Results 11 to 20 of about 17,697 (207)

Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation

Molecular Metabolism, 2023
Objectives: Type 1 diabetes (T1D) is caused by progressive immune-mediated loss of insulin-producing β-cells. Inflammation is detrimental to β-cell function and survival, moreover, both apoptosis and necrosis have been implicated as mechanisms of β-cell ...
Tatiana Takiishi, Peng Xiao, Marie Franchimont, Eduardo H. Gilglioni, Erick N. Arroba, Esteban N. Gurzov, Mathieu JM. Bertrand, Alessandra K. Cardozo   +7 more
doaj   +3 more sources

RIPK1-Associated Inborn Errors of Innate Immunity [PDF]

Frontiers in Immunology, 2021
RIPK1 (receptor-interacting serine/threonine-protein kinase 1) is a key molecule for mediating apoptosis, necroptosis, and inflammatory pathways downstream of death receptors (DRs) and pattern recognition receptors (PRRs).
Jiahui Zhang, Jiahui Zhang, Taijie Jin, Taijie Jin, Ivona Aksentijevich, Qing Zhou, Qing Zhou   +6 more
doaj   +3 more sources

NLK facilitates Caspase-8 activation to drive macrophage PANoptosis in sepsis. [PDF]

Clin Transl Med
By promoting Caspase‐8 activation within the PANoptosome, NLK modulates pyroptotic, apoptotic, and necroptotic programs in macrophages, thereby driving inflammatory injury and multiorgan damage during sepsis. Abstract Mounting evidence indicates that macrophage PANoptosis—an integrated inflammatory cell‐death program comprising pyroptosis, apoptosis ...
Xia Y, Yao RQ, Liu HF, Jing GQ, Aidebaike D, Zuo J, Wan SQ, Wu D, Zhao PY, Gong HL, Wang X, Zhou HM, Dong N, Wu Y, Liu S, Wu XJ, Yao YM, Song XM.   +17 more
europepmc   +2 more sources

RIPK1 S213E mutant suppresses RIPK1-dependent cell death by preventing interactions with RIPK3 and CASP8

Cell Death Discovery
RIPK1 (Receptor-interacting serine/threonine-protein kinase 1) is fundamental in regulating cell proliferation, programmed cell death, and inflammation.
Ning Nan, Hong Hu, Xinxin Zhu, Jia Liu, Feiyang Yuan, Zhijie Li, Huayi Wang   +6 more
doaj   +2 more sources

IAPs: Guardians of RIPK1 [PDF]

Cell Death & Differentiation, 2011
Deregulation of innate immune signalling and cell death form the basis of most human disease pathogenesis. Inhibitor of APoptosis (IAP) protein-family members are frequently overexpressed in cancer and contribute to tumour cell survival, chemo-resistance, disease progression and poor prognosis. Although best known for their ability to regulate caspases,
M, Darding, P, Meier
openaire   +2 more sources

Advances in RIPK1 kinase inhibitors

Frontiers in Pharmacology, 2022
Programmed necrosis is a new modulated cell death mode with necrotizing morphological characteristics. Receptor interacting protein 1 (RIPK1) is a critical mediator of the programmed necrosis pathway that is involved in stroke, myocardial infarction, fatal systemic inflammatory response syndrome, Alzheimer’s disease, and malignancy.
Lu Chen, Lu Chen, Xiaoqin Zhang, Yaqing Ou, Maoyu Liu, Maoyu Liu, Dongke Yu, Dongke Yu, Zhiheng Song, Lihong Niu, Lijuan Zhang, Lijuan Zhang, Jianyou Shi, Jianyou Shi   +13 more
openaire   +3 more sources

The double life of RIPK1 [PDF]

Molecular & Cellular Oncology, 2015
We have recently identified receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) as an oncogenic driver in melanoma in addition to its well-established role in controlling cell survival and death. Our studies show that RIPK1 promotes melanoma cell proliferation through a positive feedback loop of NFKB1-BIRC2/BIRC3-RIPK1 powered by autocrine ...
Jin, Lei, Chen, Jiezhong, Liu, Xiao Ying, Jiang, Chen Chen, Zhang, Xu Dong   +4 more
openaire   +2 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance While the critical role of RIPK1 kinase activity in mediating necroptosis and RIPK1-dependent apoptosis has been established, we still know little about how the nonkinase domains of RIPK1 regulate its kinase activity. Establishing the role of RIPK1-death domain (DD) in mediating RIPK1 activation and formation of complex ...
Huyan Meng, Zhen Liu, Xingyan Li, Huibing Wang, Taijie Jin, Guowei Wu, Bing Shan, Dana E. Christofferson, Chunting Qi, Qiang Yu, Ying Li, Junying Yuan   +11 more
openaire   +2 more sources

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source