Results 41 to 50 of about 774,970 (276)

Detection technologies for RNA modifications

Experimental & Molecular Medicine, 2022
AbstractTo date, more than 170 chemical modifications have been characterized in RNA, providing a new layer of gene expression regulation termed the ‘epitranscriptome’. RNA modification detection methods and tools advance the functional studies of the epitranscriptome.
Zhang, Yan, Lu, Liang, Li, Xiaoyu
openaire   +2 more sources

Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms [PDF]

, 2011
Understanding the genesis of the block haplotype structure of the genome is a major challenge. With the completion of the sequencing of the Human Genome and the initiation of the HapMap project the concept that the chromosomes of the mammalian genome are
Carnegie, P., Dawkins, R.L., Lester, S., Lindley, R.A., Millman, J.A., Pain, G.N., Steele, E.J., Stewart, B.J., Williamson, J.F.   +8 more
core   +2 more sources

Positioning Europe for the EPITRANSCRIPTOMICS challenge [PDF]

, 2018
The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built.
Almeida, Raquel, Ameres, Stefan, Ayers, Duncan, Balatsos, Nikolaos, Ballana, Ester, Bankovic, Jasna, Banovic, Bojana, Baranov, Pavel, Bousquet-Antonelli, Cecile, Bujnicki, Janusz, Cardona, Fernando, Carre, Clement, Costache, Marieta, Cowling, Victoria, Dahl, John Arne, Davalos, Alberto, David, Alexandre, Demircan, Turan, Dinnyes, Andras, Drablos, Finn, Fray, Rupert, Frye, Michaela, Fuks, Francois, Helm, Mark, Holodnuka Kholodnyuk, Irina, Jantsch, Michael, Jeronimo, Carmen, Kelly, Vincent, Klungland, Arne, Kyselovic, Jan, Lafontaine, Denis, Lamm, Ayelet, Liepins, Janis, Lyko, Frank, Macias-Gonzales, Manuel, Motorin, Yuri, Neagu, Monica, Nielsen, Henrik, O Carroll, Donal, O'Connell, Mary, Ohman, Marie, Oulas, Anastasis, Pelizzola, Mattia, Pir, Pinar, Purta, Elzbieta, Quattrone, Alessandro, Rechavi, Gideon, Roignant, Jean-Yves, Rossmanith, Walter, Schaffrath, Raffael, Schwartz, Schraga, Schäfer, Matthias, Selbert, Stefan, Timotijevic, Gordana, Ule, Jernej, Valor, Luis Miguel, Vanacova, Stepanka, Verdel, Andre, Willems, Luc, Zammit, Vanessa   +59 more
core   +13 more sources

Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma

Frontiers in Pharmacology, 2021
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood.
Xing-xing Huo, Xing-xing Huo, Shu-jie Wang, Hang Song, Ming-de Li, Hua Yu, Meng Wang, Hong-xiao Gong, Xiao-ting Qiu, Yong-fu Zhu, Jian-ye Zhang   +10 more
doaj   +1 more source

The impact of RNA modifications on the biology of DNA virus infection

European Journal of Cell Biology, 2022
Approximately 170 RNA modifications have been identified and these are critical for determining the fate and function of cellular RNAs. Similar to human transcripts, viral RNAs possess an extensive RNA modification landscape.
Suba Rajendren, John Karijolich
doaj   +1 more source

High-throughput, Efficient, and Unbiased Capture of Small RNAs from Low-input Samples for Sequencing. [PDF]

, 2019
MicroRNAs hold great promise as biomarkers of disease. However, there are few efficient and robust methods for measuring microRNAs from low input samples.
Belair, Cassandra D, Blelloch, Robert H, Chu, Brandon, Cooperberg, Matthew R, Freimer, Jacob W, Hu, Tianyi   +5 more
core   +2 more sources

Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit. [PDF]

, 2020
Post-transcriptional ribosomal RNA (rRNA) modifications are present in all organisms, but their exact functional roles and positions are yet to be fully characterized.
Fraser, James S, Frost, Adam, Fujimori, Danica Galonić, Myasnikov, Alexander G, Stojković, Vanja, Young, Iris D   +5 more
core  

Cfp1 is required for gene expression dependent H3K4me3 and H3K9 acetylation in embryonic stem cells [PDF]

, 2014
BackgroundTrimethylation of histone H3 lysine 4 (H3K4me3) accumulates at promoters in a gene activity dependent manner. The Set1 complex is responsible for most H3K4me3 in somatic cells and contains the conserved subunit Cfp1, which is implicated in ...
Bird, Adrian, Clouaire, Thomas, Webb, Shaun   +2 more
core   +1 more source

SnapShot: Messenger RNA Modifications

Cell, 2018
mRNA modifications are defining a novel layer of complexity that is becoming widely appreciated as the epitranscriptome. This SnapShot summarizes the major breakthroughs in the burgeoning field of mRNA modifications to provide an overview of the molecular players involved and insights gained into the functional consequences of the growing number of ...
Veronica, Davalos, Sandra, Blanco, Manel, Esteller   +2 more
openaire   +2 more sources

The potential regulatory role of RNA methylation in ovarian cancer

RNA Biology, 2023
Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao, Mengxue Zhang, Xiaolan Zhu, Jie Xing, Jiaming Zhou, Xinming Yin   +5 more
doaj   +1 more source