Results 31 to 40 of about 29,788 (255)

RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis [PDF]

, 2016
Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. Here,
Algül, Hana, Demir, Ihsan Ekin, Diakopoulos, Kalliope Nina, Einwächter, Henrik, Heikenwälder, Mathias, Kehl, Timo, Korneeva, Olga, Lesina, Marina, Morton, Jennifer, Sansom, Owen J., Saur, Dieter, Schmid, Roland Michael, Sipos, Bence, Sperveslage, Jan, Steiner, Jörg Manfred, Wang, Timothy Cragin, Wimmer, Margit, Wörmann, Sonja Maria   +17 more
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SASP: Tumor Suppressor or Promoter? Yes! [PDF]

Trends in Cancer, 2016
Cellular senescence is a permanent growth arrest in cells with damage or stress that could lead to transformation. Some tumor cells also undergo senescence in response to chemotherapy. Senescent cells secrete cytokines and other factors of the senescence-associated secretory phenotype (SASP) that contribute to tumor suppression by enforcing arrest and ...
Sonia G, Rao, James G, Jackson
openaire   +2 more sources

Cancer cell cannibalism and the SASP: Ripples in the murky waters of tumor dormancy

Molecular & Cellular Oncology, 2017
Relapse in cancer patients following an apparent cure and a prolonged latency period, known as tumor dormancy, remains an unrelenting clinical crisis.
Thomas J. Bartosh
doaj   +1 more source

Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress

Molecular & Cellular Oncology, 2020
We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells.
Roberto Giambruno, Tiziana Bonaldi
doaj   +1 more source

Ex-SASP-erating cancer [PDF]

Science-Business eXchange, 2013
German researchers have identified a hypermetabolic phenotype in senescent tumor cells that exerts tumorigenic effects on other cells in the tumor microenvironment. Although small molecule inhibitors of the phenotype improved survival in a mouse model of lymphoma, future studies will need to determine whether the phenotype occurs in primary tumors.
openaire   +1 more source

Whole Chromosome Instability induces senescence and promotes SASP [PDF]

Scientific Reports, 2016
Abstract Age-related accumulation of ploidy changes is associated with decreased expression of genes controlling chromosome segregation and cohesin functions. To determine the consequences of whole chromosome instability ( W-CIN ) we down-regulated the spindle assembly ...
Andriani Grasiella Angelina, Almeida Vinnycius Pereira, Faggioli Francesca, Mauro Maurizio, Tsai Wanxia Li, Santambrogio Laura, Maslov Alexander, Gadina Massimo, Campisi Judith, Vijg Jan, Montagna Cristina   +10 more
openaire   +5 more sources

Teacher fabrication as an impediment to professional learning and development: the external mentor antidote [PDF]

, 2013
This paper reports findings from a study of the work of 'external mentors' associated with three programmes of support for the professional learning and development (PLD) of secondary science teachers in England.
Andrew J. Hobson, BERA, BERA, Bolam R., Bryk A. S., Bubb S., Cordingley P., CUREE (Centre for the Use of Research and Evidence in Education), Day C., Day C., Department for Education, Department for Education, Feiman-Nemser S., Goffman E., Hammersley M., Hargreaves A., Hargreaves D. H., Hobson A. J., Hobson A. J., Hobson A. J., Jenkinson K., Joanna McIntyre, Leaton Gray S., Lingard B., Lyotard J. F., Malderez A., McNally J., Moor H., Osborne J., Schlenker B. R., Sharp C., Shepherd C., Sullivan H. S., Tashakkori A., Yusko B.   +34 more
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Biliary Epithelial Senescence in Liver Disease: There Will Be SASP [PDF]

Frontiers in Molecular Biosciences, 2021
Cellular senescence is a pathophysiological phenomenon in which proliferative cells enter cell cycle arrest following DNA damage and other stress signals. Natural, permanent DNA damage can occur after repetitive cell division; however, acute stress or other injuries can push cells into premature senescence and eventually a senescence-associated ...
Vik Meadows, Leonardo Baiocchi, Debjyoti Kundu, Keisaku Sato, Yessenia Fuentes, Chaodong Wu, Sanjukta Chakraborty, Shannon Glaser, Gianfranco Alpini, Gianfranco Alpini, Lindsey Kennedy, Lindsey Kennedy, Heather Francis, Heather Francis   +13 more
openaire   +4 more sources

Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence. [PDF]

, 2018
To determine the role for mutations of MECP2 in Rett syndrome, we generated isogenic lines of human induced pluripotent stem cells, neural progenitor cells, and neurons from patient fibroblasts with and without MECP2 expression in an attempt to ...
Allen, Denise, Chronis, Contantinos, Cinkornpumin, Jessica, Fu, Kai, Germanguz, Igal, Korsakova, Elena, Kuoy, Edward, Langerman, Justin, Lee, Peiyee, Lowry, William E, Ohashi, Minori, Park, Jenny C, Pellegrini, Matteo, Plath, Kathrin, Salas, Carlos, Tran, Stephen, Vargas, Benni S, Xiao, Xinshu   +17 more
core   +2 more sources

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]

, 2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A., Giallongo S., Li Volti G., Lo Re O., Mazza T., Rappa F., Roskams T., Sanna P., Tsochatzis E., Van Haele M., Vinciguerra M., Vinh Luong T.   +11 more
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