Results 1 to 10 of about 29,788 (255)
Oral microbiome-SASP-aging axis: mechanisms and targeted intervention strategies for age-related diseases [PDF]
Journal of Oral MicrobiologyBackground Global demographic aging is intensifying the burden of age-related diseases. Cellular senescence and the accompanying senescence-associated secretory phenotype (SASP) act as key drivers of disease progression by mediating chronic inflammation.
Enfang Wu +4 more
doaj +2 more sources
Analysis of molecular subtypes and prognostic signature of senescence-associated secretory phenotype in pancreatic cancer [PDF]
PeerJBackground Pancreatic cancer (PC) exhibits an extremely poor prognosis due to its high heterogeneity. The senescence-associated secretory phenotype (SASP), a distinct secretory profile displayed by senescent cells, has been increasingly studied. However,
Yuewen Kuang +3 more
doaj +3 more sources
Cationic local composition fluctuations in rapidly cooled nuclear fuel melts
Nuclear Materials and Energy, 2022 During a severe accident in a nuclear reactor, as it occurred in Fukushima Daiichi BWRs in 2011, the so-called “corium” resulting from the thermal fusion of nuclear fuel and interaction with the zircaloy cladding at high temperature (T > 2800 K) can be ...
Mohamed Jizzini +4 more
doaj +1 more source
Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay. [PDF]
PLoS ONE, 2012 Senescence-associated secretory phenotype (SASP) is characterized by abundant secretion of various proteins in senescent cells and implicated in tumor progression and inflammatory responses.
Liubao Gu, Masanori Kitamura
doaj +1 more source
The Histone Code of Senescence
Cells, 2020 Senescence is the end point of a complex cellular response that proceeds through a set of highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes senescence is a pro-survival response to irreparable DNA damage.
Harikrishnareddy Paluvai +2 more
doaj +1 more source
Phenomenology and Mind, 2017 There is a prevalent tension within recent cognitive scientific accounts of human selfhood in that either bodily processes or social processes are explanatorily favored at the expense of the other.
Joe Higgins
doaj +1 more source
Erciyes Medical Journal, 2019 Objective: In the present study we aim to evaluate whether some of the proteins previously identified in the secretome of senescent bone marrow (BM)- and adipose (A)-mesenchymal stromal cells (MSCs) could be involved in regulation of senescence phenomena.
Tiziana Squillaro +7 more
doaj +1 more source
Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities
Gut Microbes, 2020 Probiotic bacteria are increasingly gaining importance in human nutrition owing to their multifaceted health beneficial effects. Studies have also shown that probiotic supplementation is useful in mitigating age-associated oxi-inflammatory stress ...
Rohit Sharma, Yogendra Padwad
doaj +1 more source
Cells, 2020 Immunosenescence in monocytes has been shown to be associated with several biochemical and functional changes, including development of senescence-associated secretory phenotype (SASP), which may be inhibited by klotho protein.
Jennifer Mytych +6 more
doaj +1 more source
Senescence-associated secretory phenotype and its impact on oral immune homeostasis
Frontiers in Immunology, 2022 The senescence-associated secretory phenotype (SASP), which accumulates over the course of normal aging and in age-related diseases, is a crucial driver of chronic inflammation and aging phenotypes. It is also responsible for the pathogenesis of multiple
Ziqi Yue +12 more
doaj +1 more source