Results 31 to 40 of about 1,466,359 (163)
Mitochondrial Impairment in Sarcopenia
Biology, 2021 Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered
Francesco Bellanti +2 more
doaj +1 more source
Protein synthesis controls phosphate homeostasis [PDF]
Genes & Development, 2018 Phosphorus is an essential element assimilated largely as orthophosphate (Pi). Cells respond to Pi starvation by importing Pi from their surroundings. We now report that impaired protein synthesis alone triggers a Pi starvation response even when Pi is plentiful in the extracellular milieu.
Pontes, Mauricio H. +1 more
openaire +2 more sources
Protein homeostasis and synaptic plasticity [PDF]
The EMBO Journal, 2010 It is clear that de novo protein synthesis has an important function in synaptic transmission and plasticity. A substantial amount of work has shown that mRNA translation in the hippocampus is spatially controlled and that dendritic protein synthesis is required for different forms of long-term synaptic plasticity.
Cajigas, I., Will, T., Schuman, E.
openaire +3 more sources
Frontiers in Molecular Neuroscience, 2023 Spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease, is the most common dominantly inherited ataxia. SCA3 is caused by a CAG repeat expansion in the ATXN3 gene that encodes an expanded tract of polyglutamine in the disease protein ...
Haiyang Luo +5 more
doaj +1 more source
Strategies targeting endoplasmic reticulum stress to improve Parkinson’s disease
Frontiers in Pharmacology, 2023 Parkinson’s disease (PD) is a common neurodegenerative disorder with motor symptoms, which is caused by the progressive death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc).
Danni Wang +6 more
doaj +1 more source
METTL3 regulates WTAP protein homeostasis [PDF]
Cell Death & Disease, 2018 AbstractThe Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Sorci, Melissa +8 more
openaire +3 more sources
Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease
Frontiers in Cell and Developmental Biology, 2021 Ubiquitination is a posttranslational modification of proteins that significantly affects protein stability and function. The specificity of substrate recognition is determined by ubiquitin E3 ligase during ubiquitination.
Lidong Wang +3 more
doaj +1 more source
eLife, 2022 The biogenesis of eukaryotic ribosomes involves the ordered assembly of around 80 ribosomal proteins. Supplying equimolar amounts of assembly-competent ribosomal proteins is complicated by their aggregation propensity and the spatial separation of their ...
Benjamin Pillet +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 For fully differentiated, long lived cells the maintenance of protein homeostasis (proteostasis) becomes a crucial determinant of cellular function and viability.
Shenae L. Cafe +7 more
doaj +1 more source
Protein homeostasis imprinting across evolution. [PDF]
NAR Genom Bioinform, 2020 Abstract Protein homeostasis (a.k.a. proteostasis) is associated with the primary functions of life, and therefore with evolution. However, it is unclear how cellular proteostasis machines have evolved to adjust protein biogenesis needs to environmental constraints. Herein, we describe a novel computational approach, based on semantic
Koutsandreas T +3 more
europepmc +4 more sources