Results 11 to 20 of about 1,466,359 (163)
Circadian Reprogramming of Protein Homeostasis and Glycolipid Metabolism in Diabetic Nephropathy [PDF]
FASEB BioAdvancesDysfunction of the circadian clock has been implicated in the pathogenesis of various diseases, including metabolic disorders, inflammatory conditions, and cancer.
Xiao‐Qian Li +8 more
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Altered Mitochondrial Protein Homeostasis and Proteinopathies
Frontiers in Molecular Neuroscience, 2022 Increasing evidence implicates mitochondrial dysfunction as key in the development and progression of various forms of neurodegeneration. The multitude of functions carried out by mitochondria necessitates a tight regulation of protein import, dynamics ...
Aya Jishi, Xin Qi
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Single-cell expression predicts neuron-specific protein homeostasis networks [PDF]
Open BiologyThe protein homeostasis network keeps proteins in their correct shapes and avoids unwanted aggregation. In turn, the accumulation of aberrantly misfolded proteins has been directly associated with the onset of ageing-associated neurodegenerative diseases
Sebastian Pechmann
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pSTAT3 transactivates EGFR in maintaining EGFR protein homeostasis and EGFR-TKI resistance [PDF]
Acta Biochimica et Biophysica SinicaEGFR protein trafficking is critical for regulating multiple biological processes, including cell growth and survival. However, how EGFR protein homeostasis is maintained remains unclear.
Ao Juan +10 more
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CRYPTOCHROMES promote daily protein homeostasis [PDF]
The EMBO Journal, 2021 The daily organisation of most mammalian cellular functions is attributed to circadian regulation of clock-controlled protein expression, driven by daily cycles of CRYPTOCHROME-dependent transcriptional feedback repression. To test this, we used quantitative mass spectrometry to compare wild-type and CRY-deficient fibroblasts under constant conditions.
Wong, David CS +12 more
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Organismal Protein Homeostasis Mechanisms [PDF]
Genetics, 2020 Abstract Sustaining a healthy proteome is a lifelong challenge for each individual cell of an organism. However, protein homeostasis or proteostasis is constantly jeopardized since damaged proteins accumulate under proteotoxic stress that originates from ever-changing metabolic, environmental, and pathological conditions. Proteostasis is
Hoppe, Thorsten, Cohen, Ehud
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Sorting Nexins in Protein Homeostasis [PDF]
Cells, 2020 Sorting nexins (SNXs) are a highly conserved membrane-associated protein family that plays a role in regulating protein homeostasis. This family of proteins is unified by their characteristic phox (PX) phosphoinositides binding domain. Along with binding to membranes, this family of SNXs also comprises a diverse array of protein-protein interaction ...
Cooper, Katrina F., Hanley, Sarah E.
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Cells, 2022 Ribosomes within a cell are commonly viewed as biochemically homogenous RNA–protein super-complexes performing identical functions of protein synthesis.
Wenzhu Li +6 more
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Mitochondrial protein homeostasis [PDF]
IUBMB Life, 2013 AbstractMitochondria use 800–1,500 proteins to perform their biological functions in the eukaryotic cells. Distinct transport and sorting mechanisms are responsible for the delivery of proteins to the correct location within mitochondria. Mitochondrial proteins undergo processing events and form functional assemblies.
Aksana, Varabyova +2 more
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Targeting of client proteins to the VCP/p97/Cdc48 unfolding machine
Frontiers in Molecular Biosciences, 2023 The AAA+ ATPase p97 (also called VCP or Cdc48) is a major protein unfolding machine with hundreds of clients in diverse cellular pathways that are critical for cell homeostasis, proliferation and signaling. In this review, we summarize recent advances in
Hemmo Meyer, Johannes van den Boom
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