Results 11 to 20 of about 929,693 (286)

Chimeric Antigen Receptor T-Cell Therapy [PDF]

Journal of the National Comprehensive Cancer Network, 2018
Patients with relapsed or refractory (R/R) cancers have a poor prognosis and limited treatment options. The recent approval of 2 chimeric antigen receptor (CAR) autologous T-cell products for R/R B-cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma treatment is setting the stage for what is possible in other diseases.
Ndiya, Ogba, Nicole M, Arwood, Nancy L, Bartlett, Mara, Bloom, Patrick, Brown, Christine, Brown, Elizabeth Lihua, Budde, Robert, Carlson, Stephanie, Farnia, Terry J, Fry, Morgan, Garber, Rebecca A, Gardner, Lauren, Gurschick, Patricia, Kropf, Jeff J, Reitan, Craig, Sauter, Bijal, Shah, Elizabeth J, Shpall, Steven T, Rosen   +18 more
openaire   +2 more sources

Chimeric Antigen Receptors for T-Cell Malignancies

Frontiers in Oncology, 2019
Development of chimeric antigen receptor (CAR)-modified T cells for the treatment of T-lineage leukemia and lymphoma has encountered several unique challenges. The most widely expressed tumor antigen targets for malignant T cells are often also expressed
Lauren D. Scherer, Lauren D. Scherer, Malcolm K. Brenner, Malcolm K. Brenner, Malcolm K. Brenner, Maksim Mamonkin, Maksim Mamonkin, Maksim Mamonkin, Maksim Mamonkin   +8 more
doaj   +1 more source

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer [PDF]

, 2012
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
A Lundqvist, A Somers, C Berger, CA Tran, Carolina Berger, Cornelis JM Melief, Daniel J Powell, David F Stroncek, DG Song, DJ Powell Jr, DL Porter, Francesco M Marincola, G Mostoslavsky, GG Kenter, Gustavo Mostoslavsky, J Jin, J Staerk, James R Heath, Jeffrey S Miller, JN Kochenderfer, JN Kochenderfer, John O'Shea, JS Miller, K Takahashi, L Gattinoni, L Gattinoni, L Gattinoni, L Gattinoni, LA Johnson, Luca Gattinoni, M Kalos, M Kalos, M Kalos, Mahendra Rao, Mark E Dudley, Martin A Cheever, ME Dudley, ME Dudley, Michael Kalos, Nicholas P Restifo, P Muranski, Peter Flynn, PF Robbins, RA Morgan, Richard W Childs, SA Rosenberg, Steven A Rosenberg, TS Park, X Wang   +48 more
core   +4 more sources

Inhibition of the inositol kinase Itpkb augments calcium signaling in lymphocytes and reveals a novel strategy to treat autoimmune disease [PDF]

, 2015
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of the negative regulatory inositol ...
A Kontzias, Albert Parker, Andrew T. Miller, AT Miller, AT Miller, AT Miller, AT Miller, AT Miller, Ben G. Wen, BG Wen, Carol Dahlberg, Christian Schmedt, CM Walsh, Cynthia Cienfuegos, D Communi, Daniel R. Beisner, Derya Unutmaz, E Sandalova, GS Bird, H. Martin Seidel, J Liou, Jacqueline Avis, Janet Dawson, JC Mercer, John A. H. Hoerter, JP Yuan, K Cante-Barrett, K Sauer, KD Kim, LA O'Neill, LM Broad, M Chvanov, M Fukuda, M Oh-hora, M Oh-Hora, M Prakriya, M Vig, M Vig, Mark L. Sandberg, Mark McPate, Martin Gosling, MC Hermosura, Michael P. Cooke, MK Schuhmann, Monique Stinson, N Beyersdorf, Pamela Tranter, Paul J. Groot-Kormelink, PG Hogan, PH Krammer, PP Chamberlain, R Holmdahl, RA Wilcox, S Feske, Shifeng Pan, Shin-Shay Tian, V Pouillon, Y Gwack, Y Marechal, YH Huang   +59 more
core   +12 more sources

The second touch hypothesis: T cell activation, homing and polarization [v1; ref status: indexed, http://f1000r.es/2w7]

F1000Research, 2014
The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj   +1 more source

The second touch hypothesis: T cell activation, homing and polarization [v2; ref status: indexed, http://f1000r.es/3zq]

F1000Research, 2014
The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj   +1 more source

A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers

Nature Communications, 2022
Antigen escape represents a potential drawback of chimeric antigen receptor T cell (CAR-T) therapy targeting a single tumor-associated antigen. To reduce the risk of antigen escape, here the authors report the design and characterization of a BAFF ligand
Derek P. Wong, Nand K. Roy, Keman Zhang, Anusha Anukanth, Abhishek Asthana, Nicole J. Shirkey-Son, Samantha Dunmire, Bryan J. Jones, Walker S. Lahr, Beau R. Webber, Branden S. Moriarity, Paolo Caimi, Reshmi Parameswaran   +12 more
doaj   +1 more source

Tracking global changes induced in the CD4 T-cell receptor repertoire by immunization with a complex antigen using short stretches of CDR3 protein sequence. [PDF]

, 2014
The clonal theory of adaptive immunity proposes that immunological responses are encoded by increases in the frequency of lymphocytes carrying antigen-specific receptors. In this study, we measure the frequency of different T-cell receptors (TcR) in CD4 +
Best, K, Chain, B, Cinelli, M, Friedman, N, Gal, H, Madi, A, Reich-Zeliger, S, Shawe-Taylor, J, Shifrut, E, Thomas, N   +9 more
core   +1 more source

Chimeric antigen receptor T cell

Indian Journal of Pharmacology, 2022
During present decade, targeted drug therapy has been the epitome for treatment of cancer. Drugs like Imatinib, a tyrosine kinase receptor inhibitor and Trastuzumab, an human epidermal growth factor receptor-2/neu inhibitor, has been developed and accepted widely for management of chronic myeloid leukaemia and breast cancer ...
Singh, Surjit, Khasbage, Sameer, Kaur, Rimple Jeet, Sidhu, Jaspreet Kaur, Bhandari, Bharti   +4 more
openaire   +2 more sources

Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects

Frontiers in Immunology, 2022
To redirect T cells against tumor cells, T cells can be engineered ex vivo to express cancer-antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T cells (TCR T).
Paul Shafer, Paul Shafer, Paul Shafer, Lauren M. Kelly, Lauren M. Kelly, Lauren M. Kelly, Valentina Hoyos, Valentina Hoyos   +7 more
doaj   +1 more source