Syndrome With Spontaneous Hypertension
Acta Physiologica, Volume 242, Issue 3, March 2026.ABSTRACT Alström syndrome 1 (ALMS1) is a protein linked to Alström syndrome, a rare genetic disorder characterized by obesity, insulin resistance, hyperinsulinemia, and hypertension. Genetic studies have further associated Alms1 with hypertension in human populations. However, the precise mechanisms by which ALMS1 regulates metabolic and cardiovascular
Ankita B. Jaykumar +6 more
wiley +1 more source
iScience, 2019 Summary: The coiled-coil motif mediates subunit oligomerization and scaffolding and underlies several fundamental biologic processes. Prohibitins (PHBs), mitochondrial inner membrane proteins involved in mitochondrial homeostasis and signal transduction,
Takahiro Yoshinaka +7 more
doaj +1 more source
Skin Colour in Salamanders Is Modulated by Both Epitranscriptomic Methylation and Gene Expression
Molecular Ecology, Volume 35, Issue 6, March 2026.ABSTRACT Animal colouration is a key trait in organismal biology, being involved in natural and sexual selection, competition, and communication. Amphibians use their highly diverse colouration in many ecological interactions, but the molecular bases of their colour variation are less well understood than in other vertebrate systems. While the genetic,
Nicholas Strowbridge +3 more
wiley +1 more source
From isolation to insights: mitochondrial complex I in the diatom Phaeodactylum tricornutum
The Plant Journal, Volume 125, Issue 3, February 2026.SUMMARY Diatoms are among the most ecologically successful microalgae, contributing significantly to marine primary production and global carbon cycling. Their distinctive metabolic architecture, shaped by a complex evolutionary history involving secondary endosymbiosis, includes a highly compartmentalized cell organization and unique metabolic ...
Federico Berdun +7 more
wiley +1 more source
Silencing a prohibitin alters plant development and senescence [PDF]
The Plant Journal, 2005 SummaryProhibitins, highly conserved mitochondrial proteins, have been shown to play important roles in cell cycling and senescence in animals and yeast. Sequences with high similarity to prohibitins have been identified in a number of plant species, but their function has not yet been demonstrated. The deduced amino acid sequences of PhPHB1 and PhPHB2,
Jen-Chih, Chen +2 more
openaire +2 more sources