Results 1 to 10 of about 17,947 (141)
Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1 [PDF]
Cell Reports, 2015 RIPK1 and RIPK3, two closely related RIPK family members, have emerged as important regulators of pathologic cell death and inflammation. In the current work, we report that the Bcr-Abl inhibitor and anti-leukemia agent ponatinib is also a first-in-class
Malek Najjar +13 more
doaj +6 more sources
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation [PDF]
Nature Communications, 2019 RIPK1 kinase activity is known to transduce a death signal, but the molecular mechanisms that normally prevent RIPK1 activation are unclear. Here, the authors report that IKK-mediated phosphorylation on RIPK1 Ser25 directly represses its enzymatic ...
Yves Dondelinger +14 more
doaj +3 more sources
A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1 [PDF]
Nature CommunicationsTumor necrosis factor (TNF)-induced RIPK1-mediated cell death is implicated in various human diseases. However, the mechanisms RIPK1-mediated cell death is regulated by metabolic processes remain unclear.
Tianhao Zou +14 more
doaj +2 more sources
Targeting RIPK1 to modulate cell death and tumour microenvironment in cancer therapy [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryReceptor-interacting serine/threonine-protein kinase 1 (RIPK1) is crucial in regulating inflammation, apoptosis, and necroptosis. Accumulating evidence highlights RIPK1 as a promising therapeutic target for various human diseases, including ...
Jing Chen +4 more
doaj +2 more sources
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2023 Amaç: Quercetin kolon kanseri dahil birçok kanser çeşidinde anti-kanser aktivite gösteren bir bileşiktir. Ancak, quercetinin nekroptoz yolağı üzerine etkilerini gösteren çalışmalar kısıtlıdır ve bu nedenle bu çalışmada quercetinin nekroptoz yolağına ...
Haydar Bağış +3 more
doaj +1 more source
Necroptosis: A Novel Pathway in Neuroinflammation
Frontiers in Pharmacology, 2021 Neuroinflammation is a complex inflammatory process in the nervous system that is expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis that triggers innate immune responses by rupturing dead cells and releasing ...
Ziyu Yu +4 more
doaj +1 more source
Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1
Frontiers in Cellular and Infection Microbiology, 2022 Dengue virus (DENV) infection is the most prevalent arthropod-borne virus disease and is endemic in more than 100 countries. Several DENV proteins have been shown to target crucial human host proteins to evade innate immune responses and establish a ...
Darshika J. Udawatte +4 more
doaj +1 more source
npj Breast Cancer, 2021 The triple-negative breast carcinoma (TNBC) is the most aggressive subtype of breast cancer. In TNBC, Aquaporin 1 (AQP1), a water-transporting transmembrane protein, is aberrantly enriched in cytoplasm and causes tumor cell death evasion.
Zhuming Yin +7 more
doaj +1 more source
Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation [PDF]
, 2020 Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases.
Bertrand, Mathieu +11 more
core +1 more source
RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development
Frontiers in Immunology, 2023 Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors.
Thomas Hägglöf +6 more
doaj +1 more source