Results 1 to 10 of about 8,202 (220)

Infiltrating myeloid cell-derived properdin markedly promotes microglia-mediated neuroinflammation after ischemic stroke [PDF]

Journal of Neuroinflammation, 2023
Background Emerging evidence has shown that myeloid cells that infiltrate into the peri-infarct region may influence the progression of ischemic stroke by interacting with microglia.
Pin-yi Liu, Hui-qin Li, Meng-qi Dong, Xin-ya Gu, Si-yi Xu, Sheng-nan Xia, Xin-yu Bao, Yun Xu, Xiang Cao   +8 more
doaj   +3 more sources

Properdin inhibition ameliorates hepatic ischemia/reperfusion injury without interfering with liver regeneration in mice [PDF]

Frontiers in Immunology, 2023
Hepatic ischemia/reperfusion injury (IRI) often causes serious complications in liver surgeries, including transplantation. Complement activation seems to be involved in hepatic IRI; however, no complement-targeted intervention has been clinically ...
Jiro Kusakabe, Koichiro Hata, Tetsuya Tajima, Hidetaka Miyauchi, Xiangdong Zhao, Shoichi Kageyama, Tatsuaki Tsuruyama, Etsuro Hatano   +7 more
doaj   +3 more sources

Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus Infection [PDF]

Frontiers in Immunology, 2021
The complement system is designed to recognise and eliminate invading pathogens via activation of classical, alternative and lectin pathways. Human properdin stabilises the alternative pathway C3 convertase, resulting in an amplification loop that leads ...
Praveen M. Varghese, Praveen M. Varghese, Shuvechha Mukherjee, Futwan A. Al-Mohanna, Souad M. Saleh, Fahad N. Almajhdi, Nazar Beirag, Saad H. Alkahtani, Reena Rajkumari, Beatrice Nal Rogier, Robert B. Sim, Susan Idicula-Thomas, Taruna Madan, Valarmathy Murugaiah, Uday Kishore   +14 more
doaj   +3 more sources

Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20 [PDF]

Frontiers in Immunology, 2020
Introduction: Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin has shown to bind to heparan sulfate proteoglycans on tubular epithelium and can
Rosa G. M. Lammerts, Ditmer T. Talsma, Wendy A. Dam, Mohamed R. Daha, Marc A. J. Seelen, Stefan P. Berger, Jacob van den Born   +6 more
doaj   +3 more sources

Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway [PDF]

Scientific Reports, 2022
Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz, Yuchen Lin, Joshua Mbroh, Jonas Winkler, Huan Liao, Marie Lackmann, Annemarie Bungartz, Peter F. Zipfel, Christine Skerka, Harald Neumann   +9 more
doaj   +3 more sources

A novel assay that characterizes properdin function shows neutrophil-derived properdin has a distinct oligomeric distribution

Frontiers in Immunology, 2023
Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore, Smrithi S. Menon, Neeti S. Galwankar, Sadik A. Khuder, Michael K. Pangburn, Viviana P. Ferreira   +5 more
doaj   +2 more sources

HBSP improves kidney ischemia-reperfusion injury and promotes repair in properdin deficient mice via enhancing phagocytosis of tubular epithelial cells

Frontiers in Immunology, 2023
Phagocytosis plays vital roles in injury and repair, while its regulation by properdin and innate repair receptor, a heterodimer receptor of erythropoietin receptor (EPOR)/β common receptor (βcR), in renal ischaemia-reperfusion (IR) remains unclear ...
Yuanyuan Wu, Yuanyuan Wu, Lili Huang, Wenli Sai, Fei Chen, Yu Liu, Cheng Han, Joanna M. Barker, Zinah D. Zwaini, Mark P. Lowe, Nigel J. Brunskill, Nigel J. Brunskill, Bin Yang, Bin Yang   +13 more
doaj   +2 more sources

Properdin Deficiency Impairs Phagocytosis and Enhances Injury at Kidney Repair Phase Post Ischemia–Reperfusion

Frontiers in Immunology, 2021
Properdin, a positive regulator of complement alternative pathway, participates in renal ischemia–reperfusion (IR) injury and also acts as a pattern-recognition molecule affecting apoptotic T-cell clearance.
Yuanyuan Wu, Yuanyuan Wu, Zinah D. Zwaini, Nigel J. Brunskill, Nigel J. Brunskill, Xinyue Zhang, Hui Wang, Ravinder Chana, Cordula M. Stover, Bin Yang, Bin Yang   +10 more
doaj   +2 more sources

Prognostic Value of Complement Properdin in Cancer

Frontiers in Immunology, 2021
The complement system is readily triggered by the presence of damage-associated molecular patterns on the surface of tumor cells. The complement alternative pathway provides rapid amplification of the molecular stress signal, leading to complement ...
Alessandro Mangogna, Praveen M. Varghese, Praveen M. Varghese, Chiara Agostinis, Salman H. Alrokayan, Haseeb A. Khan, Cordula M. Stover, Beatrice Belmonte, Anna Martorana, Giuseppe Ricci, Giuseppe Ricci, Roberta Bulla, Uday Kishore   +12 more
doaj   +2 more sources

Structure and function of a family of tick-derived complement inhibitors targeting properdin

Nature Communications, 2022
Properdin is the only known positive regulator of the human complement system, stabilising the convertase C3 in the alternative pathway of complement activation.
Katharina Braunger, Jiyoon Ahn, Matthijs M. Jore, Steven Johnson, Terence T. L. Tang, Dennis V. Pedersen, Gregers R. Andersen, Susan M. Lea   +7 more
doaj   +2 more sources