Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study. [PDF]
Clin Transl SciABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Sandhu A +8 more
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Regulation of the terminal complement cascade in adipose tissue for control of its volume, cellularity, and fibrosis. [PDF]
Obesity (Silver Spring)Abstract White adipose tissue (WAT) is a reservoir for various pathogens and their products, such as lipopolysaccharides. Therefore, it must be equipped with a defense mechanism connected with the activation of innate immunity. This explains the phenomenon that adipocytes express components of the classical and alternative complement pathways, which ...
Kruglikov IL, Scherer PE.
europepmc +2 more sources
CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment. [PDF]
Alzheimers Dement (N Y)Abstract INTRODUCTION Brain steady‐state gamma oscillations evoked using a non‐invasive medical device (Spectris) have shown potential clinical benefits in patients with mild–moderate Alzheimer's disease (AD), including reduced functional and cognitive decline, reduced brain volume and myelin loss, and increased brain functional connectivity.
Hajós M +10 more
europepmc +2 more sources
Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20 [PDF]
, 2020 Introduction: Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin has shown to bind to heparan sulfate proteoglycans on tubular epithelium and can
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THE PROPERDIN SYSTEM AND IMMUNITY [PDF]
The Journal of Experimental Medicine, 1956 A detailed method for the zymosan assay of properdin is described, together with procedures for the preparation and standardization of reagents employed in the test. The reliability and reproducibility of the assay, as well as its limitations, are discussed.
Earl W. Todd +4 more
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Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells [PDF]
, 2022 Properdin, the only known positive regulator of the complement system, stabilizes the C3 convertase, thereby increasing its half-life. In contrast to most other complement factors, properdin is mainly produced extrahepatically by myeloid cells.
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Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]
, 2013 This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M +5 more
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Studies on relationship between serum properdin and cancer I. A modified method for the assay of serum properdin [PDF]
, 1961 1. Properdin assay which is comparatively sensitive and reproducible has been described. The assay may be called a modified method of properdin assay by HUNTER·HILL and McNALL. 2.
Orita, Kunzo
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Studies on relationship between serum properdin and cancer III. Influence of anticancer agents on the serum properdin level [PDF]
, 1961 1. When the various anticancer agents are injected intravenously to normal rabbits and intraperitoneally to normal mice, it seems that the serum properdin levels fall transitorily for some hours after administration with a small dose and then keep rising,
Orita, Kunzo
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Studies on relationship between serum properdin and cancer II. Studies on the serum properdin levels of tumor bearing animals and patients with malignant tumors [PDF]
, 1961 1. The properdin levels in sera from mice bearing Ehrlich ascitic carcinoma and from rabbits with Brown-Pearce carcinoma decrease inversely with the increase of the ascites or the tumors. In the incipient period of tumor transplantation, the level rather
Orita, Kunzo
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