Results 111 to 120 of about 18,020 (210)

To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function

Molecular & Cellular Oncology, 2018
Complex posttranslational modifications determine the effects of receptor-interacting protein kinase-1 (RIPK1) on cell survival and death. Studies from us and others have revealed a p38MAPK/MK2-dependent checkpoint in RIPK1 signaling.
Manoj B. Menon, Julia Gropengießer, Klaus Ruckdeschel, Matthias Gaestel   +3 more
doaj   +1 more source

The structure of mouse RIPK1 RHIM-containing domain as a homo-amyloid and in RIPK1/RIPK3 complex [PDF]

Nature Communications
Receptor-interacting protein kinase 1 (RIPK1) is a therapeutic target in treating neurodegenerative diseases and cancers. RIPK1 has three distinct functional domains, with the center domain containing a receptor-interacting protein homotypic interaction motif (RHIM), which mediates amyloid formation.
Jing Liu, Xia-lian Wu, Jing Zhang, Bing Li, Hua-yi Wang, Jian Wang, Jun-xia Lu   +6 more
openaire   +3 more sources

Bacillus cereus Induces Necroptosis in Microglia via the RIPK1/3‐MLKL Pathway

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Bacillus cereus induces necroptosis in murine/human microglia via the RIPK1/3‐MLKL pathway, triggering inflammatory cytokine release—uncovering a new pathogenic mechanism for its severe ocular infection. ABSTRACT Bacillus cereus endophthalmitis is a rapidly progressing intraocular infection that often results in poor visual outcomes due to extensive ...
Jing Yang, Bianjin Sun, Huijing Xu, Yangyang Shen, Huili Ye, Qiheng Yuan, Siwen Chen, Meiqin Zheng   +7 more
wiley   +1 more source

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells [PDF]

, 2019
Modern molecular medicine demands techniques to efficiently deliver molecules directly into mammalian cells. As proteins are the final mediators of most cellular pathways, efficient intracellular protein delivery techniques are highly desired.
Braeckmans, Kevin, Brans, Toon, Declercq, Wim, Fraire, Juan, Raemdonck, Koen, Raes, Laurens, Roelandt, Ria, Saelens, Xavier, Stremersch, Stephan, Van Hoecke, Lien, Vandenabeele, Peter   +10 more
core   +2 more sources

Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 4, April 2026.
Within minutes after ischemia onset, deprivation of oxygen and glucose leads to rapid ATP depletion, resulting in failure of Na+/K+‐ATPase activity and membrane depolarization. This ionic imbalance promotes uncontrolled synaptic release of glutamate and excessive activation of postsynaptic NMDA and AMPA receptors.
Meibiao Zhang, Jianxun Hou, Jia Kuang, Lei Hao, Zhao Yang   +4 more
wiley   +1 more source

Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis

Nature Communications
Dysfunctional NF-κB signaling is critically involved in inflammatory bowel disease (IBD). We investigated the mechanism by which RIPK1 and TRADD, two key mediators of NF-κB signaling, in mediating intestinal pathology using TAK1 IEC deficient model.
Ziyu Sun, Jianyu Ye, Weimin Sun, Libo Jiang, Bing Shan, Mengmeng Zhang, Jingyi Xu, Wanjin Li, Jianping Liu, Hongyang Jing, Tian Zhang, Meiling Hou, Cen Xie, Rongling Wu, Heling Pan, Junying Yuan   +15 more
doaj   +1 more source

Molecular crosstalk between apoptosis, necroptosis, and survival signaling [PDF]

, 2015
Our current knowledge of the molecular mechanisms regulating the signaling pathways leading to cell survival, cell death, and inflammation has shed light on the tight mutual interplays between these processes.
Bertrand, Mathieu, Kaiser, William J, Vanden Berghe, Tom, Vandenabeele, Peter   +3 more
core   +2 more sources

The Many Sides of RIPK1

Journal of Human Immunity
Introduction RIPK1 is a key regulator for mediating inflammatory signaling and cell death. This includes apoptosis, necroptosis, and innate immune signaling. Given these important functions of RIPK1, abnormalities in its pathway can lead to immune deficiency and/or autoinflammatory disease, with autosomal dominant ...
Andrea Janis, Joao Pedro Lopes
openaire   +1 more source

Role of necroptosis in the pathogenesis of solid organ injury [PDF]

, 2015
Necroptosis is a type of regulated cell death dependent on the activity of receptor-interacting serine/threonine-protein (RIP) kinases. However, unlike apoptosis, it is caspase independent.
Eguchi, S, Jaffer, T, Linkermann, A, Ma, D, Wang, Z, Zhao, H   +5 more
core   +1 more source

RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy

EMBO Reports
RIPK1 is a crucial regulator of cell survival, inflammation and cell death. Human RIPK1 deficiency leads to early-onset intestinal inflammation and peripheral T cell imbalance, though its role in αβT cell-mediated intestinal homeostasis remains unclear ...
Jelle Huysentruyt, Wolf Steels, Mario Ruiz Pérez, Bruno Verstraeten, Tatyana Divert, Kayleigh Flies, Kelly Lemeire, Nozomi Takahashi, Elke De Bruyn, Marie Joossens, Andrew S Brown, Bart N Lambrecht, Wim Declercq, Tom Vanden Berghe, Jonathan Maelfait, Peter Vandenabeele, Peter Tougaard   +16 more
doaj   +1 more source