RNA Modification and Its Implication in Plant Pathogenic Fungi [PDF]
The Plant Pathology Journal, 2021 Interaction of a pathogen with its host plant requires both flexibility and rapid shift in gene expression programs in response to environmental cues associated with host cells. Recently, a growing volume of data on the diversity and ubiquity of internal
Junhyun Jeon, Song Hee Lee
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Polymorphism identification and improved genome annotation of Brassica rapa through Deep RNA sequencing. [PDF]
, 2014 The mapping and functional analysis of quantitative traits in Brassica rapa can be greatly improved with the availability of physically positioned, gene-based genetic markers and accurate genome annotation.
Covington, Michael F +4 more
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Chemical Modifications of Ribosomal RNA
, 2022 AbstractCellular RNAs in all three kingdoms of life are modified with diverse chemical modifications. These chemical modifications expand the topological repertoire of RNAs, and fine-tune their functions. Ribosomal RNA in yeast contains more than 100 chemically modified residues in the functionally crucial and evolutionary conserved regions.
Sunny, Sharma, Karl-Dieter, Entian
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Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications. [PDF]
, 2016 Non-coding RNAs are crucial regulators for a vast array of cellular processes and have been implicated in human disease. These biological processes represent a hitherto untapped resource in our fight against disease.
Amy Cording (1383558) +6 more
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Regulatory RNAs: role as scaffolds assembling protein complexes and their epigenetic deregulation
Exploration of Targeted Anti-tumor TherapyRecently, new data have been added to the interaction between non-coding RNAs (ncRNAs) and epigenetic machinery. Epigenetics includes enzymes involved in DNA methylation, histone modifications, and RNA modifications, and mechanisms underlying chromatin ...
Palmiro Poltronieri
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Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. [PDF]
, 2010 Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes.
Alekseyenko, Artyom A +29 more
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Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 [PDF]
, 2011 The 5'-cap-structures of higher eukaryote mRNAs are ribose 2'-O-methylated. Likewise, a number of viruses replicating in the cytoplasm of eukayotes have evolved 2'-O-methyltransferases to modify autonomously their mRNAs.
A Ghosh +55 more
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Nanopore-Based Detection of Viral RNA Modifications
mBio, 2022 The chemical modification of ribonucleotides plays an integral role in the biology of diverse viruses and their eukaryotic host cells. Mapping the precise identity, location, and abundance of modified ribonucleotides remains a key goal of many studies ...
Jonathan S. Abebe +2 more
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Cellular Dynamics of RNA Modification [PDF]
Accounts of Chemical Research, 2011 Five decades of research have identified more than 100 ribonucleosides that are post-transcriptionally modified. Many modified nucleosides are conserved throughout bacteria, archaea, and eukaryotes, while some are unique to each branch of life. However, the cellular and functional dynamics of RNA modification remain largely unexplored, mostly because ...
Chengqi, Yi, Tao, Pan
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The regulation of antiviral innate immunity through non-m6A RNA modifications
Frontiers in Immunology, 2023 The post-transcriptional RNA modifications impact the dynamic regulation of gene expression in diverse biological and physiological processes. Host RNA modifications play an indispensable role in regulating innate immune responses against virus infection
Shenghai Shen +2 more
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