PSAT1 regulates hair follicle growth and stem cell behavior in cashmere goats [PDF]
BMC Veterinary ResearchBackground The Arbas Cashmere Goat from Inner Mongolia is renowned for its superior-quality cashmere, which is primarily produced by secondary hair follicles (SHFs).
Xiao-yu Han +11 more
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Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells [PDF]
Molecular Cancer, 2008 Background Colorectal cancer (CRC) is one of the most common causes of cancer death throughout the world. In this work our aim was to study the role of the phosphoserine aminotransferase PSAT1 in colorectal cancer development.
Nicole Bec +2 more
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Journal of Translational Medicine, 2023 Background Periodontal ligament stem cells (PDLSCs) are important seed cells for tissue engineering to realize the regeneration of alveolar bone. Understanding the gene regulatory mechanisms of osteogenic lineage differentiation in PDLSCs will facilitate
Linglu Jia +4 more
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Transcriptome Analysis Reveals the Molecular Mechanisms by Which ADAMTS1 Influences the Proliferation of Ovarian Granulosa Cells in Sheep [PDF]
AnimalsNormal proliferation of ovarian granulosa cells is essential for follicular development. The results of this study showed that ADAMTS1 was primarily localized in the cytoplasm of granulosa cells in sheep ovarian follicles, as revealed by ...
Rongqing Li +12 more
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ΔNp63α drives serine synthesis to promote carboplatin resistance in NSCLC [PDF]
Cell Death and DiseaseSerine metabolism is a critical vulnerability in cancer; however, its role in mediating therapeutic resistance in non-small cell lung cancer (NSCLC) remains incompletely understood.
Liyuan Deng +6 more
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PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress [PDF]
Diagnostic PathologyBackground Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, and a significant cause of visual impairment and blindness in adults. Phosphoserine aminotransferase 1 (PSAT1) is an enzyme participating in serine synthesis, which
Xiaofeng Du, Yanting Wang, Fan Gao
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Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms [PDF]
Cell Communication and SignalingSerine is a non-essential amino acid, serving as a precursor for other amino acids, lipids, and nucleotide synthesis. Its supply is ensured by two main mechanisms: exogenous uptake and endogenous synthesis.
Mincong Shu, Yuhan Liu, Jianbin Wang
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miR-424 Targets AKT3 and PSAT1 and Has a Tumor-Suppressive Role in Human Colorectal Cancer [Retraction] [PDF]
Cancer Management and ResearchFang Y, Liang X, Xu J, Cai X. Cancer Manag Res. 2018;10:6537–6547. We, the Editors and Publisher of the journal Cancer Management and Research, have retracted the published article.
Fang Y, Liang X, Xu J, Cai X
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Probing the role of Coniferin and Tetrahydrocurcumin from Traditional Chinese medicine against PSAT1 in early-stage ovarian cancer: An in silico study. [PDF]
PLoS ONEOvarian cancer, a formidable gynaecological malignancy, poses a significant global health challenge, and it is characterised by late-stage diagnosis and a high mortality rate. Even in its early stages, when treatment choices are scarce, ovarian cancer is
Jia Zhang +5 more
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Scientific Reports, 2018 Endocrine disrupting chemicals (EDC) interfere with the natural hormone balance and may induce epigenetic changes through exposure during sensitive periods of development.
Vera A. van der Weijden +2 more
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