Results 21 to 30 of about 5,276 (193)
Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH [PDF]
Cancer & MetabolismSerine metabolism provides important metabolic intermediates that support the rapid proliferation of tumor cells. However, the role of serine metabolism in esophageal squamous cell carcinoma (ESCC) and the underlying mechanism remains unclear.
Hui Jie +12 more
doaj +2 more sources
Identification and Validation of Serum Biomarkers to Improve Colorectal Cancer Diagnosis [PDF]
Cancer MedicineBackground The pressing need for reliable biomarkers in colorectal cancer (CRC) diagnosis and prognosis is a major global health concern. Current diagnostic methods rely heavily on invasive procedures like colonoscopy, and existing biomarkers such as ...
Minha Lea Yoon +5 more
doaj +2 more sources
Bioinformatics analysis of ferroptosis-related hub genes and immunoinfiltration in myocardial ischemia/reperfusion following heart transplantation [PDF]
BMC Cardiovascular DisordersBackground Ischemia/reperfusion (I/R) is an inevitable pathophysiological process during heart transplantation, and ferroptosis is an important pathogenic mechanism. Unlike other modes of cell death, ferroptosis depends on the accumulation of iron within
Yuxi Zhang +9 more
doaj +2 more sources
miR-424 targets AKT3 and PSAT1 and has a tumor-suppressive role in human colorectal cancer
Cancer Management and Research, 2018 Yifeng Fang,1 Xiao Liang,1 Junfen Xu,2 Xiujun Cai1 1Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; 2Department of Gynecologic Oncology, Women’s Hospital, Zhejiang University School
Fang Y, Liang X, Xu J, Cai X
doaj +4 more sources
Frontiers in Bioscience-Landmark, 2023 Purpose: Current evidence suggests that phosphoserine aminotransferase 1 (PSAT1) is overexpressed in various tumors. Herein, we investigate the significance of PSAT1 in non-small cell lung cancer (NSCLC) and its correlation with immune infiltration ...
Hongmu Li +8 more
doaj +1 more source
Frontiers in Genetics, 2022 This study analyzed PSAT1-targeted miRNAs as a prognostic predictor for gastric cancer. The relationship between the clinical manifestations of gastric cancer in patients and phosphoserine aminotransferase 1 (PSAT1) was analyzed using correlation ...
Jingwei Ma +7 more
doaj +1 more source
Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma [PDF]
Autophagy, 2019 GBM (glioblastoma multiforme) is the most common and aggressive brain tumor with no curative options available. Therefore, it is imperative to develop novel potent therapeutic drugs for GBM treatment. Here, we show that regorafenib, an oral multi-kinase inhibitor, exhibits superior therapeutic efficacy over temozolomide, the first-line chemotherapeutic
Jingwen Jiang +20 more
openaire +2 more sources
COMPUTER‐BASED VERBAL SCORE REPORTS: I. PSAT1 [PDF]
ETS Research Bulletin Series, 1967 ABSTRACTA system for analyzing PSAT score profiles and producing “conversational” interpretations in the form of letters to be sent to candidates is developed. The system utilizes a problem‐oriented computer language for the description of the analysis.
Stefan J. Harasymiw, Carl E. Helm
openaire +1 more source
Juvenile-onset PSAT1-related neuropathy: A milder phenotype of serine deficiency disorder
Frontiers in Genetics, 2022 Background: Primary serine deficiency disorders have a broad range of the phenotypic spectrum. As an inborn error of metabolism, individuals with severe phenotype may be easily recognized with Neu-Laxova syndrome. However, late-onset mild phenotypes may be underdiagnosed and will lead to disastrous consequences due to treatment delays.Materials and ...
Yu Shen +12 more
openaire +3 more sources
Overexpression of a Prefoldin β subunit gene reduces biomass recalcitrance in the bioenergy crop Populus. [PDF]
, 2020 Prefoldin (PFD) is a group II chaperonin that is ubiquitously present in the eukaryotic kingdom. Six subunits (PFD1-6) form a jellyfish-like heterohexameric PFD complex and function in protein folding and cytoskeleton organization.
Barry, Kerrie +20 more
core +1 more source