Results 11 to 20 of about 746,971 (308)

Protein translocation across mitochondrial membranes [PDF]

BioEssays, 1992
Protein translocation across biological membranes is of fundamental importance for the biogenesis of organelles and in protein secretion. We will give an overview of the recent achievements in the understanding of protein translocation across ...
Arretz, Attardi, Baker, Becker, Behrens, Chen, Cheng, Chirico, Deshaies, Drygas, Dumont, Dumont, Eilers, Ellis, Hartl, Hartl, Hartl, Hawlitschek, Hines, Kang, Kellems, Kiebler, Koll, Kusakawa, Mahlke, Murakami, Murakami, Murakami, Neupert, Nicholson, Ono, Ostermann, Ostermann, Ou, Pain, Pelham, Pfaller, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pollock, Pon, Rassow, Rassow, Reading, Rietveld, Rothman, Scherer, Schleyer, Schneider, Schulte, Schwaiger, Steger, Stuart, Söllner, Söllner, Söllner, Vestweber, Vestweber, Wienhues, Witte   +62 more
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The Translocator Protein [PDF]

Journal of Nuclear Medicine, 2011
The translocator protein (TSPO) is expressed at low levels in the healthy human brain and is markedly upregulated in response to brain injury and inflammation. This increase in TSPO expression is correlated to the extent of microglial activation, making the measurement of TSPO density a useful indicator of active brain disease.
Alana M, Scarf, Michael, Kassiou
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Protein Translocation: Tunnel Vision [PDF]

Cell, 1998
We apologize to colleagues whose important work could only be covered by reference to reviews and discussions in other papers. We thank M. Rolls, C. Shamu, W. Prinz, and P. Silver for valuable comments on the manuscript. After completion of this manuscript we became aware of a recent review by R. S. Hegde and V. R. Lingappa (Cell 91, 575–582), to which
Matlack, Kent E.S, Mothes, Walther, Rapoport, Tom A   +2 more
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Functional Organization of Sequence Motifs in Diverse Transit Peptides of Chloroplast Proteins

Frontiers in Physiology, 2021
Although the chloroplasts in plants are characterized by an inherent genome, the chloroplast proteome is composed of proteins encoded by not only the chloroplast genome but also the nuclear genome.
Jinseung Jeong, Inhwan Hwang, Dong Wook Lee, Dong Wook Lee   +3 more
doaj   +1 more source

Translocator protein and steroidogenesis [PDF]

Biochemical Journal, 2018
Two interesting papers by Barren et al. and Owen et al. have been very recently published in Biochemical Journal, reporting the role of translocator protein (TSPO) in steroidogenesis. The involvement of TSPO in the steroid biosynthesis has been suggested by 30 years of researches, using biochemical, pharmacological and genetic experimental approaches ...
Costa, Barbara, Pozzo, Eleonora Da, Martini, Claudia   +2 more
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YidC from Escherichia coli Forms an Ion-Conducting Pore upon Activation by Ribosomes

Biomolecules, 2023
The universally conserved protein YidC aids in the insertion and folding of transmembrane polypeptides. Supposedly, a charged arginine faces its hydrophobic lipid core, facilitating polypeptide sliding along YidC’s surface.
Denis G. Knyazev, Lukas Winter, Andreas Vogt, Sandra Posch, Yavuz Öztürk, Christine Siligan, Nikolaus Goessweiner-Mohr, Nora Hagleitner-Ertugrul, Hans-Georg Koch, Peter Pohl   +9 more
doaj   +1 more source

Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion

eLife, 2022
Transport of proteins across and into membranes is a fundamental biological process with the vast majority being conducted by the ubiquitous Sec machinery.
William J Allen, Robin A Corey, Daniel W Watkins, A Sofia F Oliveira, Kiel Hards, Gregory M Cook, Ian Collinson   +6 more
doaj   +1 more source

Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex [PDF]

, 2012
The bacterial ATPase SecA and protein channel complex SecYEG form the core of an essential protein translocation machinery. The nature of the conformational changes induced by each stage of the hydrolytic cycle of ATP and how they are coupled to protein ...
Alice Robson, Bauer, Berger, Bessonneau, Breyton, Brundage, Cannon, Dalal, Deville, Ding, Duong, Egea, Erlandson, Erlandson, Gelis, Gold, Gold, Gold, Hizlan, Hunt, Ian Collinson, Karamanou, Lill, Or, Osborne, Osborne, Park, Park, Piggot, Piggot, Richard B. Sessions, Robson, Robson, Robson, Sarah Whitehouse, Tam, Van den Berg, Vicki A.M. Gold, William J. Allen, Wolf, Woodbury, Zimmer, Zimmer   +42 more
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Peroxisomal protein translocation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010
Peroxisomes perform a wide variety of metabolic processes in eukaryotic organisms. Mutations that affect peroxisome function or formation have profound phenotypic consequences, the latter demonstrated by peroxisome biogenesis disorders which are often fatal.
Girzalsky, Wolfgang, Saffian, Delia, Erdmann, Ralf   +2 more
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Persistent systemic microbial translocation, inflammation, and intestinal damage during Clostridioides difficile infection [PDF]

, 2020
Background. Clostridioides difficile infection (CDI) might be complicated by the development of nosocomial bloodstream infection (n-BSI). Based on the hypothesis that alteration of the normal gut integrity is present during CDI, we evaluated markers of ...
Aversano, L., Battaglia, R., Bruno, G., Ciardi, M. R., Corazziari, E. S., de Angelis, M., Iera, J., Mascellino, M. T., Mastroianni, C. M., Miele, M. C., Morelli, S., Oliva, A., Venditti, M., Vullo, V.   +13 more
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