Results 11 to 20 of about 25,961 (244)

Checking in on Hypoxia/Reoxygenation [PDF]

Cell Cycle, 2006
Hypoxia/reoxygenation is a physiological stress that activates the DNA damage pathway. Significantly, this pathway is initiated during hypoxia, in the absence of detectable DNA damage. Our most recent study determined that during hypoxia, Chk 2 is phosphorylated in an ATM-dependent manner.
Rachel A, Freiberg, Adam J, Krieg, Amato J, Giaccia, Ester M, Hammond   +3 more
openaire   +2 more sources

The hypoxia–reoxygenation stress in plants [PDF]

Journal of Experimental Botany, 2020
AbstractPlants are very plastic in adapting growth and development to changing adverse environmental conditions. This feature will be essential for plants to survive climate changes characterized by extreme temperatures and rainfall. Although plants require molecular oxygen (O2) to live, they can overcome transient low-O2 conditions (hypoxia) until ...
José León, Mari Cruz Castillo, Beatriz Gayubas   +2 more
openaire   +3 more sources

Green Fluorescent Protein is a Suitable Reporter of Tumor Hypoxia Despite an Oxygen Requirement for Chromophore Formation

Neoplasia: An International Journal for Oncology Research, 2001
The oxygen requirement for chromophore formation potentially limits the use of green fluorescent protein as a reporter under hypoxic conditions. In the light of this, the applicability of a hypoxia-responsive enhanced green fluorescent protein (EGFP ...
Dirk Vordermark, Toru Shibata, J. Martin Brown   +2 more
doaj   +1 more source

Icariside II, a PDE5 Inhibitor, Suppresses Oxygen-Glucose Deprivation/Reperfusion-Induced Primary Hippocampal Neuronal Death Through Activating the PKG/CREB/BDNF/TrkB Signaling Pathway

Frontiers in Pharmacology, 2020
BackgroundIschemic stroke remains the leading cause of death and adult disability. Cerebral ischemic/reperfusion (I/R) injury is caused by ischemic stroke thereafter aggravates overwhelming neuronal apoptosis and even the death of neurons.
Fan Xu, Chun Lv, Yan Deng, Yuangui Liu, Qihai Gong, Jingshan Shi, Jianmei Gao   +6 more
doaj   +1 more source

Modeling of Hypoxic Brain Injury through 3D Human Neural Organoids

Cells, 2021
Brain organoids have emerged as a novel model system for neural development, neurodegenerative diseases, and human-based drug screening. However, the heterogeneous nature and immature neuronal development of brain organoids generated from pluripotent ...
Min Soo Kim, Da-Hyun Kim, Hyun Kyoung Kang, Myung Geun Kook, Soon Won Choi, Kyung-Sun Kang   +5 more
doaj   +1 more source

Perioperative GABA Blood Concentrations in Infants with Cyanotic and Non-Cyanotic Congenital Heart Diseases

Diagnostics, 2021
Perioperative stress detection in children with congenital heart disease (CHD), particularly in the brain, is still limited. Among biomarkers, γ-amino-aminobutyric acid (GABA) assessment in biological fluids appears to be promising for its regulatory ...
Angela Satriano, Alessandro Varrica, Alessandro Frigiola, Alessandro Graziosi, Caterina Di Battista, Adele Patrizia Primavera, Giacomo Centini, Antonio Maconi, Chiara Strozzi, Antonio D. W. Gavilanes, Luc J. Zimmermann, Hans J. S. Vles, Diego Gazzolo   +12 more
doaj   +1 more source

Oxidative injury in reoxygenated and reperfused hearts [PDF]

Free Radical Biology and Medicine, 1994
In this study, we separated the effects of low oxygen supply and low coronary flow in isolated perfused rat hearts to focus on the genesis of free radicals-induced reperfusion injury. Hearts were exposed to either hypoxemia/reoxygenation or ischemia/reperfusion in various sequences, with hypoxemia and ischemia matched for duration (20 min), temperature
M. SAMAJA, R. MOTTERLINI, F. SANTORO, G. DELLANTONIO, A. CORNO   +4 more
openaire   +3 more sources

The Acute Effect of the Antioxidant Drug U-74389G on Red Blood Cell Distribution Width Levels During Hypoxia Reoxygenation Injury in Rats

Folia Medica, 2015
The AIM of this experimental study was to evaluate the effect of the antioxidant drug “U-74389G” in a rat model of hypoxia reoxygenation (HR) using the previously established protocol.
Tsompos Constantinos, Panoulis Constantinos, Toutouzas Konstantinos, Zografos George, Papalois Apostolos   +4 more
doaj   +1 more source

The Plenus Cold Event Record in the Abyssal DSDP Site 367 (Cape Verde, Central Atlantic): Environmental Perturbations and Impacts on the Nitrogen Cycle

Frontiers in Earth Science, 2021
The Oceanic Anoxic Event 2, at the Cenomanian-Turonian boundary (∼93.9 Ma), was an episode of widespread burial of organic matter in marine sediments, underlined by a positive carbon-isotope (δ13C) excursion observed worldwide.
Laurent Riquier, Pierre Cadeau, Pierre Cadeau, Julien Danzelle, François Baudin, Emmanuelle Pucéat, Christophe Thomazo, Christophe Thomazo   +7 more
doaj   +1 more source

Reoxygenation Reverses Hypoxic Pulmonary Arterial Remodeling by Inducing Smooth Muscle Cell Apoptosis via Reactive Oxygen Species–Mediated Mitochondrial Dysfunction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundPulmonary arterial remodeling, a main characteristic of hypoxic pulmonary hypertension, can gradually reverse once oxygen has been restored.
Jian Chen, Yan‐Xia Wang, Ming‐Qing Dong, Bo Zhang, Ying Luo, Wen Niu, Zhi‐Chao Li   +6 more
doaj   +1 more source