Results 1 to 10 of about 6,114 (163)

Expression of Properdin, the positive regulator of the Complement Alternative Pathway, at the fetal-maternal interface in Preeclampsia [PDF]

Frontiers in Immunology
IntroductionAberrant complement activation can cause damage to newly formed fetal-derived structures and excessive inflammatory response at the feto-maternal interface, contributing to pregnancy-related complications, including preeclampsia (PE), which ...
Hadida Yasmin, Tamali Roy, Chiara Agostinis, Aishwarya Rao, Priyanka Sharma, Miriam Toffoli, Andrea Balduit, Silvia Pegoraro, Samik Bindu, Rajib Prasad, Giuseppe Ricci, Giuseppe Ricci, Manu Vatish, Taruna Madan, Taruna Madan, Roberta Bulla, Uday Kishore   +16 more
doaj   +2 more sources

Infiltrating myeloid cell-derived properdin markedly promotes microglia-mediated neuroinflammation after ischemic stroke [PDF]

Journal of Neuroinflammation, 2023
Background Emerging evidence has shown that myeloid cells that infiltrate into the peri-infarct region may influence the progression of ischemic stroke by interacting with microglia.
Pin-yi Liu, Hui-qin Li, Meng-qi Dong, Xin-ya Gu, Si-yi Xu, Sheng-nan Xia, Xin-yu Bao, Yun Xu, Xiang Cao   +8 more
doaj   +2 more sources

Differential expression of complement Properdin and Factor H in the placentae and umbilical cords of mothers with Preeclampsia, Gestational Diabetes Mellitus and Recurrent Pregnancy Loss [PDF]

Frontiers in Immunology
BackgroundProperdin and factor H (FH), the two regulatory proteins of the alternative complement pathway, oppose each other to maintain the complement system’s activation.
Tamali Roy, Ananya Das, Nabanita Chatterjee, Shyama Prasad Saha, Rajib Prasad, Taruna Madan, Hadida Yasmin, Uday Kishore   +7 more
doaj   +2 more sources

Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw”

Frontiers in Immunology, 2013
Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilising the C3bBb complex, whereas factor H down-regulates the pathway by ...
Cordula M Stover, Robert B Sim, Uday Kishore   +2 more
exaly   +3 more sources

Alternative Complement Pathway in Carotid Atherosclerosis: Low Plasma Properdin Levels Associate With Long‐Term Cardiovascular Mortality [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in ...
Mieke C. Louwe, Chrysostomi Gialeli, Annika E. Michelsen, Sverre Holm, Andreas Edsfeldt, Karolina Skagen, Tove Lekva, Maria Belland Olsen, Vigdis Bjerkeli, Therese Schjørlien, Kristine Stø, Xiang Yi Kong, Tuva B. Dahl, Per H. Nilsson, Peter Libby, Pål Aukrust, Tom Eirik Mollnes, Thor Ueland, Mona Skjelland, Isabel Gonçalves, Bente Halvorsen   +20 more
doaj   +2 more sources

Structure and function of a family of tick-derived complement inhibitors targeting properdin

Nature Communications, 2022
Properdin is the only known positive regulator of the human complement system, stabilising the convertase C3 in the alternative pathway of complement activation.
Katharina Braunger, Matthijs M Jore, Steven J Johnson   +2 more
exaly   +2 more sources

Prognostic Value of Complement Properdin in Cancer

Frontiers in Immunology, 2021
The complement system is readily triggered by the presence of damage-associated molecular patterns on the surface of tumor cells. The complement alternative pathway provides rapid amplification of the molecular stress signal, leading to complement ...
Alessandro Mangogna, Praveen Mathews Varghese, Chiara Agostinis   +2 more
exaly   +3 more sources

Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation

Frontiers in Immunology, 2020
The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation.
Jin Chen, Joshua M Thurman, Robert A Brodsky   +2 more
exaly   +3 more sources

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Frontiers in Immunology, 2019
Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the ...
Nicholas M Pearce, Harma Brondijk, Piet Gros   +2 more
exaly   +3 more sources

Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement

Frontiers in Immunology, 2013
Properdin, the only positive regulatory protein of the complement system, acts as both a stabilizer of the alternative pathway convertases and as a selective pattern recognition molecule of certain microorganisms and host cells (i.e.
Gurpanna Saggu, Viviana P Ferreira
exaly   +3 more sources