Results 101 to 110 of about 5,276 (193)

Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins [PDF]

, 2008
We report an advanced chemoenzymatic strategy for the direct fluorescence detection, proteomic analysis, and cellular imaging of O-GlcNAc-modified proteins.
Agnew, Brian J., Buck, Suzanne B., Clark, Peter M., Dweck, Jessica F., Hart, Courtenay R., Hsieh-Wilson, Linda C., Mason, Daniel E., Peters, Eric C.   +7 more
core   +1 more source

Abstract 2845: The role of PSAT1 in triple negative breast cancer metastasis

Cancer Research, 2019
Abstract Breast cancer is the number one diagnosed cancer type among women in the United States (NCI). This disease can be stratified into different molecular subtypes, including triple negative breast cancer (TNBC), each of which can have different therapeutic options, patient prognosis, and survival outcomes.
Stephanie Metcalf, Traci Kruer, Susan Dougherty, Rumeysa Biyik-Sit, Carolyn Klinge, Brian Clem   +5 more
openaire   +1 more source

Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide. [PDF]

, 2015
BackgroundTemozolomide (TMZ) is an oral DNA-alkylating agent used for treating patients with glioblastoma. However, therapeutic benefits of TMZ can be compromised by the expression of O6-methylguanine methyltransferase (MGMT) in tumor tissue.
Bui, Yvonne, Cloughesy, Timothy F, Hong, Irene, Lai, Albert, Liau, Linda M, McBride, William H, Menjivar, Jimmy C, Nelson, Stanley F, Stream, Alexandra, Tso, Cho-Lea, Tso, Jonathan L, Yamada, Kazunari, Yang, Shuai, Yong, William H, Zhang, Yibei   +14 more
core   +2 more sources

Season- and depth-dependent variability of a demersal fish assemblage in a large fjord estuary (Puget Sound, Washington) [PDF]

, 2011
Fjord estuaries are common along the northeast Pacific coastline, but little information is available on fish assemblage structure and its spatiotemporal variability. Here, we examined changes in diversity metrics, species biomasses, and biomass spectra (
Essington, Timothy E., Reum, Jonathan C. P.   +1 more
core  

Chromatin signature of embryonic pluripotency is established during genome activation [PDF]

, 2009
available in PMC 2011 April 8.After fertilization the embryonic genome is inactive until transcription is initiated during the maternal–zygotic transition. This transition coincides with the formation of pluripotent cells, which in mammals can be used to
A Barski, A Barski, A Sagasti, AF Schier, AF Schier, Alexander F. Schier, AN Boettiger, Aviv Regev, B Li, B Schuettengruber, BE Bernstein, DW Huang, Farhad Imam, FC Wardle, G Dennis, G Pan, GW Muse, H O’Geen, H Shin, HP Phatnani, Ian G. Woods, J Newport, J Zeitlinger, JK Stock, JL Rinn, John Rinn, JS Song, KM Dreijerink, LJ Core, M Vermeulen, MG Guenther, Nadine L. Vastenhouw, RC Akkers, SS Hammoud, T Yuzyuk, TS Mikkelsen, V Azuara, V Link, W Tadros, X. Shirley Liu, XD Zhao, Yong Zhang   +41 more
core   +1 more source

Shmt2: a stat3 signaling new player in prostate cancer energy metabolism [PDF]

, 2019
Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these pathways and its activation is implicated in the modulation of several metabolic enzymes.
Altieri, Fabio, Chichiarelli, Silvia, Eufemi, Margherita, Giamogante, Flavia, Gurtner, Aymone, Macone, Alberto, Magliocca, Fabio Massimo, Manganaro, Roberto, Maras, Bruno, Marrocco, Ilaria, Paglia, Giuliano, Patsilinakos, Alexandros, Perugia, Giacomo, Ragno, Rino, Rubini, Elisabetta   +14 more
core   +1 more source

PSAT1 enhances the efficacy of the prognosis estimation nomogram model in stage-based clear cell renal cell carcinoma

BMC Cancer
Background Clear cell renal cell carcinoma (ccRCC) is associated with a high prevalence of cancer-related deaths. The survival rates of patients are significantly lower in late-stage ccRCC than in early-stage ccRCC, due to the spread and metastasis of ...
Jun Wang, Xiaoming He, Yuanyuan Mi, Yong Q. Chen, Jie Li, Rong Wang   +5 more
doaj   +1 more source

Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron production [PDF]

, 2011
Background The production of nephrons suddenly ends in mice shortly after birth when the remaining cells of the multi-potent progenitor mesenchyme begin to differentiate into nephrons.
Eric W Brunskill, Hsiao L Lai, D Curtis Jamison, S Steven Potter, Larry T Patterson   +4 more
core   +1 more source

Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood [PDF]

, 2018
The nutritional environment to which animals are exposed in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life.
Ehara Tatsuya, Hamaguchi Miho, Hanzawa Nozomi, Hashimoto Koshi, Hatada Izuho, Itoh Nobuyuki, Kamei Yasutomi, Kawahori Kenichi, Kitamura Yohei, Konishi Morichika, Nakagawa Yoshimi, Nawa Makiko, Ogawa Yoshihiro, Seki Takami, Shimano Hitoshi, Takai-Igarashi Takako, Tsujimoto Kazutaka, Yuan Xunmei, 中川 嘉, 島野 仁   +19 more
core   +3 more sources

Additional file 3 of PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis

Additional file 3: Table S3. The differentially expressed mRNAs in PDLSCs after osteogenic induction.
Jia, Linglu, Li, Dongfang, Wang, Ya-Nan, Zhang, Dongjiao, Xu, Xin   +4 more
openaire   +1 more source