Results 1 to 10 of about 1,489,547 (334)
T-cell antigen receptor genes and T-cell recognition [PDF]
Nature, 1988 The four distinct T-cell antigen receptor polypeptides (alpha, beta, gamma, delta) form two different heterodimers (alpha:beta and gamma:delta) that are very similar to immunoglobulins in primary sequence, gene organization and modes of rearrangement.
Mark M. Davis, P. Bjorkman
semanticscholar +3 more sources
Engineering and Design of Chimeric Antigen Receptors
Molecular Therapy: Methods & Clinical Development, 2019 T cells engineered with chimeric antigen receptors (CARs) have emerged as a potent new class of therapeutics for cancer, based on their remarkable potency in blood cancers.
Sonia Guedan +3 more
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Chimeric antigen receptors that trigger phagocytosis
eLife, 2018 Chimeric antigen receptors (CARs) are synthetic receptors that reprogram T cells to kill cancer. The success of CAR-T cell therapies highlights the promise of programmed immunity and suggests that applying CAR strategies to other immune cell lineages may
Meghan A Morrissey +6 more
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Chimeric non-antigen receptors in T cell-based cancer therapy
Journal for ImmunoTherapy of Cancer, 2021 Adoptively transferred T cell-based cancer therapies have shown incredible promise in treatment of various cancers. So far therapeutic strategies using T cells have focused on manipulation of the antigen-recognition machinery itself, such as through ...
Andrew Kent, Eduardo Davila, Jitao Guo
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Therapeutic applications of engineered chimeric antigen receptors-T cell for cancer therapy
Beni-Suef University Journal of Basic and Applied Sciences, 2022 Background Findings of new targeted treatments with adequate safety evaluations are essential for better cancer cures and mortality rates. Immunotherapy holds promise for patients with relapsed disease, with the ability to elicit long-term remissions ...
Amina Hussain
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Toward high-throughput engineering techniques for improving CAR intracellular signaling domains
Frontiers in Bioengineering and Biotechnology, 2023 Chimeric antigen receptors (CAR) are generated by linking extracellular antigen recognition domains with one or more intracellular signaling domains derived from the T-cell receptor complex or various co-stimulatory receptors.
Savannah E. Butler +7 more
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[Chimeric antigen receptor T cells].
Bulletin du cancer, 2021 Chimeric antigen receptor T-cell (CAR T-cells) therapies which are genetically modified T lymphocyte targeting tumor antigens have modified therapeutic landscape in hematology. Aggressive B cells lymphoma are currently treated in daily practice with anti-CD19 CAR T.
Bories, Pierre, Ysebaert, Loïc
openaire +2 more sources
Long-term outcomes following CAR T cell therapy: what we know so far
Nature Reviews Clinical Oncology, 2023 Chimeric antigen receptors (CAR) are engineered fusion proteins designed to target T cells to antigens expressed on cancer cells. CAR T cells are now an established treatment for patients with relapsed and/or refractory B cell lymphomas, B cell acute ...
Kathryn M. Cappell, J. Kochenderfer
semanticscholar +1 more source
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. [PDF]
PLoS Pathogens, 2010 Exhausted CD8+ T cell responses during chronic viral infections are defined by a complex expression pattern of inhibitory receptors. However, very little information is currently available about the coexpression patterns of these receptors on human virus-
Bertram Bengsch +7 more
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A transfer-learning approach to predict antigen immunogenicity and T-cell receptor specificity
eLife, 2023 Antigen immunogenicity and the specificity of binding of T-cell receptors to antigens are key properties underlying effective immune responses. Here we propose diffRBM, an approach based on transfer learning and Restricted Boltzmann Machines, to build ...
Barbara Bravi +6 more
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