Results 111 to 120 of about 17,697 (207)
Caspase-8 inhibition represses initial human monocyte activation in septic shock model [PDF]
, 2016 In septic patients, the onset of septic shock occurs due to the over-activation of monocytes. We tested the therapeutic potential of directly targeting innate immune cell activation to limit the cytokine storm and downstream phases.
Caballero-Velázquez, Teresa +10 more
core +2 more sources
The structure of mouse RIPK1 RHIM-containing domain as a homo-amyloid and in RIPK1/RIPK3 complex [PDF]
Nature CommunicationsReceptor-interacting protein kinase 1 (RIPK1) is a therapeutic target in treating neurodegenerative diseases and cancers. RIPK1 has three distinct functional domains, with the center domain containing a receptor-interacting protein homotypic interaction motif (RHIM), which mediates amyloid formation.
Jing Liu +6 more
openaire +3 more sources
Role of necroptosis in the pathogenesis of solid organ injury [PDF]
, 2015 Necroptosis is a type of regulated cell death dependent on the activity of receptor-interacting serine/threonine-protein (RIP) kinases. However, unlike apoptosis, it is caspase independent.
Eguchi, S +5 more
core +1 more source
Frontiers in Aging NeuroscienceNecroptosis is implicated in the pathogenesis of ischemic stroke. However, the mechanism underlying the sequential recruitment of receptor-interacting protein kinase 1 (RIPK1) and N-ethylmaleimide-sensitive fusion ATPase (NSF) in initiating necroptosis ...
Xincheng Song +10 more
doaj +1 more source
Molecular & Cellular Oncology, 2018 Complex posttranslational modifications determine the effects of receptor-interacting protein kinase-1 (RIPK1) on cell survival and death. Studies from us and others have revealed a p38MAPK/MK2-dependent checkpoint in RIPK1 signaling.
Manoj B. Menon +3 more
doaj +1 more source
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. [PDF]
, 2013 A long-standing controversy is whether autophagy is a bona fide cause of mammalian cell death. We used a cell-penetrating autophagy-inducing peptide, Tat-Beclin 1, derived from the autophagy protein Beclin 1, to investigate whether high levels of ...
Clarke, P.G. +13 more
core +1 more source
Necroptosis of Glycolytic Dendritic Cells Enhances Activation of Gamma Delta T Cells [PDF]
, 2016 Gamma delta (gd) T lymphocytes are a poorly understood class of immune cells that accumulate at sites of inflammation due to infection or autoimmunity. Part of the mystery of this T cell subset derives from lack of knowledge of ligands that bind to the T
Bashant, Kathleen R
core +1 more source
Journal of Human ImmunityIntroduction RIPK1 is a key regulator for mediating inflammatory signaling and cell death. This includes apoptosis, necroptosis, and innate immune signaling. Given these important functions of RIPK1, abnormalities in its pathway can lead to immune deficiency and/or autoinflammatory disease, with autosomal dominant ...
Andrea Janis, Joao Pedro Lopes
openaire +1 more source
Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. I. Effect of Lipopolysaccharide on Innate Immunity [PDF]
, 2015 The dysregulation of endometrial immune response to bacterial lipopolysaccharide (LPS) has been implicated in uterine disease and infertility in the postpartum dairy cow, although the mechanisms are not clear.
Abudureyimu, A +4 more
core +2 more sources
NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II [PDF]
, 2016 Incontinentia Pigmenti (IP) is a rare X-linked disease characterized by early male lethality and multiple abnormalities in heterozygous females. IP is caused by NF-κB essential modulator (NEMO) mutations.
Draber, P +4 more
core +1 more source