Results 21 to 30 of about 53,784 (251)

In Vitro Modeling of Reoxygenation Effects on mRNA and Protein Levels in Hypoxic Tumor Cells upon Entry into the Bloodstream

Cells, 2020
Background: Solid epithelial tumors like breast cancer are the most frequent malignancy in women. Circulating tumor cells (CTCs) are frequently released from hypoxic areas into the blood, where CTCs face elevated oxygen concentrations. This reoxygenation
Kai Bartkowiak, Claudia Koch, Sebastian Gärtner, Antje Andreas, Tobias M Gorges, Klaus Pantel   +5 more
doaj   +1 more source

N6-methyladenosine reader YTH N6-methyladenosine RNA binding protein 3 or insulin like growth factor 2 mRNA binding protein 2 knockdown protects human bronchial epithelial cells from hypoxia/reoxygenation injury by inactivating p38 MAPK, AKT, ERK1/2, and NF-κB pathways

Bioengineered, 2021
Lung ischemia/reperfusion (I/R) injury (LIRI) is a common complication after lung transplantation, embolism, and trauma. N6-methyladenosine (m6A) methylation modification is implicated in the pathogenesis of I/R injury.
K. Xiao, Peng Liu, P. Yan, Yanxin Liu, Li-cheng Song, Yuhong Liu, Lixin Xie   +6 more
semanticscholar   +1 more source

Phosphorylation in Novel Mitochondrial Creatine Kinase Tyrosine Residues Render Cardioprotection against Hypoxia/Reoxygenation Injury

Journal of Lipid and Atherosclerosis, 2021
Objective Ischemic cardiomyopathy (ICM) is the leading cause of heart failure. Proteomic and genomic studies have demonstrated ischemic preconditioning (IPC) can assert cardioprotection against ICM through mitochondrial function regulation.
Nammi Park, Jubert Marquez, Maria Victoria Faith Garcia, Ippei Shimizu, Sung Ryul Lee, Hyoung Kyu Kim, Jin Han   +6 more
doaj   +1 more source

Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation [PDF]

, 2007
Ischemia is a major cause of brain damage, and patient management is complicated by the paradoxical injury that results from reoxygenation. We have now explored the generation of reactive oxygen species (ROS) in hippocampal and cortical neurons in ...
SCORZIELLO, ANTONELLA, Abramov, A.Y., Duchen, M.R., Abramov AY, Scorziello, A., Duchen MR   +5 more
core   +1 more source

METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

Autophagy, 2019
N6-methyladenosine (m6A) mRNA modifications play critical roles in various biological processes. However, no study addresses the role of m6A in macroautophagy/autophagy. Here, we show that m6A modifications are increased in H/R-treated cardiomyocytes and
Hui-Wen Song, Xing Feng, Heng Zhang, Yun-mei Luo, Juan Huang, Mei-Hua Lin, Jun-Fei Jin, Xue Ding, Shujing Wu, He Huang, T. Yu, Mukun Zhang, Hai-Ou Hong, S. Yao, Yong-Xiang Zhao, Zhi-Yong Zhang   +15 more
semanticscholar   +1 more source

Performance of a Trickling-Bed Biocathode Microbial Electrochemical System Treating Domestic Wastewater and Functional Microbial Community Characteristics

Applied Sciences, 2020
Biocathode microbial electrochemical systems (MESs) that remove nitrogen compounds out of wastewater are of special interest for practice. High energy-input for aeration is one of the barriers that hinder their application on a wider scope.
Haiman Wang, Zhuang Miao, Lei Chao, Yafeng Li, Guiqiang Wang   +4 more
doaj   +1 more source

Mitochondrial plasticity supports proliferative outgrowth and invasion of ovarian cancer spheroids during adhesion

Frontiers in Oncology, 2023
BackgroundOvarian cancer cells aggregate during or after exfoliation from the primary tumor to form threedimensional spheroids. Spheroid formation provides a survival advantage during peritoneal dissemination in nutrient and oxygen-depleted conditions ...
Joseph P. Grieco, Stephanie L. E. Compton, Nazia Bano, Lucy Brookover, Anna S. Nichenko, Joshua C. Drake, Eva M. Schmelz   +6 more
doaj   +1 more source

Green Fluorescent Protein is a Suitable Reporter of Tumor Hypoxia Despite an Oxygen Requirement for Chromophore Formation

Neoplasia: An International Journal for Oncology Research, 2001
The oxygen requirement for chromophore formation potentially limits the use of green fluorescent protein as a reporter under hypoxic conditions. In the light of this, the applicability of a hypoxia-responsive enhanced green fluorescent protein (EGFP ...
Dirk Vordermark, Toru Shibata, J. Martin Brown   +2 more
doaj   +1 more source

Icariside II, a PDE5 Inhibitor, Suppresses Oxygen-Glucose Deprivation/Reperfusion-Induced Primary Hippocampal Neuronal Death Through Activating the PKG/CREB/BDNF/TrkB Signaling Pathway

Frontiers in Pharmacology, 2020
BackgroundIschemic stroke remains the leading cause of death and adult disability. Cerebral ischemic/reperfusion (I/R) injury is caused by ischemic stroke thereafter aggravates overwhelming neuronal apoptosis and even the death of neurons.
Fan Xu, Chun Lv, Yan Deng, Yuangui Liu, Qihai Gong, Jingshan Shi, Jianmei Gao   +6 more
doaj   +1 more source

Modeling of Hypoxic Brain Injury through 3D Human Neural Organoids

Cells, 2021
Brain organoids have emerged as a novel model system for neural development, neurodegenerative diseases, and human-based drug screening. However, the heterogeneous nature and immature neuronal development of brain organoids generated from pluripotent ...
Min Soo Kim, Da-Hyun Kim, Hyun Kyoung Kang, Myung Geun Kook, Soon Won Choi, Kyung-Sun Kang   +5 more
doaj   +1 more source