Results 1 to 10 of about 5,276 (193)

Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma [PDF]

Communications Biology
Serine is essential to maintain maximal growth and proliferation of cancer cells by providing adequate intermediate metabolites and energy. Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis.

exaly   +5 more sources

Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant

Signal Transduction and Targeted Therapy, 2023
The single-nucleotide polymorphism (SNP) of p53, in particular the codon 72 variants, has recently been implicated as a critical regulator in tumor progression. However, the underlying mechanism remains elusive.
Hai-Ning Chen, Edouard C Nice, Canhua Huang   +2 more
exaly   +4 more sources

Downregulation of PSAT1 inhibits cell proliferation and migration in uterine corpus endometrial carcinoma

Scientific Reports, 2023
Phosphoserine aminotransferase 1 (PSAT1) has been associated with the occurrence and development of various carcinomas; however, its function in uterine corpus endometrial carcinoma (UCEC) is unknown.
Min Wang, Song Yue, Zhu Yang
exaly   +4 more sources

Bioinformatics‐based discovery of the involvement of PSAT1 in mediating the anti‐lung adenocarcinoma activity of triptolide [PDF]

Animal Models and Experimental Medicine
Background Triptolide (TP) exhibits various pharmacological activities. Our previous studies have confirmed the efficacy of TP against lung adenocarcinoma (LUAD). However, the potent pharmacological activity of TP is underpinned by its complex mechanisms.
Zhiwen Cao, Lulu Zhang, Wenqiang Zhang, Rong Wan, Xiaogang Peng, Jinyan Xie, Ruru Bai, Jiejing Jin, Changqi Shi, Lan Yan, Xiangyu Guo, Yang Shen, Cheng Lu   +12 more
doaj   +3 more sources

An integrated pan-cancer analysis of PSAT1: A potential biomarker for survival and immunotherapy

Frontiers in Genetics, 2022
Phosphoserine aminotransferase 1 (PSAT1) may be an oncogene that plays an important role in various cancer types. However, there are still many gaps in the expression of PSAT1 gene and its biological impact in different types of tumors.
Mingtao Feng, Huanhuan Cui, Wenjing Tu, Liangdong Li, Yang Gao, Lei Chen, Deheng Li, Xin Chen, Fengfeng Xu, Changshuai Zhou, Yiqun Cao   +10 more
exaly   +5 more sources

PSAT1 inhibits ferroptosis in osteosarcoma cells by activating the Xct/GPX4 signaling axis [PDF]

Scientific Reports
Osteosarcoma is a prevalent primary malignant bone tumor predominantly affecting children and adolescents, characterized by a poor survival rate and prognosis. Currently, ferroptosis is a newly defined form of cell death, but the mechanism between it and
Po Wang, Jun Xiao, Jin Zeng, Feng Yang, Mingchao Lin, Tao Liang, Hucheng Liu, Haibo Zhan   +7 more
doaj   +3 more sources

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer [PDF]

Scientific Reports, 2017
In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to tamoxifen treatment in recurrent disease.
Tommaso De Marchi, Mieke A. Timmermans, Anieta M. Sieuwerts, Marcel Smid, Maxime P. Look, Nicolai Grebenchtchikov, Fred C. G. J. Sweep, Jan G. Smits, Viktor Magdolen, Carolien H. M. van Deurzen, John A. Foekens, Arzu Umar, John W. Martens   +12 more
doaj   +2 more sources

Stabilization of Notch1 and β-catenin in response to ER- breast cancer-specific up-regulation of PSAT1 mediates distant metastasis

Translational Oncology, 2022
Breast cancer has the highest incidence in women worldwide, with a mortality rate second only to lung cancer. Distant metastasis is the major cause of breast cancer-induced death.
Lei Liu
exaly   +3 more sources

Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis [PDF]

Molecular Metabolism
Dietary sulfur amino acid restriction (SAAR) improves whole-body glucose homeostasis, elevates liver insulin action, and lowers liver triglycerides. These adaptations are associated with an increased expression of hepatic de novo serine synthesis enzymes,
Andres F. Ortega, Cha Mee Vang, Ferrol I. Rome, Kaitlyn M. Andreoni, Aiden M. Phoebe, Alisa B. Nelson, Peter A. Crawford, James J. Galligan, Stanley Ching-Cheng Huang, Curtis C. Hughey   +9 more
doaj   +2 more sources

Histone lactylation-boosted AURKB facilitates colorectal cancer progression by inhibiting HNRNPM-mediated PSAT1 mRNA degradation [PDF]

Journal of Experimental & Clinical Cancer Research
Background Aurora kinase B (AURKB), a key regulator of mitosis, is frequently upregulated in various malignancies, including colorectal cancer (CRC), and is associated with poor prognosis.
Yuyi Li, Jinjin Peng, Di Wu, Qingxin Xie, Yichao Hou, Linjing Li, Xintian Zhang, Yu Liang, Jing Feng, Jiaqing Chen, Wangshuang Chen, Che Xu, Han Yao, Xiangjun Meng   +13 more
doaj   +2 more sources