Results 31 to 40 of about 836,416 (221)

Gene modification strategies for next-generation CAR T cells against solid cancers

Journal of Hematology & Oncology, 2020
Immunotherapies have become the backbone of cancer treatment. Among them, chimeric antigen receptor (CAR) T cells have demonstrated great success in the treatment of hematological malignancies.
Yonggui Tian, Yilu Li, Yupei Shao, Yi Zhang   +3 more
doaj   +1 more source

Genes Encoding the T-Cell Antigen Receptor

Journal of Investigative Dermatology, 1985
The search for the elusive and controversial T-cell antigen receptor is over. It is now clear that gene complexes for both alpha and beta chains are distinct from those for immunoglobulin genes. They are, however, related to Ig genes as well as to other class I and class II major histocompatibility complex (MHC) gene products. Therefore, they belong to
Nicolette Caccia, Barry Toyonaga, Uik Sohn, Yasunobu Yoshikai, Nobuhiro Kimura, Tak W. Mak, Veronica Vadasz, Tammy Cook   +7 more
openaire   +4 more sources

Post-translational covalent assembly of CAR and synNotch receptors for programmable antigen targeting

Nature Communications, 2023
Chimeric antigen receptors (CARs) and synthetic Notch (synNotch) receptors are engineered cell-surface receptors that sense a target antigen and respond by activating T cell receptor signaling or a customized gene program, respectively.
Elisa Ruffo, Adam A. Butchy, Yaniv Tivon, Victor So, Michael Kvorjak, Avani Parikh, Eric L. Adams, Natasa Miskov-Zivanov, Olivera J. Finn, Alexander Deiters, Jason Lohmueller   +10 more
doaj   +1 more source

Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings [PDF]

arXiv, 2022
Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in treating blood cancers, and its application to solid tumors is currently being extensively investigated. For glioma brain tumors, various CAR T-cell targets include IL13Ra2, EGFRvIII, HER2, EphA2, GD2, B7-H3, and chlorotoxin.
arxiv  

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

Nature Communications, 2019
T cells expressing CD19-targeting chimeric antigen receptors (CARs) reveal high efficacy in the treatment of B cell malignancies. Here, we report that T cell receptor fusion constructs (TRuCs) comprising an antibody-based binding domain fused to T cell ...
P. Baeuerle, Jian Ding, Ekta S Patel, N. Thorausch, H. Horton, J. Gierut, Irene Scarfò, R. Choudhary, O. Kiner, J. Krishnamurthy, B. Le, A. Morath, G. Baldeviano, Justin Quinn, P. Tavares, Q. Wei, S. Weiler, M. Maus, D. Getts, W. Schamel, R. Hofmeister   +20 more
semanticscholar   +1 more source

Gene Expression-Based Identification of Antigen-Responsive CD8+ T Cells on a Single-Cell Level

Frontiers in Immunology, 2019
CD8+ T cells are important effectors of adaptive immunity against pathogens, tumors, and self antigens. Here, we asked how human cognate antigen-responsive CD8+ T cells and their receptors could be identified in unselected single-cell gene expression ...
Yannick F. Fuchs, Virag Sharma, Virag Sharma, Anne Eugster, Gloria Kraus, Robert Morgenstern, Andreas Dahl, Susanne Reinhardt, Andreas Petzold, Annett Lindner, Doreen Löbel, Ezio Bonifacio, Ezio Bonifacio, Ezio Bonifacio   +13 more
doaj   +1 more source

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Journal of Clinical Investigation, 2017
Chimeric antigen receptor (CAR) T cells have been highly successful in treating hematological malignancies, including acute and chronic lymphoblastic leukemia.
P. Beavis, M. Henderson, Lauren Giuffrida, J. Mills, K. Sek, R. Cross, A. Davenport, Liza B. John, Sherly Mardiana, C. Slaney, R. Johnstone, J. Trapani, J. Stagg, S. Loi, Lev M. Kats, D. Gyorki, M. Kershaw, P. Darcy   +17 more
semanticscholar   +1 more source

Large-scale GPU-based network analysis of the human T-cell receptor repertoire [PDF]

arXiv, 2021
Understanding the structure of the human T-cell receptor repertoire is a crucial precondition to understand the ability of the immune system to recognize and respond to antigens. T-cells are often compared via the complementarity determining region 3 (CDR3) of their respective T-cell receptor beta chains.
arxiv  

Detecting T-cell receptors involved in immune responses from single repertoire snapshots [PDF]

PLoS Biol 17(6): e3000314 (2019), 2018
Hypervariable T-cell receptors (TCR) play a key role in adaptive immunity, recognising a vast diversity of pathogen-derived antigens. High throughput sequencing of TCR repertoires (RepSeq) produces huge datasets of T-cell receptor sequences from blood and tissue samples.
arxiv   +1 more source

Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System

Frontiers in Immunology, 2020
Recent advancements in single cell sequencing technologies allow for identification of numerous immune-receptors expressed by T cells such as tumor-specific and autoimmune T cells.
Sarah E. Mann, Zhicheng Zhou, Laurie G. Landry, Amanda M. Anderson, Aimon K. Alkanani, Jeremy Fischer, Mark Peakman, Roberto Mallone, Roberto Mallone, Kristen Campbell, Aaron W. Michels, Aaron W. Michels, Maki Nakayama, Maki Nakayama, Maki Nakayama   +14 more
doaj   +1 more source