Results 21 to 30 of about 774,970 (276)
An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization
Cells, 2019 Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast +2 more
doaj +1 more source
RNA modifications detection by comparative Nanopore direct RNA sequencing
Nature Communications, 2021 Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data.
Adrien Leger +18 more
doaj +1 more source
RNA modifications can affect RNase H1-mediated PS-ASO activity
Molecular Therapy: Nucleic Acids, 2022 Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage by RNase H1.
Katelyn A. Doxtader Lacy +3 more
doaj +1 more source
Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA [PDF]
, 2012 Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H ...
Entian, Karl-Dieter +5 more
core +1 more source
Detection of RNA modifications [PDF]
RNA Biology, 2010 RNA nucleotide modifications are typically of low abundance and frequently go unnoticed by standard detection methods of molecular biology and cell biology. With a burst of knowledge intruding from such diverse areas as genomics, structural biology, regulation of gene expression and immunology, it becomes increasingly clear that many exciting functions
Stefanie, Kellner +2 more
openaire +2 more sources
Uridylation and adenylation of RNAs. [PDF]
, 2015 The posttranscriptional addition of nontemplated nucleotides to the 3' ends of RNA molecules can have a significant impact on their stability and biological function.
Chen, XueMei +3 more
core +2 more sources
Direct detection of RNA modifications and structure using single-molecule nanopore sequencing
Cell Genomics, 2022 Summary: Modifications are present on many classes of RNA, including tRNA, rRNA, and mRNA. These modifications modulate diverse biological processes such as genetic recoding and mRNA export and folding. In addition, modifications can be introduced to RNA
William Stephenson +5 more
doaj +1 more source
Post-Transcriptional Regulation of Viral RNA through Epitranscriptional Modification
Cells, 2021 The field of mRNA modifications has been steadily growing in recent years as technologies have improved and the importance of these residues became clear.
David G. Courtney
doaj +1 more source
Deciphering the epitranscriptome: a green perspective [PDF]
, 2016 The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation - the epitranscriptome.
Burgess, A., David, R., Searle, I.
core +1 more source
RNA modification mapping with JACUSA2
Genome Biology, 2022 Abstract Several high-throughput antibody-free methods for RNA modification detection from sequencing data have been developed. We present JACUSA2 as a versatile software solution and comprehensive analysis framework for RNA modification detection assays that are based on either the Illumina or Nanopore platform ...
Michael Piechotta +4 more
openaire +4 more sources