Results 171 to 180 of about 29,788 (255)

Late Depression and Senescence-Associated Secretory Phenotype (SASP)

European Psychiatry
IntroductionNeurobiological mechanisms of late depression include abnormal regulation and interaction of multiple biological processes, as well as abnormalities of brain structures and organs.Objectivesliterature analysisMethodsgeneral scientific methodResultsThe results of the study show that the SASP index as an integral indicator of changes in ...
openaire   +1 more source

P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
P2X7R regulates the nucleoplasmic translocation of HuR, thereby enhancing the stability of the E3 ubiquitin ligase TRIM26. TRIM26 directly binds to NR4A1 and promotes its ubiquitination, thereby suppressing mitophagy and increasing reactive oxygen species (ROS) production.
Yixin Zhou, Xin Zhong, Zhijie Mao, Yunxuan Chen, Jincheng Xing, Jiaxu Shen, Wenli Zhang, Ji Zhang, Jiaxuan Mei, Zhentong Yang, Zhuoqun Wang, Bozhi Ye, Jiahui Lin, Yonghua Wang, Zhouqing Huang   +14 more
wiley   +1 more source

Bioactive Phytochemical Compounds in Medicago sativa L. (Alfalfa): A Systematic Review of Biological Properties and Therapeutic Relevance in Nutraceutical and Functional Food Implications

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani, Hamid Rashidi Nodeh, Zahra Esfandiari, Giovanna Ferrentino   +3 more
wiley   +1 more source

The paradox of cellular senescence in prostate cancer: from tumor suppression to tumor promotion. [PDF]

Front Oncol
Xing Y, Qin G, Lin X, Chen S, Su Y, Lin T, Chen G.   +6 more
europepmc   +1 more source

Senescence utilises inflammatory caspases to drive SASP

Aging, 2019
Wiggins, Kimberley A, Clarke, Murray Ch
openaire   +3 more sources

Ginsenoside Rb1 Targets the HRD1‐STING Axis to Mitigate Cholesterol‐Induced VSMC Senescence

Journal of Clinical Laboratory Analysis, Volume 40, Issue 5, March 2026.
Schematic representation of the proposed mechanism of action for Ginsenoside Rb1. Suppression of HRD1 expression in VSMCs cholesterol stimulation, leading to ER stress (BiP/XBP1s upregulation), STING pathway activation, ROS accumulation (including mitochondrial ROS), and ultimately, VSMC senescence.
Haiming Niu, Yingzhang Cai, Conghui Yu, Ning Lin, Miaolian Chen, Linli Wang   +5 more
wiley   +1 more source

Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP). IV. Pharmacokinetics of SASP in the rat following consecutive oral doses.

Drug Metabolism and Pharmacokinetics, 1991
Birgitta SJÖQUIST, Nils-Otto AHNFELT, Stig ANDERSSON, Roland d'ARGY, Masanori HATSUOKA, Tetsuya SUGA, Takafumi WATANABE, Ingrid LJUNGSTEDT-PÅHLMAN   +7 more
openaire   +2 more sources

Translational Pathways for Smart and Bioactive Dental Biomaterials: Biocompatibility Standards, Sterilisation, Sustainability and Regulation

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
Smart and bioactive dental biomaterials can do more than replace tissue, but getting them into the clinic requires more than promising lab results. This review brings together practical requirements for translation, covering ISO‐based biocompatibility planning, low‐temperature sterilisation for sensitive materials, life‐cycle assessment for ...
Katarzyna Chojnacka, Marcin Mikulewicz
wiley   +1 more source

ANT1 and the SASP: Beyond the Bioenergetic Void

American Journal of Respiratory Cell and Molecular Biology, 2023
openaire   +2 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source