Results 11 to 20 of about 836,416 (221)
Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors
Frontiers in Immunology, 2020 Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical ...
Chloe H. Lee +8 more
doaj +1 more source
Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors
Frontiers in Immunology, 2021 Chimeric antigen receptor (CAR) T cell therapy has shown unprecedented success in treating advanced hematological malignancies. Its effectiveness in solid tumors has been limited due to heterogeneous antigen expression, a suppressive tumor ...
Navid Ghahri-Saremi +5 more
doaj +1 more source
Regulator T Cells: Specific for Antigen and/or Antigen Receptors? [PDF]
Scandinavian Journal of Immunology, 2003 AbstractAdaptive immune responses are regulated by many different molecular and cellular effectors. Regulator T cells are coming to their rights again, and these T cells seem to have ordinary α/β T‐cell receptors (TCRs) and to develop in the thymus. Autoimmune responses are tightly regulated by such regulatory T cells, a phenomenon which is beneficial ...
B. Rubin +3 more
openaire +3 more sources
A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers
Nature Communications, 2022 Antigen escape represents a potential drawback of chimeric antigen receptor T cell (CAR-T) therapy targeting a single tumor-associated antigen. To reduce the risk of antigen escape, here the authors report the design and characterization of a BAFF ligand
Derek P. Wong +12 more
doaj +1 more source
Nature Network Boston, 2015 Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens.
Adrienne H. Long +14 more
semanticscholar +1 more source
Comparison of lentiviral and sleeping beauty mediated αβ T cell receptor gene transfer. [PDF]
PLoS ONE, 2013 Transfer of tumour antigen-specific receptors to T cells requires efficient delivery and integration of transgenes, and currently most clinical studies are using gamma retroviral or lentiviral systems.
Anne-Christine Field +9 more
doaj +1 more source
T cell antigen discovery via Signaling and Antigen presenting Bifunctional Receptors
Nature Methods, 2019 CD8+ T cells recognize and eliminate tumors in an antigen-specific manner. Despite progress in characterizing the antitumor T cell repertoire and function, the identification of target antigens remains a challenge.
Alok V. Joglekar +11 more
semanticscholar +1 more source
F1000Research, 2014 The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj +1 more source
Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects
Frontiers in Immunology, 2022 To redirect T cells against tumor cells, T cells can be engineered ex vivo to express cancer-antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T cells (TCR T).
Paul Shafer +7 more
doaj +1 more source
High-throughput determination of the antigen specificities of T cell receptors in single cells
Nature Biotechnology, 2018 We present tetramer-associated T-cell receptor sequencing (TetTCR-seq) to link T cell receptor (TCR) sequences to their cognate antigens in single cells at high throughput.
Shuqi Zhang +8 more
semanticscholar +1 more source