Results 11 to 20 of about 29,788 (255)
SASP – Physiotherapy beyond 100 years of rehabilitation
South African Journal of PhysiotherapyNo abstract ...
Witness Mudzi
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Mitochondrial RNA cytosolic leakage drives the SASP
Nature CommunicationsSenescent cells secrete proinflammatory factors known as the senescence-associated secretory phenotype (SASP), contributing to tissue dysfunction and aging. Mitochondrial dysfunction is a key feature of senescence, influencing SASP via mitochondrial DNA (
Stella Victorelli +22 more
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SASP reflects senescence [PDF]
EMBO reports, 2009 Senescence is a permanent state of cell cycle arrest that—unlike quiescence—is unresponsive to growth factors. Originally described in terms of the replicative exhaustion of cultured fibroblasts (Hayflick & Moorhead, 1961), it has since been shown that senescence can occur prematurely upon oncogene induction and other cellular stresses.
Andrew R J, Young, Masashi, Narita
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Calcified Tissue International, 2023 AbstractSenescence is a complex cell state characterized by stable cell cycle arrest and a unique secretory pattern known as the senescence-associated secretory phenotype (SASP). The SASP factors, which are heterogeneous and tissue specific, normally include chemokines, cytokines, growth factors, adhesion molecules, and lipid components that can lead ...
Fang, Ching-Lien, Liu, Bin, Wan, Mei
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TORn about SASP regulation [PDF]
Cell Cycle, 2015 Senescence is a cellular response to stresses such as oncogenic signaling, DNA damage and telomere loss, characterized by a stable growth arrest.
Nicolás, Herranz +2 more
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SASP regulation by noncoding RNA [PDF]
Mechanisms of Ageing and Development, 2017 Noncoding RNAs (ncRNAs), including micro (mi)RNAs, long noncoding (lnc)RNAs, and circular (circ)RNAs, control specific gene expression programs by regulating transcriptional, post-transcriptional, and post-translational processes. Through their broad influence on protein expression and function, ncRNAs have been implicated in virtually all cellular ...
Amaresh C, Panda +2 more
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A proteomic atlas of senescence-associated secretomes for aging biomarker development. [PDF]
, 2020 The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.
Basisty, Nathan +11 more
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SIN3B, the SASP, and pancreatic cancer [PDF]
Molecular & Cellular Oncology, 2014 Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell cycle, senescent cells secrete inflammatory factors. We recently demonstrated that senescence correlates with accelerated cancer progression in a mouse model of pancreatic ductal adenocarcinoma.
Cantor, David J, David, Gregory
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Senescence and the SASP: many therapeutic avenues [PDF]
Genes & Development, 2020 Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). Acute senescence induction protects against cancer and limits fibrosis, but lingering senescent cells drive age-
Birch, J, Gil, J
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Defective mitochondria ignite the SASP [PDF]
Nature Reviews Molecular Cell Biology, 2020 Defective mitochondria in senescent cells activate a signalling pathway that promotes the senescence-associated secretory phenotype and inflammation.
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