Results 71 to 80 of about 5,197 (155)

Lipid Mediator Metabolomics Via LC-MS/MS Profiling and Analysis. [PDF]

, 2018
protocolSolid-phase extraction coupled with liquid chromatography tandem mass spectrometry provides a robust and sensitive approach for the identification and quantitation of specialized pro-resolving mediators (lipoxins, resolvins, protectins, and ...
Dalli, J, Serhan, CN, Walker, ME, Mary E. Walker, Jesmond Dalli, Romain A. Colas, Charles N. Serhan, Colas, RA   +7 more
core   +1 more source

Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis

Frontiers in Pharmacology, 2019
Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease.
Antonio Recchiuti, Antonio Recchiuti, Domenico Mattoscio, Domenico Mattoscio, Elisa Isopi, Elisa Isopi   +5 more
doaj   +1 more source

Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase[S]

Journal of Lipid Research, 2013
Resolvins and protectins are important anti-inflammatory and pro-resolution compounds derived from the enzymatic oxidation of omega-3 fatty acids all-cis-5,8,11,14,17-eicosapentaenoic acid (EPA) and all-cis-4,7,10,13,16,19-docosahexaenoic acid (DHA).
Eleanor P. Dobson, Colin J. Barrow, Jaroslav A. Kralovec, Jacqui L. Adcock   +3 more
doaj   +1 more source

Long chain polyunsaturated fatty acids : selected mechanisms of action on bone [PDF]

, 2010
Evidence presented over the past 20 years has shown that long-chain polyunsaturated fatty acids (LCPUFAs), especially the n-3 fatty acids such as eicospentaenoic acid (EPA) and docosahexaenoic acid (DHA) are beneficial for bone health.
M.C. Kruger, Coetzee, Magdalena, Kruger, Marlena C., Haag, Marianne, M. Coetzee, H. Weiler, M. Haag, Weiler, H.   +7 more
core   +1 more source

Pro-Resolving Lipid Mediators in the Pathophysiology of Asthma

Medicina, 2019
Asthma is one of the most important medical and social problems of our time due to the prevalence and the complexity of its treatment. Chronic inflammation that is characteristic of asthma is accompanied by bronchial obstruction, which involves various ...
Oxana Kytikova, Tatyana Novgorodtseva, Yulia Denisenko, Marina Antonyuk, Tatyana Gvozdenko   +4 more
doaj   +1 more source

Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases

Mediators of Inflammation, 2018
Acute inflammatory responses are host-protective and normally self-limited; these responses can maintain cell homeostasis and promote defense against various infections and damage factors.
Shi Tang, Ming Wan, Wei Huang, R. C. Stanton, Yong Xu   +4 more
doaj   +1 more source

Docosahexanoic acid (DHA) reduces brain damage induced by reversible middle cerebral artery occlusion (MCAO) in mice

Zagazig Journal of Pharmaceutical Sciences, 2013
Stroke is a leading cause of death and permanent disability in adults worldwide. The only FDA-approved treatment for acute ischemic stroke is the intravenous recombinant tissue plasminogen activator (rt-PA) within 3 hours of onset Among the mechanisms ...
Waleed Barakat , Mohamed Mahrous , Mohamed Zakaria   +2 more
doaj   +1 more source

Low-dose pro-resolving mediators temporally reset the resolution response to microbial inflammation

Molecular Medicine
Background Specialized pro-resolving mediators (SPMs) promote resolution of inflammation, clear infections and stimulate tissue regeneration. These include resolvins, protectins, and maresins.
Charles N. Serhan, Nan Chiang, Robert Nshimiyimana   +2 more
doaj   +1 more source

Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative review

Frontiers in Immunology
Sepsis is a life-threatening syndrome of organ dysfunction, characterized by uncontrolled inflammatory response and immune dysregulation, often leading to multiple organ failure and even death.
Shujun Sun, Shujun Sun, Shujun Sun, Shujun Sun, Dong Yang, Dong Yang, Dong Yang, Jing Lv, Jing Lv, Jing Lv, Haifa Xia, Haifa Xia, Haifa Xia, Zhangyan Mao, Zhangyan Mao, Zhangyan Mao, Zhangyan Mao, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen, Yafen Gao, Yafen Gao, Yafen Gao   +22 more
doaj   +1 more source

Uncovering the Power of GPR18 Signalling: How RvD2 and Other Ligands Could Have the Potential to Modulate and Resolve Inflammation in Various Health Disorders

Molecules
The resolution of inflammation is the primary domain of specialised pro-resolving mediators (SPMs), which include resolvins, protectins, and their forms synthesised under the influence of aspirin and the maresins.
Ewelina Honkisz-Orzechowska, Dorota Łażewska, Grzegorz Baran, Katarzyna Kieć-Kononowicz   +3 more
doaj   +1 more source