Results 31 to 40 of about 929,693 (286)
Chimeric Antigen Receptor beyond CAR-T Cells [PDF]
Cancers, 2021 Chimeric antigen receptors (CAR) are genetically engineered receptors that can recognise specific antigens and subsequently activate downstream signalling. Human T cells engineered to express a CAR, also known as CAR-T cells, can target a specific tumour antigen on the cell surface to mediate a cytotoxic response against the tumour.
Vicky Mengfei Qin +3 more
openaire +3 more sources
Developing T-cell therapies for lymphoma without receptor engineering
Blood Advances, 2017 : T-cell therapy has emerged from the bench for the treatment of patients with lymphoma. Responses to T-cell therapeutics are regulated by multiple factors, including the patient's immune system status and disease stage.
Melanie Grant, Catherine M. Bollard
doaj +1 more source
A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells [PDF]
, 2007 Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ T cells. However, very little is known about the impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between peptide–major
Allen, R +18 more
core +3 more sources
Haematologica, 2008 Background Donor lymphocyte infusion is an effective form of adoptive immunotherapy for hematologic malignancies after allogeneic stem cell transplantation.
Marieke Griffioen +9 more
doaj +1 more source
Gene modification strategies for next-generation CAR T cells against solid cancers
Journal of Hematology & Oncology, 2020 Immunotherapies have become the backbone of cancer treatment. Among them, chimeric antigen receptor (CAR) T cells have demonstrated great success in the treatment of hematological malignancies.
Yonggui Tian +3 more
doaj +1 more source
Genome-Edited T Cell Therapies [PDF]
, 2017 PURPOSE OF REVIEW: Alternative approaches to conventional drug-based cancer treatments have seen T cell therapies deployed more widely over the last decade.
Delhove, JMKM, Qasim, W
core +1 more source
Gene Expression-Based Identification of Antigen-Responsive CD8+ T Cells on a Single-Cell Level
Frontiers in Immunology, 2019 CD8+ T cells are important effectors of adaptive immunity against pathogens, tumors, and self antigens. Here, we asked how human cognate antigen-responsive CD8+ T cells and their receptors could be identified in unselected single-cell gene expression ...
Yannick F. Fuchs +13 more
doaj +1 more source
Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System
Frontiers in Immunology, 2020 Recent advancements in single cell sequencing technologies allow for identification of numerous immune-receptors expressed by T cells such as tumor-specific and autoimmune T cells.
Sarah E. Mann +14 more
doaj +1 more source
Nature Communications, 2023 Chimeric antigen receptors (CARs) and synthetic Notch (synNotch) receptors are engineered cell-surface receptors that sense a target antigen and respond by activating T cell receptor signaling or a customized gene program, respectively.
Elisa Ruffo +10 more
doaj +1 more source
An Influenza Virus M2 Protein Specific Chimeric Antigen Receptor Modulates Influenza A/WSN/33 H1N1 Infection In Vivo [PDF]
, 2013 A potential target for the development of universal vaccine strategies against Influenza A is the M2 protein – a membrane protein with a highly conserved extracellular domain.
Blair, Natalie F +5 more
core +1 more source