Results 31 to 40 of about 53,784 (251)

Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes

Journal of Diabetes Research, 2019
Diabetes aggravates myocardial ischemia-reperfusion (I/R) injury because of the combination effects of changes in glucose and lipid energy metabolism, oxidative stress, and systemic inflammatory response.
Zhen Qiu, Yu-Hong He, Ming Hao, S. Lei, Y. Leng, Z. Xia   +5 more
semanticscholar   +1 more source

Perioperative GABA Blood Concentrations in Infants with Cyanotic and Non-Cyanotic Congenital Heart Diseases

Diagnostics, 2021
Perioperative stress detection in children with congenital heart disease (CHD), particularly in the brain, is still limited. Among biomarkers, γ-amino-aminobutyric acid (GABA) assessment in biological fluids appears to be promising for its regulatory ...
Angela Satriano, Alessandro Varrica, Alessandro Frigiola, Alessandro Graziosi, Caterina Di Battista, Adele Patrizia Primavera, Giacomo Centini, Antonio Maconi, Chiara Strozzi, Antonio D. W. Gavilanes, Luc J. Zimmermann, Hans J. S. Vles, Diego Gazzolo   +12 more
doaj   +1 more source

Oxidative injury in reoxygenated and reperfused hearts [PDF]

Free Radical Biology and Medicine, 1994
In this study, we separated the effects of low oxygen supply and low coronary flow in isolated perfused rat hearts to focus on the genesis of free radicals-induced reperfusion injury. Hearts were exposed to either hypoxemia/reoxygenation or ischemia/reperfusion in various sequences, with hypoxemia and ischemia matched for duration (20 min), temperature
M. SAMAJA, R. MOTTERLINI, F. SANTORO, G. DELLANTONIO, A. CORNO   +4 more
openaire   +3 more sources

The Plenus Cold Event Record in the Abyssal DSDP Site 367 (Cape Verde, Central Atlantic): Environmental Perturbations and Impacts on the Nitrogen Cycle

Frontiers in Earth Science, 2021
The Oceanic Anoxic Event 2, at the Cenomanian-Turonian boundary (∼93.9 Ma), was an episode of widespread burial of organic matter in marine sediments, underlined by a positive carbon-isotope (δ13C) excursion observed worldwide.
Laurent Riquier, Pierre Cadeau, Pierre Cadeau, Julien Danzelle, François Baudin, Emmanuelle Pucéat, Christophe Thomazo, Christophe Thomazo   +7 more
doaj   +1 more source

The Acute Effect of the Antioxidant Drug U-74389G on Red Blood Cell Distribution Width Levels During Hypoxia Reoxygenation Injury in Rats

Folia Medica, 2015
The AIM of this experimental study was to evaluate the effect of the antioxidant drug “U-74389G” in a rat model of hypoxia reoxygenation (HR) using the previously established protocol.
Tsompos Constantinos, Panoulis Constantinos, Toutouzas Konstantinos, Zografos George, Papalois Apostolos   +4 more
doaj   +1 more source

Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor

Molecular Medicine Reports, 2020
During the reperfusion phase of ischemia-reperfusion injury, reactive oxygen species (ROS) production aggravates the course of many diseases, including acute kidney injury.
T. Eleftheriadis, G. Pissas, G. Filippidis, V. Liakopoulos, I. Stefanidis   +4 more
semanticscholar   +1 more source

Reoxygenation Reverses Hypoxic Pulmonary Arterial Remodeling by Inducing Smooth Muscle Cell Apoptosis via Reactive Oxygen Species–Mediated Mitochondrial Dysfunction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundPulmonary arterial remodeling, a main characteristic of hypoxic pulmonary hypertension, can gradually reverse once oxygen has been restored.
Jian Chen, Yan‐Xia Wang, Ming‐Qing Dong, Bo Zhang, Ying Luo, Wen Niu, Zhi‐Chao Li   +6 more
doaj   +1 more source

Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-κB pathway

Metabolism: Clinical and Experimental, 2018
Background AMP-activated Protein Kinase (AMPK) is a stress-activated kinase that protects against cardiomyocyte injury during ischemia and reperfusion.
Xu Chen, Xuan Li, Wenyan Zhang, Jie He, Bo Xu, Bowen Lei, Zhen-Hua Wang, Courtney A. Cates, T. Rousselle, Ji Li   +9 more
semanticscholar   +1 more source

Hepatopancreas Transcriptome Profiling Analysis Reveals Physiological Responses to Acute Hypoxia and Reoxygenation in Juvenile Qingtian Paddy Field Carp Cyprinus carpio var qingtianensis

Frontiers in Physiology, 2020
The Qingtian paddy field carp (Cyprinus carpio var qingtianensis) is a local carp cultivated in the rice field of Qingtian county, Zhejiang province, China.
Ming Qi, Ming Qi, Qianqian Wu, Tao Liu, Tao Liu, Yiling Hou, Yiling Hou, Yixin Miao, Yixin Miao, Menghong Hu, Menghong Hu, Qigen Liu, Qigen Liu   +12 more
doaj   +1 more source

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

ACS Central Science, 2019
Mitochondrial Ca2+ (mCa2+) uptake mediated by the mitochondrial calcium uniporter (MCU) plays a critical role in signal transduction, bioenergetics, and cell death, and its dysregulation is linked to several human diseases. In this study, we report a new
Joshua J. Woods, Neeharika Nemani, S. Shanmughapriya, Akshay Kumar, Meng-Qi Zhang, Sarah R. Nathan, M. Thomas, Edmund Carvalho, Karthik Ramachandran, Subramanya Srikantan, Peter B. Stathopulos, Justin J. Wilson, M. Madesh   +12 more
semanticscholar   +1 more source