Results 71 to 80 of about 2,311,393 (299)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Selection of reference genes for RT-qPCR analysis in Coccinella septempunctata to assess un-intended effects of RNAi transgenic plants

Frontiers in Plant Science, 2016
The development of genetically-engineered plants that employ RNA interference (RNAi) to suppress invertebrate pests opens up new avenues for insect control.
Chunxiao Yang, Chunxiao Yang, Chunxiao Yang, Evan L. Preisser, Hongjun Zhang, Hongjun Zhang, Yong Liu, Liangying Dai, Huipeng Pan, Huipeng Pan, Xuguo Zhou   +10 more
doaj   +1 more source

1000 Norms Project: Protocol of a cross-sectional study cataloging human variation [PDF]

, 2015
Background Clinical decision-making regarding diagnosis and management largely depends on comparison with healthy or ‘normal’ values. Physiotherapists and researchers therefore need access to robust patient-centred outcome measures and appropriate ...
Baldwin, Jennifer N., Burns, Joshua, Chard, Angus, Ferreira, Paulo, Fong Yan, Alycia, Hiller, Claire E., Hübscher, Markus, Mackey, Martin G., McKay, Marnee J., Moloney, Niamh A., Mousavi, Seyed J., Nicholson, Leslie L., Nightingale, Elizabeth J., on behalf of the 1000 Norms Project Consortium, Pourkazemi, Fereshteh, Quinlan, Kate G., Raymond, Jacqueline, Refshauge, Kathryn M., Rose, Kristy, Simic, Milena, Sman, Amy D., Vanicek, Natalie, Wegener, Caleb   +22 more
core   +2 more sources

AutDB: a gene reference resource for autism research [PDF]

Nucleic Acids Research, 2008
Recent advances in studies of Autism Spectrum Disorders (ASD) has uncovered many new candidate genes and continues to do so at an accelerated pace. To address the genetic complexity of ASD, we have developed AutDB (http://www.mindspec.org/autdb.html), a publicly available web-portal for on-going collection, manual annotation and visualization of genes ...
Basu, Saumyendra N., Kollu, Ravi, Banerjee-Basu, Sharmila   +2 more
openaire   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Selection and validation of reference genes for RT-qPCR-based analyses of Anastatus japonicus Ashmead (Hymenoptera: Helicopteridae)

Frontiers in Physiology, 2022
RT-qPCR remains a vital approach for molecular biology studies aimed at quantifying gene expression in a range of physiological or pathological settings.
Zixin Liu, Zixin Liu, Junjiang Xiao, Junjiang Xiao, Yue Xia, Qifeng Wu, Qifeng Wu, Can Zhao, Dunsong Li   +8 more
doaj   +1 more source

Motor Nucleus of the Trigeminal Nerve [PDF]

, 2008
This report contains a summary of expression patterns for genes that are enriched in the motor nucleus of the trigeminal nerve (V) of the pons. All data is derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project. The structure's
Allen Institute for Brain Science, Angela L. Guillozet-Bongaarts, Lydia L. Ng, Nicholas A. Kostakis   +3 more
core   +2 more sources

Postmenopausal Osteoporosis reference genes for qPCR expression assays [PDF]

Scientific Reports, 2019
AbstractOsteoporosis (OP) is a multifactorial disease influenced by genetic factors in more than half of the cases. In spite of the efforts to clarify the relationship among genetic factors and susceptibility to develop OP, many genetic associations need to be further functionally validated.
Camilla Albertina Dantas de Lima, Suelen Cristina de Lima, Alexandre Domingues Barbosa, Paula Sandrin-Garcia, Will de Barros Pita, Jaqueline de Azevêdo Silva, Sergio Crovella   +6 more
openaire   +4 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

A full-length S1 gene sequencing of a novel emerged GI-19 and GI-23 lineages of Infectious bronchitis virus currently circulating in chicken flocks in upper Egypt reveals marked genetic diversity and recombination events

Virology Journal
Background Infectious bronchitis virus (IBV) is a highly contagious evolving pathogen that causes respiratory, urinary and reproductive symptoms; threatening the poultry industry globally.
Eman Shosha, Sara Abdelnaser, Ali Mahmoud Zanaty   +2 more
doaj   +1 more source