RNA modifications in insects [PDF]
Frontiers in Insect ScienceMore than 100 RNA chemical modifications to cellular RNA have been identified. N6-methyladenosine (m6A) is the most prevalent modification of mRNA. RNA modifications have recently attracted significant attention due to their critical role in regulating ...
Yaoyu Jiao +2 more
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RNA modifications in cancer [PDF]
MedCommRNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such as N6‐methyladenosine (m6A) and 5‐methylcytosine (m5C), are implicated in various cellular processes.
Han Wu +11 more
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RNA Modifications in Health and Disease [PDF]
MedCommRNA modifications, including N6‐methyladenosine (m6A), 5‐methylcytosine, and pseudouridine, serve as pivotal regulators of gene expression with significant implications for human health and disease.
Shiqi Li +5 more
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Immunomodulatory role of RNA modifications in sex hormone-dependent cancers [PDF]
Frontiers in ImmunologyRecent studies have identified that RNA epigenetic modifications, including m6A, m1A, m5C, etc, play pivotal roles in tumor progression. These modifications influence mRNA stability, RNA processing, translational efficiency, and decoding precision ...
Yujia Jiang +5 more
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Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing [PDF]
Advanced GeneticsRNA modifications add a dynamic and versatile regulatory layer to gene expression, influencing RNA stability, splicing, translation, and cellular responses.
Yaran Liu, Yang Li, Qiang Sun
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RNA modifications in the tumor microenvironment: insights into the cancer-immunity cycle and beyond [PDF]
Experimental Hematology & OncologyThe chemical modification of biological molecules is a critical regulatory mechanism for controlling molecular functions. Although research has long focused on DNA and proteins, RNA modifications have recently attracted substantial interest with the ...
You-Peng Ding, Cui-Cui Liu, Ke-Da Yu
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Mitochondria at the intersections of RNA modifications and metabolism reprogramming implications in cell death, tumor microenvironment, and immunotherapy [PDF]
Journal of Hematology & OncologyMitochondria, the powerhouse of the cell, orchestrate a plethora of critical functions, including energy production, metabolic regulation, programmed cell death, and signal transduction.
Jiaxun Zhang +11 more
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Rationalizing the effects of RNA modifications on protein interactions [PDF]
Molecular Therapy: Nucleic AcidsRNA modifications play a crucial role in regulating gene expression by altering RNA structure and modulating interactions with RNA-binding proteins (RBPs).
Andrea Vandelli +4 more
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RNA modifications: emerging players in the regulation of reproduction and development [PDF]
Acta Biochimica et Biophysica SinicaThe intricate world of RNA modifications, collectively termed the epitranscriptome, covers over 170 identified modifications and impacts RNA metabolism and, consequently, almost all biological processes.
Wen Junfei +3 more
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Hydroxychloroquine Modulates m6A RNA Methylation in Prostate Cancer Cells
Cumhuriyet Science Journal, 2023 Prostate cancer ranks as the second most prevalent cancer in men globally. One of the evolving subjects of investigation in prostate cancer is the role of N6-methyladenosine (m6A) modifications. Hydroxychloroquine (HCQ), an autophagy inhibitor, was shown
Merve Gülsen Bal Albayrak, Sevinc Yanar
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