The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
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Secondary amine selective Petasis (SASP) bioconjugation
Chemical Science, 2020 Secondary amine selective Petasis (SASP) bioconjugation for the selective labeling of peptides and proteins with N-terminal secondary amines.
Yonnette E. Sim +5 more
openaire +3 more sources
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]
, 2020 The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda +9 more
core +1 more source
Epiregulation of the SASP makes good neighbors
Nature Aging, 2021 The tumor microenvironment (TME) impacts different phases of tumor progression and therapy resistance. Zhang et al. show that senescent stromal cells activate an epigenetic program that controls the senescence-associated secretory phenotype and can be targeted to boost responses to chemotherapy.
Desbats, Maria Andrea +2 more
openaire +3 more sources
Dissecting cellular senescence and SASP in Drosophila [PDF]
Inflammation and Regeneration, 2016 Cellular senescence can act as both tumor suppressor and tumor promoter depending on the cellular contexts. On one hand, premature senescence has been considered as an innate host defense mechanism against carcinogenesis in mammals. In response to various stresses including oxidative stress, DNA damage, and oncogenic stress, suffered cells undergo ...
Ito, Takao, Igaki, Tatsushi
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Controlling secretion to limit chemoresistance [PDF]
, 2016 The tumor microenvironment influences cancer progression and therapy outcome by mechanisms not yet fully understood. In this issue, Bent et al. (2016) show how chemotherapy causes endothelial senescence.
Georgilis, A, Gil, J
core +1 more source
NOTCH and the 2 SASPs of senescence [PDF]
Cell Cycle, 2016 The previous view that cellular senescence represented a stress-responsive tumor suppressor mechanism has been significantly revised recently with recognition of the profound non-autonomous functio...
Hoare, Matthew, Narita, Masashi
openaire +2 more sources
COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? [PDF]
, 2020 COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family.
Auwerx +30 more
core +2 more sources
RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins [PDF]
, 2018 RUNX gene over-expression inhibits growth of primary cells but transforms cells with tumor suppressor defects, consistent with reported associations with tumor progression.
Anderson, Gail +10 more
core +1 more source
Cytoplasmic chromatin triggers inflammation in senescence and cancer [PDF]
, 2017 Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a ...
Adams, Peter D. +23 more
core +2 more sources