Results 21 to 30 of about 1,905,470 (305)
Potential roles for mitochondria-to-HSF1 signaling in health and disease
Frontiers in Molecular Biosciences, 2023 The ability to respond rapidly and efficiently to protein misfolding is crucial for development, reproduction and long-term health. Cells respond to imbalances in cytosolic/nuclear protein homeostasis through the Heat Shock Response, a tightly regulated ...
Johnathan Labbadia
doaj +1 more source
Mitochondrial Protein Homeostasis and Cardiomyopathy
International Journal of Molecular Sciences, 2022 Human mitochondrial disorders impact tissues with high energetic demands and can be associated with cardiac muscle disease (cardiomyopathy) and early mortality. However, the mechanistic link between mitochondrial disease and the development of cardiomyopathy is frequently unclear.
Emily Wachoski-Dark +4 more
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Mitochondrial Impairment in Sarcopenia
Biology, 2021 Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered
Francesco Bellanti +2 more
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Protein synthesis controls phosphate homeostasis [PDF]
Genes & Development, 2018 Phosphorus is an essential element assimilated largely as orthophosphate (Pi). Cells respond to Pi starvation by importing Pi from their surroundings. We now report that impaired protein synthesis alone triggers a Pi starvation response even when Pi is plentiful in the extracellular milieu.
Pontes, Mauricio H. +1 more
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Protein homeostasis and synaptic plasticity [PDF]
The EMBO Journal, 2010 It is clear that de novo protein synthesis has an important function in synaptic transmission and plasticity. A substantial amount of work has shown that mRNA translation in the hippocampus is spatially controlled and that dendritic protein synthesis is required for different forms of long-term synaptic plasticity.
Cajigas, I., Will, T., Schuman, E.
openaire +3 more sources
Protein homeostasis in aging and cancer. [PDF]
Front Cell Dev Biol, 2023 Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can improve health and quality of life for older individuals ...
Chen XQ +5 more
europepmc +4 more sources
Frontiers in Molecular Neuroscience, 2023 Spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease, is the most common dominantly inherited ataxia. SCA3 is caused by a CAG repeat expansion in the ATXN3 gene that encodes an expanded tract of polyglutamine in the disease protein ...
Haiyang Luo +5 more
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Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control [PDF]
, 2018 The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological ...
Abeti +66 more
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Strategies targeting endoplasmic reticulum stress to improve Parkinson’s disease
Frontiers in Pharmacology, 2023 Parkinson’s disease (PD) is a common neurodegenerative disorder with motor symptoms, which is caused by the progressive death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc).
Danni Wang +6 more
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Anchored phosphatases modulate glucose homeostasis. [PDF]
, 2012 Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways.
Cirulli, Vincenzo +12 more
core +1 more source