Results 31 to 40 of about 54,159 (319)
Frontiers in Microbiology, 2021 National screening programs use dried blood specimens to detect metabolic disorders or aberrant protein functions that are not clinically evident in the neonatal period.
Anne-Christine Aust +10 more
doaj +1 more source
Obesity and cancer: existing and new hypotheses for a causal connection [PDF]
, 2018 Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly, but recent evidence suggests a major role for chronic inflammation in cancer
Darlington, L. Gail +2 more
core +2 more sources
Frontiers in Immunology, 2020 ObjectivesSemaphorin 4D (Sema4D) is constitutively expressed on T cells and osteoclasts, and regulates T cell proliferation and bone remodeling. In addition, several studies have shown that Sema4D is involved in the pathogenesis of autoimmunity.
Jianmin Xie, Zitao Wang, Wen Wang
doaj +1 more source
AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor
Nature Communications, 2017 In this work the authors show that AIP (aryl hydrocarbon receptor-interacting protein), a gene frequently mutated in association with pituitary tumors, regulates neurotransmitter release by inhibiting calcium release from ryanodine receptors.
Bojun Chen +5 more
doaj +1 more source
Role of gut microbiota-derived signals in the regulation of gastrointestinal motility
Frontiers in Medicine, 2022 The gastrointestinal (GI) tract harbors trillions of commensal microbes, called the gut microbiota, which plays a significant role in the regulation of GI physiology, particularly GI motility.
Zhipeng Zheng +3 more
doaj +1 more source
Xenobiotic receptors in mediating the effect of sepsis on drug metabolism
Acta Pharmaceutica Sinica B, 2020 Sepsis is an infection-induced systemic inflammatory syndrome. The immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory pathways.
Chuanzhu Lv, Ling Huang
doaj +1 more source
Transcriptional regulation of innate lymphoid cells and T cells by aryl hydrocarbon receptor
Frontiers in Immunology, 2023 The aryl hydrocarbon receptor (Ahr) is a ligand-dependent transcription factor and facilitates immune cell environmental sensing through its activation by cellular, dietary, and microbial metabolites, as well as environmental toxins.
Eric Y. Helm, Liang Zhou
doaj +1 more source
Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context [PDF]
, 2012 The aryl hydrocarbon receptor (AhR) mediates the induction of a variety of xenobiotic metabolism genes. Activation of the AhR occurs through binding to a group of structurally diverse compounds, most notably dioxins, which are exogenous ligands ...
BALBONI, GIANFRANCO +10 more
core +1 more source
Aryl hydrocarbon receptor and intestinal immunity [PDF]
Mucosal Immunology, 2018 Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular responses to environmental stimuli, such as xenobiotics and oxygen levels. Unlike other members of bHLH, AhR is the only bHLH transcription factor that is known to be ligand activated.
Lamas, Bruno +2 more
openaire +3 more sources
Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene [PDF]
, 2017 Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene.
Catchpole, B +5 more
core +2 more sources