Results 1 to 10 of about 25,833 (119)

Dynamic Regulation of Ferroptosis in a Neonatal Rat Model of Postnatal Hypoxia-Induced Acute Kidney Injury [PDF]

Antioxidants
Hypoxia during the postnatal period represents a significant risk factor for renal injury in neonates, yet the molecular mechanisms linking oxygen deprivation to kidney damage remain unclear. In this study, we explored whether ferroptosis serves as a key
Tzu-Hao Liu, Bo-Hau Chen, Guan-Hong Lin, Hsin-Hung Chen, Hsiang-Chin Chiu, Chih-Chieh Yang, Yi-Ting Chu, Ching-Ming Lin, Wen-Hsien Lu   +8 more
doaj   +2 more sources

The Role of the Pyruvate Dehydrogenase Complex in the Development of Ischemic-Reperfusion Syndrome

Кубанский научный медицинский вестник, 2022
Background. One of the key components of energy metabolism is the pyruvate dehydrogenase complex (PDC), the activity of which can be targeted by some cytoprotectors. However, their role remains unclear. It is known that the activation of the PDC in tumor
K. A. Popov, Ya. E. Denisova, I. M. Bykov, I. Yu. Tsymbalyuk, G. A. Ermakova, A. G. Zavgorodnyaya, A. S. Shevchenko   +6 more
doaj   +1 more source

Overcoming Hypoxia-Induced Drug Resistance via Promotion of Drug Uptake and Reoxygenation by Acousto–Mechanical Oxygen Delivery

Pharmaceutics, 2022
Hypoxia-induced drug resistance (HDR) is a critical issue in cancer therapy. The presence of hypoxic tumor cells impedes drug uptake and reduces the cytotoxicity of chemotherapeutic drugs, leading to HDR and increasing the probability of tumor recurrence
Yi-Ju Ho, Dinh Thi Thao, Chih-Kuang Yeh
doaj   +1 more source

Novel Targets in a High-Altitude Pulmonary Hypertension Rat Model Based on RNA-seq and Proteomics

Frontiers in Medicine, 2021
High-altitude pulmonary hypertension (HAPH) is a complication arising from an inability to acclimatize to high altitude and is associated with high morbidity and mortality.
Xiang Xu, Hanlu Li, Qingxia Wei, Xin Li, Xin Li, Yanying Shen, Ge Guo, Yibing Chen, Kunlun He, Kunlun He, Chunlei Liu, Chunlei Liu   +11 more
doaj   +1 more source

Myostatin Deficiency Protects C2C12 Cells from Oxidative Stress by Inhibiting Intrinsic Activation of Apoptosis

Cells, 2021
Ischemia reperfusion (IR) injury remains an important topic in clinical medicine. While a multitude of prophylactic and therapeutic strategies have been proposed, recent studies have illuminated protective effects of myostatin inhibition. This study aims
Marius Drysch, Sonja Verena Schmidt, Mustafa Becerikli, Felix Reinkemeier, Stephanie Dittfeld, Johannes Maximilian Wagner, Mehran Dadras, Alexander Sogorski, Maxi von Glinski, Marcus Lehnhardt, Björn Behr, Christoph Wallner   +11 more
doaj   +1 more source

In Vitro Modeling of Reoxygenation Effects on mRNA and Protein Levels in Hypoxic Tumor Cells upon Entry into the Bloodstream

Cells, 2020
Background: Solid epithelial tumors like breast cancer are the most frequent malignancy in women. Circulating tumor cells (CTCs) are frequently released from hypoxic areas into the blood, where CTCs face elevated oxygen concentrations. This reoxygenation
Kai Bartkowiak, Claudia Koch, Sebastian Gärtner, Antje Andreas, Tobias M Gorges, Klaus Pantel   +5 more
doaj   +1 more source

Phosphorylation in Novel Mitochondrial Creatine Kinase Tyrosine Residues Render Cardioprotection against Hypoxia/Reoxygenation Injury

Journal of Lipid and Atherosclerosis, 2021
Objective Ischemic cardiomyopathy (ICM) is the leading cause of heart failure. Proteomic and genomic studies have demonstrated ischemic preconditioning (IPC) can assert cardioprotection against ICM through mitochondrial function regulation.
Nammi Park, Jubert Marquez, Maria Victoria Faith Garcia, Ippei Shimizu, Sung Ryul Lee, Hyoung Kyu Kim, Jin Han   +6 more
doaj   +1 more source

The Acute Effect of Erythropoietin on Mean Platelet Volume Levels during Hypoxia Reoxygenation Injury in Rats

Haseki Tıp Bülteni, 2016
Aim: This biomedical study tested the effect of erythropoietin (Epo) in rat model, especially in a hypoxia-reoxygenation one. The trend of this factor was evaluated hematologically using serum mean platelets volume (MPV) values. Methods: Forty rats with
Constantinos Tsompos, Constantinos Panoulis, Konstantinos Toutouzas, George Zografos, Aggeliki Triantafyllou, Apostolos Papalois   +5 more
doaj   +1 more source

Performance of a Trickling-Bed Biocathode Microbial Electrochemical System Treating Domestic Wastewater and Functional Microbial Community Characteristics

Applied Sciences, 2020
Biocathode microbial electrochemical systems (MESs) that remove nitrogen compounds out of wastewater are of special interest for practice. High energy-input for aeration is one of the barriers that hinder their application on a wider scope.
Haiman Wang, Zhuang Miao, Lei Chao, Yafeng Li, Guiqiang Wang   +4 more
doaj   +1 more source

Mitochondrial plasticity supports proliferative outgrowth and invasion of ovarian cancer spheroids during adhesion

Frontiers in Oncology, 2023
BackgroundOvarian cancer cells aggregate during or after exfoliation from the primary tumor to form threedimensional spheroids. Spheroid formation provides a survival advantage during peritoneal dissemination in nutrient and oxygen-depleted conditions ...
Joseph P. Grieco, Stephanie L. E. Compton, Nazia Bano, Lucy Brookover, Anna S. Nichenko, Joshua C. Drake, Eva M. Schmelz   +6 more
doaj   +1 more source