Results 21 to 30 of about 746,971 (308)
Frontiers in Immunology, 2022 Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic.
Belinda S. Hall +3 more
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Reconstitution of bacterial autotransporter assembly using purified components
eLife, 2014 Autotransporters are a superfamily of bacterial virulence factors consisting of an N-terminal extracellular (‘passenger’) domain and a C-terminal β barrel (‘β’) domain that resides in the outer membrane (OM).
Giselle Roman-Hernandez +2 more
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The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity
eLife, 2019 In bacteria, the translocation of proteins across the cytoplasmic membrane by the Sec machinery requires the ATPase SecA. SecA binds ribosomes and recognises nascent substrate proteins, but the molecular mechanism of nascent substrate recognition is ...
Mohammed Jamshad +10 more
doaj +1 more source
The gateway to chloroplast: re-defining the function of chloroplast receptor proteins [PDF]
, 2012 Chloroplast biogenesis often requires a tight orchestration between gene expression (both plastidial and nuclear) and translocation of similar to 3000 nuclear-encoded proteins into the organelle.
Bölter, Bettina +2 more
core +1 more source
Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation [PDF]
, 2017 The relationship between protein synthesis, folding and disulfide formation within the endoplasmic reticulum (ER) is poorly understood. Previous studies have suggested pre-existing disulfide links are absolutely required to allow protein folding and ...
Bulleid, Neil J. +3 more
core +1 more source
The Tat-dependent protein translocation pathway
Biomolecular Concepts, 2011 The twin-arginine translocation (Tat) pathway is found in bacteria, archaea, and plant chloroplasts, where it is dedicated to the transmembrane transport of fully folded proteins.
Hou Bo, Brüser Thomas
doaj +1 more source
mBio, 2021 Bacterial type IV secretion systems (T4SSs) mediate the conjugative transfer of mobile genetic elements (MGEs) and their cargoes of antibiotic resistance and virulence genes.
Abu Amar M. Al Mamun +2 more
doaj +1 more source
Protein folding causes an arrest of preprotein translocation into mitochondria in vivo [PDF]
, 1991 With vital yeast cells, a hybrid protein consisting of the amino- terminal third of the precursor to cytochrome b2 and of the entire dihydrofolate reductase was arrested on the import pathway into mitochondria.
Becker, Karin +7 more
core +3 more sources
Proton Translocation in Proteins
Annual Review of Physical Chemistry, 1989 The active transport of protons across the low dielectric barrier imposed by biological membranes is accomplished by a plethora of proteins that span the ca. 40 A of the phospholipid bilayer. The free energy derived from the proton electrochemical potential established by the translocation of these protons can subsequently be used to drive vital ...
Copeland, Robert A., Chan, Sunney I.
openaire +3 more sources
eLife, 2017 Proteins destined for the mitochondrial matrix are targeted to the inner membrane Tim17/23 translocon by their presequences. Inward movement is driven by the matrix-localized, Hsp70-based motor. The scaffold Tim44, interacting with the matrix face of the
See-Yeun Ting +3 more
doaj +1 more source