Results 21 to 30 of about 18,020 (210)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

RIPK1 prevents aberrant ZBP1-initiated necroptosis [PDF]

Oncotarget, 2016
Kaiser, William J, Vanden Berghe, Tom
core   +4 more sources

Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]

, 2012
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Barna, Gabor, Bauer, Pal I., Dunai, Zsuzsanna A., Imre, Gergely, Korcsmaros, Tamas, Mihalik, Rudolf, Petak, Istvan   +6 more
core   +9 more sources

The phospho-barcode of RIPK1: complementarity or redundancy?

Molecular & Cellular Oncology, 2020
Receptor interacting serine/threonine kinase 1 (RIPK1) is the central mediator of tumor necrosis factor (TNF) signaling. It regulates both pro-survival/pro-inflammatory and cell death pathways.
Wenxian Wu, Björn Stork
doaj   +1 more source

O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosis

Frontiers in Immunology, 2023
Necroptosis is a type of cell death with excessive inflammation and organ damage in various human diseases. Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O ...
Junghwa Seo, Yeolhoe Kim, Yeolhoe Kim, Suena Ji, Han Byeol Kim, Hyeryeon Jung, Hyeryeon Jung, Eugene C. Yi, Eugene C. Yi, Yong-ho Lee, Yong-ho Lee, Injae Shin, Injae Shin, Won Ho Yang, Won Ho Yang, Jin Won Cho, Jin Won Cho   +16 more
doaj   +1 more source

Changes in Expression of Receptor-Interacting Protein Kinase 1 in Secondary Neural Tissue Damage Following Spinal Cord Injury

Neuroscience Insights, 2020
Introduction: Necroptosis is a form of programmed cell death that is different from apoptotic cell death. Receptor-interacting protein kinase 1 (RIPK1) plays a particularly important function in necroptosis execution.
Haruo Kanno, Hiroshi Ozawa, Kyoichi Handa, Taishi Murakami, Eiji Itoi   +4 more
doaj   +1 more source

RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts

Cell Death and Disease, 2022
Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are critical regulators of programmed necrosis or necroptosis. However, the role of the RIPK1/RIPK3 signaling pathway in myocardial fibrosis and related diabetic cardiomyopathy is still unclear.
Shigang Qiao, Lei Hong, Yongming Zhu, Jun Zha, An Wang, Jia Qiu, Wei Li, Chen Wang, Jianzhong An, Huiling Zhang   +9 more
doaj   +1 more source

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis [PDF]

Nature Communications, 2019
AbstractThe ubiquitination status of RIPK1 is considered to be critical for cell fate determination. However, the in vivo role for RIPK1 ubiquitination remains undefined. Here we show that mice expressing RIPK1K376R which is defective in RIPK1 ubiquitination die during embryogenesis.
Xixi Zhang, Haiwei Zhang, Chengxian Xu, Xiaoming Li, Ming Li, Xiaoxia Wu, Wenjuan Pu, Bin Zhou, Haikun Wang, Dali Li, Qiurong Ding, Hao Ying, Hui Wang, Haibing Zhang   +13 more
openaire   +3 more sources

MLKL Regulates Rapid Cell Death-independent HMGB1 Release in RSV Infected Airway Epithelial Cells

Frontiers in Cell and Developmental Biology, 2022
Respiratory syncytial virus (RSV)-induced bronchiolitis is a significant contributor to infant morbidity and mortality. Previously, we identified that necroptosis, a pro-inflammatory form of cell death mediated by receptor-interacting serine/threonine ...
Jennifer Simpson, Jennifer Simpson, Kirsten M. Spann, Simon Phipps, Simon Phipps, Simon Phipps   +5 more
doaj   +1 more source

Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis. [PDF]

, 2018
Understanding the molecular signaling in programmed cell death is vital to a practical understanding of inflammation and immune cell function. Here we identify a previously unrecognized mechanism that functions to downregulate the necrosome, a central ...
A Degterev, A Degterev, A Kaczmarek, A Polykratis, B Shutinoski, C Fearns, CP Dillon, D Ofengeim, DE Christofferson, DM Monack, DM Moquin, DR Green, EW Harhaj, F Ginhoux, G Dougan, H Sakamoto, I Jaco, J Hitomi, JW Upton, K Newton, KE Lawlor, L Duprez, L Eckmann, L Galluzzi, LA O’Neill, M Belosevic, M Pasparakis, MA Brennan, MJ Bertrand, N Arpaia, N Bidere, N Festjens, N Robinson, N Shembade, N Takahashi, N Vanlangenakker, N. Peltzer, P Mandal, P Vandenabeele, P Vandenabeele, R Bellamy, R Patel, RE Voll, S Akira, S He, S He, S Malladi, S McComb, S McComb, S McComb, S McComb, SB Berger, SC Sun, SP Salcedo, ST Beug, T McQuade, T Vanden Berghe, T Xie, TH Chuang, W Declercq, W Reiley, WD Cook, WJ Kaiser, WW Reiley, XN Wu, Y Dondelinger, YS Cho, Z Cai   +67 more
core   +2 more sources