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The Involvement of RIPK1 in Alopecia Areata

International Journal of Molecular Sciences
We have previously demonstrated that receptor-interacting serine threonine kinase 1 (RIPK1) is expressed in hair follicles and regulates the hair cycle. In a mouse model, RIPK1 inhibitors also accelerated the telogen-to-anagen transition and elongated the anagen period. Here, we first investigated the involvement of RIPK1 in alopecia areata (AA).
Hyunju Kim +6 more
openaire +2 more sources

Autoinflammation due to RIPK1 Defects

Journal of Human Immunity
Introduction RIPK1 plays a role in mediating apoptosis, necroptosis, and inflammatory pathways downstream of death receptors and pattern recognition receptors. Loss-of-function mutations of RIPK1 have been shown to lead to immune deficiencies and/or autoinflammation. Cleavage resistant RIPK1-induced autoinflammatory
Kristen Mikhail, Joao Pedro Lopes
openaire +1 more source

Eupatolide, isolated from Liriodendron tulipifera, sensitizes TNF-mediated dual modes of apoptosis and necroptosis by disrupting RIPK1 ubiquitination

Heliyon
Ubiquitination of RIPK1 plays an essential role in the recruitment of the IKK complex, an upstream component of pro-survival NF-κB. It also limits TNF-induced programmed cell death by inhibiting the spatial transition from TNFR1-associated complex-I to ...
Kyeong Ah Park +7 more
doaj +1 more source

Development of a RIPK1 degrader to enhance antitumor immunity

Nature Communications
The scaffolding function of receptor interacting protein kinase 1 (RIPK1) confers intrinsic and extrinsic resistance to immune checkpoint blockades (ICBs) and emerges as a promising target for improving cancer immunotherapies.
Xin Yu +12 more
doaj +1 more source

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima +18 more
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Nucleic acid sensors and programmed cell death [PDF]