Results 11 to 20 of about 1,905,470 (305)
METTL3 regulates WTAP protein homeostasis [PDF]
Cell Death & Disease, 2018 The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Capuano, Ernestina +8 more
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Altered Mitochondrial Protein Homeostasis and Proteinopathies
Frontiers in Molecular Neuroscience, 2022 Increasing evidence implicates mitochondrial dysfunction as key in the development and progression of various forms of neurodegeneration. The multitude of functions carried out by mitochondria necessitates a tight regulation of protein import, dynamics ...
Aya Jishi, Xin Qi
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CRYPTOCHROMES promote daily protein homeostasis [PDF]
The EMBO Journal, 2021 The daily organisation of most mammalian cellular functions is attributed to circadian regulation of clock-controlled protein expression, driven by daily cycles of CRYPTOCHROME-dependent transcriptional feedback repression. To test this, we used quantitative mass spectrometry to compare wild-type and CRY-deficient fibroblasts under constant conditions.
Wong, David CS +12 more
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Organismal Protein Homeostasis Mechanisms [PDF]
Genetics, 2020 Abstract Sustaining a healthy proteome is a lifelong challenge for each individual cell of an organism. However, protein homeostasis or proteostasis is constantly jeopardized since damaged proteins accumulate under proteotoxic stress that originates from ever-changing metabolic, environmental, and pathological conditions. Proteostasis is
Hoppe, Thorsten, Cohen, Ehud
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Sorting Nexins in Protein Homeostasis [PDF]
Cells, 2020 Sorting nexins (SNXs) are a highly conserved membrane-associated protein family that plays a role in regulating protein homeostasis. This family of proteins is unified by their characteristic phox (PX) phosphoinositides binding domain. Along with binding to membranes, this family of SNXs also comprises a diverse array of protein-protein interaction ...
Cooper, Katrina F., Hanley, Sarah E.
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Mitochondrial protein homeostasis [PDF]
IUBMB Life, 2013 AbstractMitochondria use 800–1,500 proteins to perform their biological functions in the eukaryotic cells. Distinct transport and sorting mechanisms are responsible for the delivery of proteins to the correct location within mitochondria. Mitochondrial proteins undergo processing events and form functional assemblies.
Aksana, Varabyova +2 more
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Research progress of integrated stress response in pathogenesis of Alzheimer's disease
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Integrated stress response (ISR) is a cellular adaptive response induced by stress, which is strictly regulated by multiple phosphokinases, phosphatases and other proteins to maintain protein homeostasis.
SUN Hui +6 more
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Protein homeostasis imprinting across evolution [PDF]
NAR Genomics and Bioinformatics, 2020 Abstract Protein homeostasis (a.k.a. proteostasis) is associated with the primary functions of life, and therefore with evolution. However, it is unclear how cellular proteostasis machines have evolved to adjust protein biogenesis needs to environmental constraints. Herein, we describe a novel computational approach, based on semantic
Koutsandreas, Thodoris +3 more
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On the Role of the Immunoproteasome in Protein Homeostasis
Cells, 2021 Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
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Actin dynamics in protein homeostasis
Bioscience Reports, 2022 Abstract Cell homeostasis is maintained in all organisms by the constant adjustment of cell constituents and organisation to account for environmental context. Fine-tuning of the optimal balance of proteins for the conditions, or protein homeostasis, is critical to maintaining cell homeostasis.
Thomas D. Williams, Adrien Rousseau
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