Results 1 to 10 of about 929,693 (286)

Chimeric non-antigen receptors in T cell-based cancer therapy

Journal for ImmunoTherapy of Cancer, 2021
Adoptively transferred T cell-based cancer therapies have shown incredible promise in treatment of various cancers. So far therapeutic strategies using T cells have focused on manipulation of the antigen-recognition machinery itself, such as through ...
Andrew Kent, Eduardo Davila, Jitao Guo
doaj   +1 more source

Therapeutic applications of engineered chimeric antigen receptors-T cell for cancer therapy

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Findings of new targeted treatments with adequate safety evaluations are essential for better cancer cures and mortality rates. Immunotherapy holds promise for patients with relapsed disease, with the ability to elicit long-term remissions ...
Amina Hussain
doaj   +1 more source

Toward high-throughput engineering techniques for improving CAR intracellular signaling domains

Frontiers in Bioengineering and Biotechnology, 2023
Chimeric antigen receptors (CAR) are generated by linking extracellular antigen recognition domains with one or more intracellular signaling domains derived from the T-cell receptor complex or various co-stimulatory receptors.
Savannah E. Butler, Savannah E. Butler, Colin J. Hartman, Colin J. Hartman, Yina H. Huang, Yina H. Huang, Margaret E. Ackerman, Margaret E. Ackerman   +7 more
doaj   +1 more source

[Chimeric antigen receptor T cells].

Bulletin du cancer, 2021
Chimeric antigen receptor T-cell (CAR T-cells) therapies which are genetically modified T lymphocyte targeting tumor antigens have modified therapeutic landscape in hematology. Aggressive B cells lymphoma are currently treated in daily practice with anti-CD19 CAR T.
Bories, Pierre, Ysebaert, Loïc
openaire   +2 more sources

Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. [PDF]

PLoS Pathogens, 2010
Exhausted CD8+ T cell responses during chronic viral infections are defined by a complex expression pattern of inhibitory receptors. However, very little information is currently available about the coexpression patterns of these receptors on human virus-
Bertram Bengsch, Bianca Seigel, Marianne Ruhl, Jörg Timm, Martin Kuntz, Hubert E Blum, Hanspeter Pircher, Robert Thimme   +7 more
doaj   +1 more source

A transfer-learning approach to predict antigen immunogenicity and T-cell receptor specificity

eLife, 2023
Antigen immunogenicity and the specificity of binding of T-cell receptors to antigens are key properties underlying effective immune responses. Here we propose diffRBM, an approach based on transfer learning and Restricted Boltzmann Machines, to build ...
Barbara Bravi, Andrea Di Gioacchino, Jorge Fernandez-de-Cossio-Diaz, Aleksandra M Walczak, Thierry Mora, Simona Cocco, Rémi Monasson   +6 more
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T-Cell Antigen Receptors

Dermatologic Clinics, 1990
We have reviewed the knowledge of the human TCR and its implications in dermatology. The TCR has been shown to be the molecule responsible for specific cellular immunity in the same way that immunoglobulins confer humoral immunity. Much has been learned about the complex genomic organization of the TCR chains and how the great diversity of TCR proteins
K, Degitz, S W, Caughman
openaire   +4 more sources

Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors

Frontiers in Immunology, 2020
Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical ...
Chloe H. Lee, Chloe H. Lee, Mariolina Salio, Giorgio Napolitani, Graham Ogg, Alison Simmons, Alison Simmons, Hashem Koohy, Hashem Koohy   +8 more
doaj   +1 more source

Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors

Frontiers in Immunology, 2021
Chimeric antigen receptor (CAR) T cell therapy has shown unprecedented success in treating advanced hematological malignancies. Its effectiveness in solid tumors has been limited due to heterogeneous antigen expression, a suppressive tumor ...
Navid Ghahri-Saremi, Behnia Akbari, Tahereh Soltantoyeh, Jamshid Hadjati, Saba Ghassemi, Hamid Reza Mirzaei   +5 more
doaj   +1 more source

A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes [PDF]

, 1989
Peptides that are antigenic for T lymphocytes are ligands for two receptors, the class I or II glycoproteins that are encoded by genes in the major histocompatibility complex, and the idiotypic / chain T-cell antigen receptor1–9. That a peptide must bind
A Sette, A Townsend, B Babbitt, C DeLisi, DW Thomas, GM Keil, H Margalit, H Volkmer, HC Bodmer, JB Rothbard, JB Rothbard, Jonathan B. Rothbard, M Del Val, Matthias J. Reddehase, MBA Oldstone, MF Good, MJ Reddehase, MJ Reddehase, MJ Reddehase, MM Davis, N Shastri, P Marrack, PJ Bjorkman, PM Allen, R Shimonkevitz, RH Schwartz, RH Schwartz, RM Zinkernagel, S Buus, UH Koszinowski, Ulrich H. Koszinowski   +30 more
core   +1 more source