Results 51 to 60 of about 323,185 (236)
Non-mammalian model organisms in epigenetic research : an overview [PDF]
, 2020 Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik +3 more
core +2 more sources
Cellular Dynamics of RNA Modification [PDF]
Accounts of Chemical Research, 2011 Five decades of research have identified more than 100 ribonucleosides that are post-transcriptionally modified. Many modified nucleosides are conserved throughout bacteria, archaea, and eukaryotes, while some are unique to each branch of life. However, the cellular and functional dynamics of RNA modification remain largely unexplored, mostly because ...
Chengqi, Yi, Tao, Pan
openaire +2 more sources
Research Progress on Epigenetic Regulation of Fungal Secondary Metabolism
Guangdong nongye kexueFungi are capable of synthesizing a wide array of secondary metabolites with diverse structures and biological activities, which have significant applications in agriculture, medicine, food, and industry.
Siyi TAN +3 more
doaj +1 more source
Cfp1 is required for gene expression dependent H3K4me3 and H3K9 acetylation in embryonic stem cells [PDF]
, 2014 BackgroundTrimethylation of histone H3 lysine 4 (H3K4me3) accumulates at promoters in a gene activity dependent manner. The Set1 complex is responsible for most H3K4me3 in somatic cells and contains the conserved subunit Cfp1, which is implicated in ...
Bird, Adrian +2 more
core +1 more source
RNA 5-Methylcytosine Modification in Myocardial Fibrosis
Reviews in Cardiovascular MedicineMyocardial fibrosis represents a common pathological hallmark of various cardiovascular diseases progressing to heart failure, with the immunoinflammatory response playing a pivotal role in the pathogenesis of myocardial fibrosis.
Bohan Li, Yan Hao, Wendan Tian, Wei Liu
doaj +1 more source
International Journal of General Medicine, 2022 Xuebao Xiang, Yi Guo, Zhongyuan Chen, Zengnan Mo Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical ...
Xiang X, Guo Y, Chen Z, Mo Z
doaj
mRNA Regulation by RNA Modifications
Annual Review of Biochemistry, 2023 Chemical modifications on mRNA represent a critical layer of gene expression regulation. Research in this area has continued to accelerate over the last decade, as more modifications are being characterized with increasing depth and breadth. mRNA modifications have been demonstrated to influence nearly every step from the early phases of transcript ...
Gilbert, Wendy V., Nachtergaele, Sigrid
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
HiTRACE-Web: an online tool for robust analysis of high-throughput capillary electrophoresis [PDF]
, 2013 To facilitate the analysis of large-scale high-throughput capillary electrophoresis data, we previously proposed a suite of efficient analysis software named HiTRACE (High Throughput Robust Analysis of Capillary Electrophoresis).
Cordero, Pablo +3 more
core +2 more sources
Small RNA modifications in Alzheimer’s disease [PDF]
Neurobiology of Disease, 2020 AbstractBackgroundWhile significant advances have been made in uncovering the aetiology of Alzheimer’s disease and related dementias at the genetic level, molecular events at the epigenetic level remain largely undefined. Emerging evidence indicates that small non-coding RNAs (sncRNAs) and their associated RNA modifications are important regulators of ...
Xudong Zhang +7 more
openaire +5 more sources