Results 51 to 60 of about 753,590 (330)
mRNA Regulation by RNA Modifications
Annual Review of Biochemistry, 2023 Chemical modifications on mRNA represent a critical layer of gene expression regulation. Research in this area has continued to accelerate over the last decade, as more modifications are being characterized with increasing depth and breadth. mRNA modifications have been demonstrated to influence nearly every step from the early phases of transcript ...
Gilbert, Wendy V., Nachtergaele, Sigrid
openaire +2 more sources
PROBer Provides a General Toolkit for Analyzing Sequencing-Based Toeprinting Assays [PDF]
, 2017 A number of sequencing-based transcriptase drop-off assays have recently been developed to probe post-transcriptional dynamics of RNA-protein interaction, RNA structure, and RNA modification.
Aviran, Sharon +3 more
core +2 more sources
AIMS BioengineeringN6,2′-O-dimethyladenosine (m6Am) is a crucial RNA modification that plays a pivotal role in regulating gene expression and maintaining RNA stability. Given its dynamic involvement in various biological processes and diseases, accurately identifying m6Am ...
Islam Uddin +3 more
doaj +1 more source
Characterization of N6-methyladenosine long non-coding RNAs in sporadic congenital cataract and age-related cataract [PDF]
International Journal of OphthalmologyAIM: To characterize the N6-methyladenosine (m6A) modification patterns in long non-coding RNAs (lncRNAs) in sporadic congenital cataract (CC) and age-related cataract (ARC).
Hong-Fei Ye +10 more
doaj +1 more source
Frontiers in Insect ScienceMore than 100 RNA chemical modifications to cellular RNA have been identified. N6-methyladenosine (m6A) is the most prevalent modification of mRNA. RNA modifications have recently attracted significant attention due to their critical role in regulating mRNA processing and metabolism.
Yaoyu Jiao +2 more
openaire +3 more sources
International Journal of General Medicine, 2022 Xuebao Xiang, Yi Guo, Zhongyuan Chen, Zengnan Mo Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical ...
Xiang X, Guo Y, Chen Z, Mo Z
doaj
Multiple Functions of RNA Methylation in T Cells: A Review
Frontiers in Immunology, 2021 RNA modification represents one of the most ubiquitous mechanisms of epigenetic regulation and plays an essential role in modulating cell proliferation, differentiation, fate determination, and other biological activities.
Yinong Chao +5 more
doaj +1 more source
Chemical methods for the modification of RNA
Methods, 2019 RNA is often considered as being the vector for the transmission of genetic information from DNA to the protein synthesis machinery. However, besides translation RNA participates in a broad variety of fundamental biological roles such as gene expression and regulation, protein synthesis, and even catalysis of chemical reactions.
Marie Flamme +3 more
openaire +4 more sources
Cellular Dynamics of RNA Modification [PDF]
Accounts of Chemical Research, 2011 Five decades of research have identified more than 100 ribonucleosides that are post-transcriptionally modified. Many modified nucleosides are conserved throughout bacteria, archaea, and eukaryotes, while some are unique to each branch of life. However, the cellular and functional dynamics of RNA modification remain largely unexplored, mostly because ...
Tao Pan, Chengqi Yi
openaire +3 more sources
Increased levels of RNA oxidation enhance the reversion frequency in aging pro-apoptotic yeast mutants [PDF]
, 2016 Despite recent advances in understanding the complexity of RNA processes, regulation of the metabolism of oxidized cellular RNAs and the mechanisms through which oxidized ribonucleotides affect mRNA translation, and consequently cell viability, are not ...
A Nunomura +36 more
core +2 more sources