Results 1 to 10 of about 10,182 (218)

Infiltrating myeloid cell-derived properdin markedly promotes microglia-mediated neuroinflammation after ischemic stroke [PDF]

Journal of Neuroinflammation, 2023
Background Emerging evidence has shown that myeloid cells that infiltrate into the peri-infarct region may influence the progression of ischemic stroke by interacting with microglia.
Pin-yi Liu, Hui-qin Li, Meng-qi Dong, Xin-ya Gu, Si-yi Xu, Sheng-nan Xia, Xin-yu Bao, Yun Xu, Xiang Cao   +8 more
doaj   +5 more sources

A novel assay that characterizes properdin function shows neutrophil-derived properdin has a distinct oligomeric distribution [PDF]

Frontiers in Immunology, 2023
Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore, Smrithi S. Menon, Neeti S. Galwankar, Sadik A. Khuder, Michael K. Pangburn, Viviana P. Ferreira   +5 more
doaj   +3 more sources

Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy [PDF]

Frontiers in Immunology, 2019
C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of the alternative pathway (AP) of the complement
Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Ramon M. van den Bos, Thea J. A. M. van der Velden, Sanne A. W. van Kraaij, Sebastian A. Sarlea, Valentina Gracchi, Michiel J. S. Oosterveld, Elena B. Volokhina, Elena B. Volokhina, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel   +12 more
doaj   +3 more sources

Alternative Complement Pathway in Carotid Atherosclerosis: Low Plasma Properdin Levels Associate With Long‐Term Cardiovascular Mortality [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in ...
Mieke C. Louwe, Chrysostomi Gialeli, Annika E. Michelsen, Sverre Holm, Andreas Edsfeldt, Karolina Skagen, Tove Lekva, Maria Belland Olsen, Vigdis Bjerkeli, Therese Schjørlien, Kristine Stø, Xiang Yi Kong, Tuva B. Dahl, Per H. Nilsson, Peter Libby, Pål Aukrust, Tom Eirik Mollnes, Thor Ueland, Mona Skjelland, Isabel Gonçalves, Bente Halvorsen   +20 more
doaj   +3 more sources

Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement [PDF]

Frontiers in Immunology, 2013
Properdin, the only positive regulatory protein of the complement system, acts as both a stabilizer of the alternative pathway convertases and as a selective pattern recognition molecule of certain microorganisms and host cells (i.e.
Claudio Cortes, Gurpanna Saggu, Viviana P Ferreira   +2 more
exaly   +4 more sources

Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20

Frontiers in Immunology, 2020
Introduction: Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin has shown to bind to heparan sulfate proteoglycans on tubular epithelium and can
Rosa G. M. Lammerts, Ditmer T. Talsma, Wendy A. Dam, Mohamed R. Daha, Marc A. J. Seelen, Stefan P. Berger, Jacob van den Born   +6 more
doaj   +3 more sources

Human Properdin Modulates Macrophage: Mycobacterium bovis BCG Interaction via Thrombospondin Repeats 4 and 5 [PDF]

Frontiers in Immunology, 2018
Mycobacterium tuberculosis can proficiently enter macrophages and diminish complement activation on its cell surface. Within macrophages, the mycobacterium can suppress macrophage apoptosis and survive within the intracellular environment. Previously, we
Maha Ahmed Al-Mozaini, Maha Ahmed Al-Mozaini, Anthony G. Tsolaki, Munirah Abdul-Aziz, Munirah Abdul-Aziz, Suhair M. Abozaid, Suhair M. Abozaid, Mohammed N. Al-Ahdal, Ansar A. Pathan, Valarmathy Murugaiah, Evgeny M. Makarov, Anuvinder Kaur, Robert B. Sim, Uday Kishore, Lubna Kouser   +14 more
doaj   +3 more sources

Differential modulation of SARS-CoV-2 infection by complement factor H and properdin [PDF]

Frontiers in Immunology
IntroductionAn unbalanced immune response and excessive inflammation are the major hallmarks of severe SARS-CoV-2 infection, which can result in multiorgan failure and death. The dysregulation of the complement system has been shown in various studies as
Uday Kishore, Uday Kishore, Praveen M. Varghese, Chandan Kumar, Susan Idicula-Thomas, Martin Mayora Neto, Anthony G. Tsolaki, Pretty Ponnachan, Pretty Ponnachan, Khaled Masmoudi, Basel Al-Ramadi, Basel Al-Ramadi, Manu Vatish, Taruna Madan, Taruna Madan, Nigel Temperton, Nazar Beirag, Nazar Beirag   +17 more
doaj   +4 more sources

Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration [PDF]

mAbs
The bispecific antibody tarperprumig (ALXN1820) was developed as a treatment option for diseases involving dysregulated complement alternative pathway (AP) activity that could be administered in small volumes, either subcutaneously or intravenously ...
Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen, Jeffrey Hunter   +8 more
doaj   +3 more sources

Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans

mBio, 2011
Fungal cell walls are predominantly composed of glucans, mannans, and chitin. Recognition of these glycans by the innate immune system is a critical component of host defenses against the mycoses.
Sarika Agarwal, Charles A. Specht, Haibin Huang, Gary R. Ostroff, Sanjay Ram, Peter A. Rice, Stuart M. Levitz   +6 more
doaj   +2 more sources