Results 31 to 40 of about 746,971 (308)

Mitochondrial precursor proteins are imported through a hydrophilic membrane environment [PDF]

, 1987
We have analyzed how translocation intermediates of imported mitochondrial precursor proteins, which span contact sites, interact with the mitochondrial membranes.
Anderson D., Argan C., Bohni P. C., Daum G., Evans E. A., Gasser S. M., Gilmore R., Guiard B., Hartl F.-U., Hennig B., Hennig B., Hortsch M., Hortsch M., Kaput J., Laemmli U. K., McAda P. C., Miura S., Nicholls D. G., Pelham H. R. B., Pfaller R., Pfaller R., Pfanner N., Pfanner N., Pfanner N., Pfanner N., Pfanner N., Pratje E., Riezman H., Sadler I., Schleyer M., Schleyer M., Schmidt B., Schwaiger M., Steck T. L., Stueber D., Wikstrom M., Zwizinski C., Zwizinski C., Zwizinski C.   +38 more
core   +1 more source

Protein translocation across membranes

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2001
Cellular membranes act as semipermeable barriers to ions and macromolecules. Specialized mechanisms of transport of proteins across membranes have been developed during evolution. There are common mechanistic themes among protein translocation systems in bacteria and in eukaryotic cells.
Agarraberes, Fernando A, Dice, J.Fred
openaire   +2 more sources

Translocator Protein (TSPO) [PDF]

, 2018
The high number of papers submitted and ultimately accepted for publication in this special issue attests the great amount of research being conducted on TSPO and its role in living cells. Thus, TSPO has become an extremely attractive subcellular biomark for the early detection of disease states overexpressing this protein and for the selective ...
Nunzio Denora (Ed.), Giovanni Natile (Ed.)   +1 more
openaire   +3 more sources

Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

eLife, 2016
The essential process of protein secretion is achieved by the ubiquitous Sec machinery. In prokaryotes, the drive for translocation comes from ATP hydrolysis by the cytosolic motor-protein SecA, in concert with the proton motive force (PMF). However, the
William John Allen, Robin Adam Corey, Peter Oatley, Richard Barry Sessions, Steve A Baldwin, Sheena E Radford, Roman Tuma, Ian Collinson   +7 more
doaj   +1 more source

Protein Translocation into Mitochondria

Neurosignals, 2001
The biogenesis of mitochondria requires the translocation of most mitochondrial proteins across two biological membranes. Mitochondrial preproteins are synthesized in the cytosol carrying targeting information, that is recognized by specific receptor proteins.
Schmidt, Sigune, Strub, Andreas, Voos, Wolfgang   +2 more
openaire   +3 more sources

Membrane translocation of folded proteins

Journal of Biological Chemistry, 2022
An ever-increasing number of proteins have been shown to translocate across various membranes of bacterial as well as eukaryotic cells in their folded states as a part of physiological and/or pathophysiological processes. Herein, we provide an overview of the systems/processes that are established or likely to involve the membrane translocation of ...
Pei, Dehua, Dalbey, Ross E.
openaire   +2 more sources

Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]

, 2005
The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC, Brown, DA, Filippov, AK, Hughes, S, Marsh, SJ, Tatulian, L, Winks, JS   +6 more
core   +1 more source

Channel-Forming Bacterial Toxins in Biosensing and Macromolecule Delivery

Toxins, 2014
To intoxicate cells, pore-forming bacterial toxins are evolved to allow for the transmembrane traffic of different substrates, ranging from small inorganic ions to cell-specific polypeptides. Recent developments in single-channel electrical recordings,
Philip A. Gurnev, Ekaterina M. Nestorovich   +1 more
doaj   +1 more source

Hsp70 in mitochondrial biogenesis [PDF]

, 1994
The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non ...
A. Tzagoloff, A. Tzagoloff, A.J. Caplan, A.J. Caplan, B.D. Gambill, B.S. Glick, C.K. Suzuki, D. Ang, D. M. Cyr, D.M. Cyr, D.M. Cyr, D.M. Cyr, D.M. Cyr, D.P. Atencio, E. Ikeda, E. Kutejová, E.A. Craig, E.A. Craig, F.-U. Hartl, G.S.P. Groot, H.R.B. Pelham, J. Ostermann, J. Rassow, J.F. Dice, J.P. Hendrick, K. Liberek, L. Dyck van, M. Eilers, M. Kiebler, M. Schleyer, M.-J. Gething, M.Y. Cheng, N. Rowley, N. Wang, P. Borst, P. Terpstra, P.-J. Kang, R. A. Stuart, R.A. Stuart, R.A. Stuart, R.B. Deshaies, R.G. Hadikusumo, R.J. Nelson, R.P. Beckman, S. Lindquist, S. Rospert, S.T. Hwang, T. Langer, U.C. Manning-Krieg, W. Neupert, W. Neupert, W. Voos, W.J. Chirico, Z. Xia   +53 more
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Characterization of the protein import apparatus in isolated outer envelopes of chloroplasts [PDF]

, 1991
Isolated outer envelope membrane from pea (Pisum sativum L.) chloroplasts can be used in vitro to study binding and partial translocation of precursor proteins destined for the inside of the organelle.
Ansorge, Arnon, Baker, Bonner, Cline, Cornwall, Douce, Flügge, Flügge, Harlow, Hartl, Hartl, Heijne, Hinz, Joyard, Kaderbhai, Kang, Keegstra, Keegstra, Kiebler, Laemmli, Lowry, Lubben, Marshall, Neumann, Olsen, Pain, Pfanner, Robinson, Salomon, Scherer, Schindler, Schnell, Theg, Towbin, Waegemann, Wiedmann   +36 more
core   +1 more source