Results 31 to 40 of about 5,276 (193)

Overexpression of Phosphoserine Aminotransferase 1 (PSAT1) Predicts Poor Prognosis and Associates with Tumor Progression in Human Esophageal Squamous Cell Carcinoma

Cellular Physiology and Biochemistry, 2016
Background/Aims: Phosphoserine aminotransferase 1 (PSAT1) is over-expressed in many carcinoma tissues, however little is known regarding its expression and function in esophageal carcinogenesis.
Bingyan Liu, Yiping Jia, Yan Cao, Shaoqiu Wu, Haosheng Jiang, Xianjun Sun, Jun Ma, Xiang Yin, Aiwu Mao, Mingyi Shang   +9 more
doaj   +1 more source

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]

, 2016
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel, Christofk, Heather R, Graeber, Thomas G, Krall, Abigail S, Xu, Shili   +4 more
core   +1 more source

Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner

Endocrine Regulations, 2023
Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma.
Sliusar Myroslava Y., Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhij V., Ratushna Oksana O., Minchenko Oleksandr H.   +8 more
doaj   +1 more source

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth [PDF]

, 2016
We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20ppm in feed) or Reporcin (recombinant ...
A Bassols, A Conesa, A Méndez-Lucas, AA Sneddon, AM Gunawan, B Sève, C Chaosap, C Kung, CP Velloso, DM Brown, DM Spurlock, EE Vincent, FA Wilson, FFS Depreux, FR Dunshea, GM DeNicola, GS Lynch, H Rhinn, J Bush, J Yang, J Ye, JA Bush, JA Higgins, JK Apple, JM Brameld, JW Locasale, JW Locasale, K Leithner, KM Hemmings, L Norton, L Sun, M Ruusunen, M Sandri, M Vestergaard, MA Pearen, MT Sørensen, O Bohorov, PJ Buttery, PJ Reeds, PM Tedeschi, PS Ward, PW Emery, R Koopman, R Possemato, RG Campbell, RJ DeBerardinis, RJ Samms, S Bardocz, S Modaressi, SA Gahr, SC Kalhan, SY Lunt, T Kitaura, T Laeger, T Parr, TA Armstrong, TJ Caperna, WO Kline, YR Boisclair   +58 more
core   +3 more sources

PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3β/β-catenin/cyclin D1 signaling pathway in ER-negative breast cancer

Journal of Experimental & Clinical Cancer Research, 2017
Background A growing amount of evidence has indicated that PSAT1 is an oncogene that plays an important role in cancer progression and metastasis. In this study, we explored the expression and function of PSAT1 in estrogen receptor (ER)-negative breast ...
Song Gao, Anqi Ge, Shouping Xu, Zilong You, Shipeng Ning, Yashuang Zhao, Da Pang   +6 more
doaj   +1 more source

Restored microRNA-133a-3p or Depleted PSAT1 Restrains Endothelial Cell Damage-Induced Intracranial Aneurysm Via Suppressing the GSK3β/β-Catenin Pathway

Nanoscale Research Letters, 2020
It is unclear about the functional role of microRNA-133a-3p (miR-133a-3p) in intracranial aneurysm (IA). Hence, the aim of the present study was to investigate the regulatory role of miR-133a-3p on the regulation of vascular endothelial injury-induced IA
Qiang Jia, Shixin Yan, Jie Huang, Shixin Xu   +3 more
doaj   +1 more source

Screening and validation of Hub genes in bile acid-induced hepatocyte response based on transcriptome sequencing

陆军军医大学学报, 2023
Objective To screen and verify the Hub genes involved in conjugated bile acid-induced hepatocyte metabolism through transcriptome sequencing analysis. Methods Primary mouse hepatocytes were treated with taurocholic acid (TCA), and the gene expression of ...
ZHANG Mengni, ZHANG Mengni, ZHANG Xiaoxun, OUYANG Jiafeng, CHAI Jin   +4 more
doaj   +1 more source

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer [PDF]

, 2010
Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid cell growth and proliferation[superscript 1, 2]. RNA interference (RNAi)-based loss-of-function screening has proven powerful for the identification of new and ...
A Bric, A Marson, Abhishek K. Jha, Albert M. Chan, B Luo, Bingbing Yuan, D Wiederschain, DA Walsh, David E. Root, David M. Sabatini, Dohoon Kim, DR Rhodes, Edward M. Driggers, Elena F. Brachtel, FR Miller, FR Miller, Francesca G. Barrett, Glenn S. Cowley, Hin-Koon Woo, Hyun G. Jang, I Ben-Porath, J Debnath, J Kim, J Moffat, JM Buescher, Jordi Barretina, K Lund, K Snell, Kathleen Ottina, Kevin M. Marks, Kıvanç Birsoy, Levi A. Garraway, Mari Mino-Kenudson, Michael E. Pacold, MJ van de Vijver, Nada Y. Kalaany, Nicolas Stransky, NY Kalaany, Peggy P. Hsu, PP Hsu, R Beroukhim, RG Jones, Richard Possemato, RJ DeBerardinis, S Pollari, Shalini Sethumadhavan, TS Mikkelsen, Walter W. Chen, WE Knox, Y Achouri, Y Sancak, Yoav D. Shaul, Zhi-Yang Tsun   +52 more
core   +1 more source

Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene [PDF]

, 2014
Exemplified by cancer cells' preference for glycolysis, for example, the Warburg effect, altered metabolism in tumorigenesis has emerged as an important aspect of cancer in the past 10–20 years.
Zogg, Cheryl K.
core   +3 more sources

Expression of Serine Biosynthesis Pathway Genes in Breast Muscles of Iranian Native Turkeys with Divergent Feed Efficiency [PDF]

پژوهشهای علوم دامی ایران, 2022
Introduction: Feed is the main cost part of poultry production. High feed efficiency poultry produce less feed and less excrement per unit weight gain. Therefore, a comprehensive understanding of the biological mechanisms that control feed efficiency is ...
Zahra Pezeshkian, Seyed Ziaeddin Mirhoseini, Shahrokh Ghovvati, Esmaeil Ebrahimie   +3 more
doaj   +1 more source