Results 51 to 60 of about 5,276 (193)

Processes underlying the nutritional programming of embryonic development by iron deficiency in the rat [PDF]

, 2012
Peer reviewedPublisher ...
Gambling, Lorraine, Hayes, Helen, Langley-Evans, Simon C, McArdle, Harry J, McMullen, Sarah, Swali, Angelina   +5 more
core   +3 more sources

Overexpression of microRNA-195-5p reduces cisplatin resistance and angiogenesis in ovarian cancer by inhibiting the PSAT1-dependent GSK3β/β-catenin signaling pathway

Journal of Translational Medicine, 2019
Background Ovarian cancer (OC) is one of the leading causes for cancer-related deaths among women. MicroRNAs (miRs) have been proved to be vital to the development and progression of OC.
Jun Dai, Rujia Wei, Peihai Zhang, Beihua Kong   +3 more
doaj   +1 more source

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate [PDF]

, 2015
Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH ...
Abu-Remaileh, Monther, Chan, Sze Ham, Chen, Walter W., Cho, Sung Won, Chung, Haeyoon, Davidson, Shawn M, Fiske, Brian Prescott, Koh, Min Jung, Lewis, Caroline, Liu, Chieh Ming Jamin, Luengo, Alba, Pacold, Michael Edward, Sabatini, David, Sullivan, Lucas Bryan, Swier, Lotteke J. Y. M., Vander Heiden, Matthew G., Zhou, Minerva H.   +16 more
core   +1 more source

Overexpression of the PSAT1 Gene in Nasopharyngeal Carcinoma Is an Indicator of Poor Prognosis [PDF]

Journal of Cancer, 2016
Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and Southeast Asia, but risk stratification and treatment outcome in NPC patients remain suboptimal. Our study identified and validated metabolic drivers that are relevant to the pathogenesis of NPC using a published transcriptome.
Liao, Kuang-Ming, Chao, Tung-Bo, Tian, Yu-Feng, Lin, Ching-Yih, Lee, Sung-Wei, Chuang, Hua-Ying, Chan, Ti-Chun, Chen, Tzu-Ju, Hsing, Chung-Hsi, Sheu, Ming-Jen, Li, Chien-Feng   +10 more
openaire   +3 more sources

ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

Cell Reports, 2021
Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable ...
Xingyao Li, Daniel Gracilla, Lun Cai, Mingyi Zhang, Xiaolin Yu, Xiaoguang Chen, Junran Zhang, Xiaochun Long, Han-Fei Ding, Chunhong Yan   +9 more
doaj   +1 more source

Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis

, 2019
Erratum for: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Bardeesy, N., Boukhali, M., Chen, T., Dyson, N., Gu, H., Haas, W., Hammerman, P., Hayes, D., Hayward, M., Karnik, R., Kottakis, F., Li, Y., Liesa, M., Meissner, A., Nagle, J., Nicolay, B., Roumane, A., Shirihai, O., Wong, K.   +18 more
core   +1 more source

Elevated PSAT1 expression distinguishes basal-like human breast cancer.

, 2022
Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4). We mined published microarray data (5, 6) to understand in an unbiased fashion the most distinguishing transcriptional features of tumors from ...
openaire   +1 more source

Identification of potential ferroptosis hub genes in acute-on-chronic liver failure based on bioinformatics analysis and experimental verification

BMC Medical Genomics, 2023
Background Ferroptosis plays an important role in the development of acute-on-chronic liver failure (ACLF). The present project aimed to identify and validate the potential ferroptosis-related genes in ACLF by bioinformatics analysis and experimental ...
Meixia Kuang, Longhui Cai, Jing Zhao, Liqiao Huang, Yichun Ji, Bingyao Lv, Weihong Kuang   +6 more
doaj   +1 more source

Tissue metabolic changes drive cytokine responses to Mycobacterium tuberculosis [PDF]

, 2018
Cellular metabolism can influence host immune responses to Mycobacterium tuberculosis (Mtb). Using a systems biology approach, differential expression of 292 metabolic genes involved in glycolysis, glutathione, pyrimidine and inositol phosphate pathways ...
Joosten, LAB, Koeken, VACM, Kumar, V, Lachmandas, E, Li, Y, Matzaraki, V, Netea, MG, Notebaart, RA, Noursadeghi, M, Oosting, M, Pollara, G, Rios-Miguel, AB, van Crevel, R, van der Pasch, E   +13 more
core   +4 more sources

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target

Animal Models and Experimental Medicine, EarlyView.
We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
wiley   +1 more source